Management of pregnancy associated breast cancer with chemotherapy in a developing country

Sule, Emmanuel; Ewemade, Festus

doi:10.1016/j.ijscr.2015.10.008

Cited by 7 publications

(6 citation statements)

References 17 publications

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“…Some of such areas are: CT images, growth factor levels in incident breast cancer, hormone receptor status, cytokine circulation, secretagogue users in breast cancer treatments, chemokine levels, breast cancer and diabetes mellitus co-infection and treatment, breast cancer and HIV treatment, breast cancer and pregnancy. Others are: proteome analysis, risk factors analysis, breast examination, screening, management and breast cancer awareness, epidemiology, risk assessment tools, treatment options: radiotherapy treatment versus chemotherapy, survival analysis, breast cancer subtypes, biomarkers, socio-cultural barriers to treatment, socio-demographic factors and alternative medicine approach, genetic risk, dietary patterns, early diagnostics and treatment and others [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] .…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Breast cancer patients in Nigeria: Data exploration approach

2017

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Breast cancer is the type of cancer that develops from breast tissue; it is mostly common in women and it is one of the most studied diseases, largely because of its high mortality (second to lung cancer). However, it occurs in males also. This article presents a statistical study of the distribution of age, gender, length of stay, mode of diagnosis, status (dead or alive) after treatment and the location of breast cancer among 300 patients admitted in the University of Ilorin teaching hospital, Ilorin, Nigeria. The study covers a period of five (5) years; from 2011 to 2016 and logistic regression was used to perform the basic analysis in this study. It was discovered that the age of patients and the location of the breast cancer (right or left) contributes significantly to the survival of the patients. However, early detection and treatment of the disease is highly encouraged. This study also recommends that awareness should be taken to the grassroots and males should not be excluded from this discussion.

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Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Breast cancer patients in Nigeria: Data exploration approach

2017

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“…While the description of said treatment was not identified, this study did validate that therapeutic abortion or termination of pregnancy was not necessary for all patients prior to initiating cancer treatment [8]. Not only is termination not necessary, but some studies have also demonstrated a lack of survival benefit to the patient with termination of pregnancy prior to initiation of cancer treatment [1][2][3][4]7].…”

Section: Discussionmentioning

confidence: 75%

“…Adriamycin and cyclophosphamide are generally well tolerated in pregnancy and suggested to be two of the chemotherapy drugs of choice for treatment of PABC in a recent expert opinion published by Lambertini, et al in which he reviews the literature to date which is admittedly limited of the safety profile of these drugs during pregnancy. The most common medical side effect of these drugs is myelosuppression in both the mother and fetus [3,5,7,9,12,13]. In one study, Rouzier demonstrated the chemosensitivity to these drugs was the same in tumors of PABC and tumors of non-pregnancy associated breast cancers [3,14].…”

Section: Discussionmentioning

confidence: 99%

“…Despite its rarity, clinicians must have a high index of suspicion for malignancy. A breast mass that is persistent for greater than 2 weeks should be further evaluated with imaging [1,7]. Any palpable breast mass that shows atypical or suspicious features either clinically or on imaging, must undergo cytological and histological evaluation with a core biopsy [1,6].…”

Section: Introductionmentioning

confidence: 99%

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Importance of a Multidisciplinary Approach to Breast Cancer Treatment in Pregnancy: Case Report of New Diagnosis of Pregnancy-Associated Breast Cancer

Grant¹,

DiCarlo²,

Woessner-Hoyson³

2016

J Carcinog Mutagen

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Pregnancy-Associated Breast Cancer (PABC) is a rare diagnosis and includes new diagnoses of cancer both during pregnancy as well as within the first year post-delivery. Due to its rarity, there is of yet no gold standard treatment nor is there a standardized regimen of treatment during pregnancy according to the American College of Obstetrics and Gynecology (ACOG). We report a case involving a 35-year-old gravida 2 para 1-0-0-1 who was diagnosed with clinical stage II (T2 N1) breast cancer in the early third trimester of pregnancy after physical examination revealed a palpable mass. Ultrasound-guided biopsy revealed poorly differentiated infiltrating ductal carcinoma, nuclear grade 3, with micropapillary features, estrogen receptor (ER 90%), progesterone receptor (PR 25%) positive, HER2 positive 3+ with Ki67 index 75%. After extensive counseling and discussion between Obstetrics, Maternal Fetal Medicine, Breast Surgery, Neonatal ICU, and Oncology, a decision was made to initiate neoadjuvant chemotherapy (NAC) with adriamycin and cyclophosphamide. Our patient completed 4 total NAC treatments prior to delivery followed by a regimen of weekly taxol plus herceptin and perjeta postpartum. This patient strongly desired to carry the pregnancy to term and began treatment prior to delivery, making this case unique in comparison to other publications in which treatment was delayed until after delivery, or the pregnancy was terminated prior to beginning treatment. Our case highlights the importance of a multi-disciplinary approach to counseling patients in this unique situation to allow them the autonomy to choose the treatment best for them and their baby.

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“…Other protocols have been reported to produce different fetal growth outcomes. Sule and Ewemade reported that doxorubicin and cyclophosphamide administration for breast cancer treatment during the second trimester in a developing country did not affect birth weight [ 39 ]. Furthermore, Ring et al retrospectively described the outcomes of 28 pregnant patients treated with chemotherapy for breast cancer at 5 hospitals in London.…”

Section: Chemotherapy For Breast Cancer During Pregnancymentioning

confidence: 99%

Does Chemotherapy for Gynecological Malignancies during Pregnancy Cause Fetal Growth Restriction?

Abdalla

Bizoń

Piórkowski

et al. 2017

BioMed Research International

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Cancer and pregnancy rarely coincide. Gynecological cancers are among the most common malignancies to occur during pregnancy, and chemotherapy with or without surgery is the primary treatment option. The main concern of administering chemotherapy during pregnancy is congenital malformation, although it can be avoided by delaying treatment until after organogenesis. The dose, frequency, choice of chemotherapeutic agents, time of treatment commencement, and method of administration can be adjusted to obtain the best maternal treatment outcomes while simultaneously minimizing fetal toxicity. Use of chemotherapy after the first trimester, while seemingly safe, can cause fetal growth restriction. However, the exact effect of chemotherapy on such fetal growth restriction has not been fully established; information is scarce owing to the rarity of malignancy occurring during pregnancy, the lack of uniform treatment protocols, different terminologies for defining certain fetal growth abnormalities, the influence of mothers' preferred options, and ethical issues. Herein, we present up-to-date findings from the literature regarding the impact of chemotherapy on fetal growth.

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Management of pregnancy associated breast cancer with chemotherapy in a developing country

Cited by 7 publications

References 17 publications

Breast cancer patients in Nigeria: Data exploration approach

Breast cancer patients in Nigeria: Data exploration approach

Importance of a Multidisciplinary Approach to Breast Cancer Treatment in Pregnancy: Case Report of New Diagnosis of Pregnancy-Associated Breast Cancer

Does Chemotherapy for Gynecological Malignancies during Pregnancy Cause Fetal Growth Restriction?

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