2013
DOI: 10.3109/00016489.2013.793821
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Management of post-traumatic cerebrospinal fluid (CSF) leak of anterior skull base: 10 years experience

Abstract: The overall risk of reccurence was 22.5%. Recurrence was represented by the presence of CSF rhinorrhea in 12.5% and the appearance of meningitis in 10% of patients. The overall risk of postoperative anosmia was 27.5%. A wait and see policy led to a higher risk of developing meningitis than surgical repair (p = 0.0003). The absence of pretherapeutic topographical diagnosis led to a higher risk of recurrence of CSF rhinorrhea (p = 0.01). The endonasal approach resulted in less postoperative anosmia (p = 0.006).

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Cited by 39 publications
(62 citation statements)
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“…We think that a wait and see policy can also be acceptable in selected cases, when beta2 transferrin sampling is negative or when the leaking fluid is difficult to collect [28]. Such conservative management can lead to the complete resolution of symptoms, but it is burdened by a high risk of intracranial infections and recurrences [28].…”
Section: Discussionmentioning
confidence: 97%
See 1 more Smart Citation
“…We think that a wait and see policy can also be acceptable in selected cases, when beta2 transferrin sampling is negative or when the leaking fluid is difficult to collect [28]. Such conservative management can lead to the complete resolution of symptoms, but it is burdened by a high risk of intracranial infections and recurrences [28].…”
Section: Discussionmentioning
confidence: 97%
“…We think that a wait and see policy can also be acceptable in selected cases, when beta2 transferrin sampling is negative or when the leaking fluid is difficult to collect [28]. Such conservative management can lead to the complete resolution of symptoms, but it is burdened by a high risk of intracranial infections and recurrences [28]. Indeed, Yadav and colleagues [29] reported a 10% rate of intracranial infection in patients with untreated rhinoliquorrhea within a year, and a 85% infection rate within 10 years [29,30].…”
Section: Discussionmentioning
confidence: 98%
“…Schoentgen C et al reports a 22.5% failure rate [19] and Virk JS et al reports an 11% failure rate . [20] American college recommends that the success rate of endoscopic repair should be above 90%.…”
Section: Discussionmentioning
confidence: 99%
“…15 A recent 10-year study published in 2013 also corroborates this view. 16 It is therefore safe to opine that anterior CSF leaks that do not respond to conservative management are probably best managed by endoscopic repair in the first attempt as they score over conventional approaches, the relative advantages and disadvantages of which have already been mentioned above.…”
Section: Resultsmentioning
confidence: 99%