Management of Pregnancy in Sickle Cell Disease

Khare, M.; Bewley, Susan

doi:10.1002/9780470988398.ch12

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…Treatment approaches being explored in animal models include inhibition of selectin-mediated leukocyte adhesion with a recombinant preparation of the selectin ligand CD162 fused to the Fc fragment of immunoglobulin G [37]. It is a cytotoxic, mutagenic drug, however, and concerns about teratogenicity and unknown long-term toxicities dampen enthusiasm for its use, especially during pregnancy when SCD is exacerbated [38]. It is a cytotoxic, mutagenic drug, however, and concerns about teratogenicity and unknown long-term toxicities dampen enthusiasm for its use, especially during pregnancy when SCD is exacerbated [38].…”

Section: Resultsmentioning

confidence: 99%

Leukocyte adhesion and the pathophysiology of sickle cell disease

Okpala

2006

Current Opinion in Hematology

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Section: Resultsmentioning

confidence: 99%

Leukocyte adhesion and the pathophysiology of sickle cell disease

Okpala

2006

Current Opinion in Hematology

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“…Spontaneous miscarriage is another unfortunate outcome that occurs frequently. 25,26 Therefore, the pregnancy of patients with SCD should be handled delicately by medical care providers. Information on dehydration, cold, hypoxia, and their relation to SCD should be explained properly to the women who are planning to conceive.…”

Section: Management Of Sickle Cell Disease In Pregnancymentioning

confidence: 99%

Pregnancy-Related Thromboembolismin Sickle Cell Disease

AlDallal

2020

EMJ Hematol

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Haematological disorders are predominant in the tropical and subtropical countries where major problems of sickle-cell disease (SCD) and thalassaemias are often recorded. However, reports of these conditions have increased in the Western hemisphere more recently. Genetic counselling, early detection of the disease condition, and determining an appropriate treatment regimen remains the solution. Most molecular types of SCD have been determined and the pathological impact of individual types along with the degree of severity is known to clinical investigators and physicians. There is, however, a significant need for a proper counselling system for the clinical diagnosis in most countries. Lack of funding, trained personnel, relevant physicians, instruments, and laboratories are the challenges to overcome. Pregnancy-associated SCD and thromboembolism require special mention due to their mortality rate, complexity of treatment, and care necessities. This review considers some of the most important aspects of pregnancy-associated SCD and thromboembolism, shedding light on the present understanding of the disease condition, pathology, clinical issues, the association with venous thromboembolism, recent treatment measures, and clinical and social management of pregnant women and fetuses for patients with SCD. Integrated social and clinical care along with extensive timely medical and clinical counselling for patients can improve the present situation which is growing in different countries. To save future generations and pregnant mothers from the haematological disorders that could be either prevented or treated, essential genetic screening or counselling should be made a priority by governments. In addition, social education and campaigns related to the disease condition can help to improve the situation.

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Sickle Cell Disease

McMahon¹

2006

Pediatric Hematology

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Management of Pregnancy in Sickle Cell Disease

Cited by 4 publications

References 28 publications

Leukocyte adhesion and the pathophysiology of sickle cell disease

Leukocyte adhesion and the pathophysiology of sickle cell disease

Pregnancy-Related Thromboembolismin Sickle Cell Disease

Sickle Cell Disease

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