Management of Pregnancy with Congenital Antithrombin III Deficiency: Two Case Reports and a Review of the Literature

Yamada, Takahiro; Yamada, Hideto; Morikawa, Mamoru; Kato, Emi H.; Kishida, Tatsuro; Ohnaka, Yoshito; Nikaido, Hiroki; Ozawa, Tetsuo; Fujimoto, Seiichiro

doi:10.1111/j.1447-0756.2001.tb01250.x

Cited by 27 publications

(37 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…43 Women with antithrombin deficiency are prone to pregnancy-associated venous thromboembolism. 44 Severe deficiencies in protein C and protein S result in purpura fulminans, venous thrombosis, and/or pulmonary embolism in the newborn. To date, there are no reports of humans deficient in TFPI.…”

Section: Role Of the Different Anticoagulant Pathways In Tissue-specimentioning

confidence: 99%

Tissue-Specific Hemostasis in Mice

Mackman

2005

ATVB

116

View full text Add to dashboard Cite

Abstract-Blood coagulation is essential to maintain hemostasis in organisms with a vascular network. Formation of a fibrin-rich clot at a site of vessel injury is a highly complex process that is orchestrated by the coagulation protease cascade. This cascade is regulated by 3 major anticoagulant pathways. Removal of a clot is mediated by the fibrinolytic system. Defects in the regulation of clot formation lead to either hemorrhage or thrombosis. Tissue factor, the primary cellular initiator of blood coagulation, is a transmembrane receptor that is expressed in a tissue-specific manner. The 3 major anticoagulants are tissue factor pathway inhibitor, antithrombin, and protein C, the latter requiring a transmembrane receptor called thrombomodulin for its activation. Tissue factor pathway inhibitor and thrombomodulin are expressed by endothelial cells in a tissue-specific manner, whereas antithrombin and protein C circulate in the plasma. Fibrinolysis requires the activation of plasminogen to plasmin, which is mediated by tissue-type plasminogen activator and urokinase-type plasminogen activator. Interestingly, tissue-type plasminogen activator is expressed by a subset of endothelial cells of discrete size and location.

show abstract

Section: Role Of the Different Anticoagulant Pathways In Tissue-specimentioning

confidence: 99%

Tissue-Specific Hemostasis in Mice

Mackman

2005

ATVB

116

View full text Add to dashboard Cite

show abstract

“…Samson et al 14 gave AT concentrate for the preparation of the delivery and shortly after delivery, while DeStefano et al 15 gave only one dose of AT concentrate after delivery. Yamada et al 16 showed a case of two pregnant women: a 35-year old pregnant patient was given only AT concentrate during pregnancy, while a 22-year old pregnant patient was given only LMWH in prophylactic doses and low doses of aspirin.…”

Section: Discussionmentioning

confidence: 98%

A successful outcome of pregnancy in a patient with congenital antithrombin deficiency

Mirjana¹,

Miković²,

Rakićević

et al. 2011

VOJNOSANIT PREGL

View full text Add to dashboard Cite

show abstract

“…This clinical case report suggests that the surgeon has to appreciate that ATIIID is a very rare phenomenon, especially in pregnant women after cardiac surgery, and correct management should be started as soon as possible to avoid a serious outcome. The first inherited case of ATD was diagnosed in 1965 as a thrombophilia state, but then no case of ATIIID was reported in postcardiac surgery in pregnant woman (15,16).…”

Section: Discussionmentioning

confidence: 99%