Management of patients with a persistently elevated PSA after radical prostatectomy: a narrative review

Editorial: Post Operative Radiation Treatment for Prostate Cancer

“…Approximately 30% of patients treated with RP for prostate cancers will experience biochemical recurrence (BCR) (1). Post-operative radiation therapy (RT) can be either offered immediately after the surgery in case of aggressive pathological featuresdefined adjuvant treatment or be proposed for patients experiencing BCR as an earlysalvage strategy (2)(3)(4)(5). Thereby the management of the postoperative BCR is most often based on salvage radiotherapy (SRT) with or without the addition of hormone therapy (HT) (3)(4)(5).…”

“…Post-operative radiation therapy (RT) can be either offered immediately after the surgery in case of aggressive pathological featuresdefined adjuvant treatment or be proposed for patients experiencing BCR as an earlysalvage strategy (2)(3)(4)(5). Thereby the management of the postoperative BCR is most often based on salvage radiotherapy (SRT) with or without the addition of hormone therapy (HT) (3)(4)(5). The indications for SRT +/-HT are established in the setting of a rising PSA level, after a period where an undetectable PSA was achieved (2,3).…”

“…The indications for SRT +/- HT are established in the setting of a rising PSA level, after a period where an undetectable PSA was achieved ( 2 , 3 ). However, immediate SRT in case of detectable PSA immediately after RP, but also SRT when a macroscopic recurrence in the prostate bed is shown by functional images, are two issues which treatment options and prognosis are still unclear ( 4 , 5 ). The present edition of Frontiers in Oncology focuses on the need to improve the outcome of men with high risk or recurrent prostate cancer.…”