Management of patients with pulmonary mycobacteriosis in France: a multicenter retrospective cohort study

Bémer, Pascale; Peuchant, Olivia; Guet-Revillet, Hélène; Bador, Julien; Balavoine, C.; Basille, Damien; Beltramo, Guillaume; Blanc, F.–X.; Blanchard, Élodie; Boulanger, Sarah; Bourgoin, A.; Boutoille, David; Cambau, Emmanuelle; Canis, F.; Caparros, Didier; Carricajo, Anne; Carrière, Christian; Couetdic, G.; Couturaud, Francis; Dalphin, Jean‐Charles; Degot, T.; Desquiens, Marion; Devouassoux, Gilles; Duez, Jean-Marie; Dumitrescu, Oana; Dupuy-Grasset, Magali; Gaudart, Alice; Georges, Marjolaine; Godet, C.; Godreuil, Sylvain; Guillouzouic, A.; Hamdad-Daoudi, Farida; Héry-Arnaud, Geneviève; Koebel, Christelle; Lagrange, A.; Lanotte, Philippe; Marchand-Adam, S.; Mougari, Faïza; Murris, Marlène; Patry, Isabelle; Montclos, Michèle Pérouse de; Raskine, Laurent; Risso, Karine; Segonds, Christine; Sicard, D; Terru, Dominique; Vachée, Anne; Vergnon, Jean‐Michel; Martin, C.; Schramm, Frédéric; Andréjak, Claire

doi:10.1186/s12890-021-01701-5

Cited by 6 publications

(2 citation statements)

References 29 publications

(39 reference statements)

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“…Generally, MAC is the most common species of NTM-LD, followed by MABC, and both are commonly studied. However, more isolates of M. xenopi have been found in Europe than in the United States and East Asia ( Bemer et al, 2021 ). In Taiwan, MK-LD is ranked only as the third most common NTM-LD ( Lee et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

The Impact of Nontuberculous Mycobacteria Species on Mortality in Patients With Nontuberculous Mycobacterial Lung Disease

et al. 2022

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Patients with nontuberculous mycobacterial lung disease (NTM-LD) have increased mortality. The impact of NTM species on the risk of mortality remains unclear, especially that of death by non-cancer causes. We conducted a retrospective cohort study from 2006 to 2018 in a tertiary-care hospital in Taiwan. We enrolled patients who fulfilled the microbiological diagnostic criteria of NTM-LD. The mortality causes within 8 years after diagnosis were identified, and the Cox proportional hazard regression was performed for risk factors of mortality. A total of 1,652 subjects with NTM-LD were included. Among them, 723 (43.8%) were infected by Mycobacterium avium complex (MAC), 408 (24.7%) by M. abscessus complex (MABC), 120 (7.3%) by Mycobacterium kansasii (MK), 304 (18.4%) by other rapid-growing mycobacteria (RGM), and 97 (5.9%) by other slow-growing mycobacteria (SGM) groups. The 8-year all-cause mortality was 45.2% for all and the highest in the MK-LD group (59.2%), followed by the MABC-LD and MAC-LD groups. The adjusted hazard ratios were 2.20 (95% confidence interval: 1.40–3.46) in the MK-LD, 1.85 (1.54–2.22) in the MABC-LD, and 1.65 (1.12–2.41) in the MAC-LD groups for all-cause mortality, compared with the SGM group. Kaplan–Meier survival curves showed that all-cause mortality, non-cancer mortality, and mortality due to chronic airway diseases were significantly correlated with NTM species (log-rank p = 0.0031, < 0.001, and 0.001, respectively). High 8-year mortality rates were found in patients with NTM-LDs according to different NTM species. Notably, the difference was significant in non-cancer mortality causes, especially in chronic airway diseases.

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Section: Discussionmentioning

confidence: 99%

The Impact of Nontuberculous Mycobacteria Species on Mortality in Patients With Nontuberculous Mycobacterial Lung Disease

et al. 2022

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“…M. a. infections represent emerging infections in patients with CF or other chronic respiratory diseases [ 16 ]. At present, M. a. is usually identified only at the species level in routine laboratory practice [ 9 , 34 ]. In our laboratory, we introduced PCR methods for the subspecies level identification.…”

Section: Discussionmentioning

confidence: 99%

Mycobacterioses Induced by Mycobacterium abscessus: Case Studies Indicating the Importance of Molecular Analysis for the Identification of Antibiotic Resistance

et al. 2022

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Mycobacterioses are less frequently occurring but serious diseases. In recent years, at a global level, the incidence of mycobacterioses induced by the rapidly growing species Mycobacterium abscessus (M. a.), which is considered to be the most resistant to antibiotics and most difficult to treat, has been on the rise. Correct identification to the level of the subspecies (M. a. abscessus, M. a. massiliense, and M. a. bolletii) and determination of its sensitivity to macrolides, which are the basis of combination therapy, are of principal importance for the management of the disease. We describe five cases of mycobacterioses caused by M. a., where the sequencing of select genes was performed to identify the individual subspecies and antibiotic resistance. The analysis of the rpoB gene showed two isolates each of M. a. abscessus and M. a. massiliense and one isolate of M. a. bolletii. The complete (full length) erm(41) gene responsible for the development of inducible resistance to macrolides was demonstrated in both M. a. abscessus and M. a. bolletii isolates. A partially deleted and non-functional erm(41) gene was demonstrated in M. a. massiliense isolates. The subsequent sequencing of the full length erm(41) gene products showed, however, the mutation (T28→C) in both isolates of M. a. abscessus, causing a loss of the function and preserved sensitivity to macrolides. The antibiotic sensitivity testing confirmed that both the isolates of M. a. abscessus and M. a. massiliense were sensitive to clarithromycin even after prolonged 14-day incubation. The inducible resistance to clarithromycin was maintained only in M. a. bolletii. Thus, the sequence analysis of the erm(41) gene can reliably identify the preservation of sensitivity to macrolides and serve as an important tool in the establishment of therapeutic regimens in cases of infections with M. abscessus.

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Global Epidemiology of Nontuberculous Mycobacterial Pulmonary Disease

Prevots,

Marshall,

Wagner

et al. 2023

Clinics in Chest Medicine

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Management of patients with pulmonary mycobacteriosis in France: a multicenter retrospective cohort study

Cited by 6 publications

References 29 publications

The Impact of Nontuberculous Mycobacteria Species on Mortality in Patients With Nontuberculous Mycobacterial Lung Disease

The Impact of Nontuberculous Mycobacteria Species on Mortality in Patients With Nontuberculous Mycobacterial Lung Disease

Mycobacterioses Induced by Mycobacterium abscessus: Case Studies Indicating the Importance of Molecular Analysis for the Identification of Antibiotic Resistance

Global Epidemiology of Nontuberculous Mycobacterial Pulmonary Disease

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