Management of pollen food and oral allergy syndrome by health care professionals in the United Kingdom

Making the Most of In Vitro Tests to Diagnose Food Allergy

“…For example, patients with raised Ara h 2 sIgE do not necessarily have severe PA and can actually pass a peanut OFC 122 ; 10% of patients with PFAS can have systemic reactions and 1% to 2% experience anaphylaxis 123, 124. The risk assessment of allergic patients depends on factors other than mere individual players of IgE-mediated food-induced allergic reactions (such as single allergens or epitopes, IgE, or basophils) and requires a holistic clinical evaluation of the patient.…”

Profiles of Birch Sensitization (Bet v 1, Bet v 2, and Bet v 4) and Oral Allergy Syndrome Across Italy

“…However, the management of OAS remains controversial, mainly with respect to the role of molecular diagnosis [27]. In this regard, sensitization to Bet v 1 has been shown to be frequently associated with OAS in patients with pollen allergy [28]. In addition, application of microarray for measurement of PR-10 proteins was a reliable approach in the diagnosis of apple-induced OAS in patients with birch pollen allergy [29].…”

Reaction phenotypes in IgE-mediated food allergy and anaphylaxis

“…4 It is not clear why some patients experience more significant symptoms and whether this is due to polysensitization to more stable allergens, such as lipid transfer proteins 5 or diagnostic misclassification. 6,7 Component resolved diagnostics have improved our ability to discriminate between PFAS and primary food allergy but are only of limited use in identifying patients with PFAS at risk of severe systemic reactions. 8,9 Whether prescription of epinephrine autoinjector devices is indicated in patients with PFAS remains unclear.…”

“…8,9 Whether prescription of epinephrine autoinjector devices is indicated in patients with PFAS remains unclear. 4,6,7 Is Food-Induced Anaphylaxis: Pathophysiologically Different Than Nonfood Anaphylaxis?…”