Management of pain after abdominal surgery: dipyrone compared with pethidine.

Patel, Chandrashekhar V.; Koppikar, M. G.; Patel, M. S.; Gb, Parulkar; Pereira, Pinto

doi:10.1111/j.1365-2125.1980.tb01822.x

Cited by 32 publications

(12 citation statements)

References 7 publications

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“…9 A variety of clinical studies have shown that dipyrone is effective in the treatment of acute painful conditions, including surgical pain. [10][11][12][13][14][15][16][17][18] Tramadol is an analgesic drug whose mechanism of action is unusual in that one optical isomer exerts typical opioid-type effects and the other isomer interacts with the reuptake and/or release of norepinephrine and serotonin in nerve terminals. 19 Tramadol infusion, in addition to on-demand intravenous (IV) tramadol boluses, has been used and recommended for intravenous analgesia in patients recovering from major gynecological operations.…”

mentioning

confidence: 99%

Efficacy and safety of dipyrone versus tramadol in the management of pain after hysterectomy: A randomized, double-blind, multicenter study

Torres

Rodriguez²,

Montero³

et al. 2001

Regional Anesthesia and Pain Medicine

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mentioning

confidence: 99%

Efficacy and safety of dipyrone versus tramadol in the management of pain after hysterectomy: A randomized, double-blind, multicenter study

Torres

Rodriguez²,

Montero³

et al. 2001

Regional Anesthesia and Pain Medicine

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“…onset of pain relief was rapid within 30 min -and was maintained for 6 h. At the doses used, analgesia with metamizole was similar in terms of onset, degree and duration to that of pethidine. no side-effects were attributed to either drug in this study (72).…”

Section: Comparative Efficacy/evaluation With Other Therapiesmentioning

confidence: 83%

Metamizole: A Review Profile of a Well-Known “Forgotten” Drug. Part II: Clinical Profile

Nikolova

Petkova

Tencheva

et al. 2013

Biotechnology & Biotechnological Equipment

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“…Comparable studies on metamizole sodium and paracetamol administered at the same doses revealed a stronger analgesic effect and an earlier increase of pain threshold (an earlier beginning of action) when metamizole sodium was applied (12,13). When administered parenterally at a dose of 2.0-2.5 g, metamizole sodium caused a 60% decrease in pain intensity achieved in 1 hour and its analgesic effect, which persists for 4-6 hours, is as strong as 50 mg intramuscular pethidine (14)(15)(16)(17). In one of randomized studies comparing efficacy of metamizole sodium and morphine in managing pain during first 24 postoperative hours a similar effect was achieved with 8 g metamizole sodium and 40 g morphine (17).…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Analgesic Effect of Metamizole Sodium in Patients Operated on for Goitre

Srebrzyński

Ziółkowski

Płużańska

et al. 2008

Polish Journal of Surgery

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The aim of the study was to evaluate the analgesic effect of metamizole sodium administered intravenously during the day after surgery in patients operated on for nodular goitre -using the 11-point NAS scale (Numeric Analog Scale). Material and methods. The study was comprised of 114 patients who had undergone surgery for nontoxic: 84 (73.7%) or toxic: 30 (26.3%) nodular goitre. The goitre size, according to the WHO classification ranged between III and I° (2). I° goitre was found in 31 (27%) patients, II° goitre -in 46 (40.4%) patients and III° goitre -in 37 (32.4%) patients. The age of patients ranged between 22 and 75 years (median 53, IQR 43-61). The goitre was localized in the neck in 103 (90.4%) patients and it partially reached the superior aperture of the thorax with its lower poles in 11 (9.6%) patients. Patients with coexisting diseases such as diabetes mellitus or peripheral neuropathy were excluded from the study. Patients were randomly assigned to 4 groups. Group I included 38 subjects in whom metamizole sodium was applied at a dose of 1 g intravenously every 6 hours for a day after surgery; the first dose was administered at the moment of surgical wound closure. Group II included 37 patients in whom metamizole sodium was applied according to the above-mentioned regimen and, additionally the surgical wound was injected with 10 ml of bupivacaine 0.25%. Group III consisted of 36 patients in whom 1 g of metamizole was first administered intravenously thirty minutes before surgery and the subsequent doses were systematically repeated at time intervals of 6 hours (preemptive analgesia), avoiding buvacaine wound infiltration. Group IV included 40 patients in whom ketoprophen was administered intravenously at a dose of 0.1 g every 6 hours for a day after the procedure. Surgical wounds were not injected with buvacaine in these patients, similarly as in groups III and I. In case of severe pain patients could additionally receive morphine 1 mg on-demand. Results. Pain intensity was analyzed every 6 hours on NAS scale and pain scores ranged from 1 to 5.5. At all time points, the highest pain intensity scores were found in patients who received metamizole as monotherapy (group I) or ketoprofen (group IV), while the lowest were found in the groups where surgical wound was additionally injected with bupivacaine solution (group II) or additional metamizole dose was used before the procedure (group III). Patients from group II rated their pain intensity as slightly higher or similar to that in group III (statistically insiginficant). Similarly patients from group I had pain scores slightly higher or similar to scores reported in group IV (statistically insiginficant). Conclusions. 1. The most intense pain was observed during the first 12 hours after thyroid surgery. 2. Administration of metamizole sodium according to the regimen that was applied in groups II and III provided sufficient analgesia. 3. Infiltration of the surgical wound with buvacaine or administration of an additional dose of metamizole sodium prior ...

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Management of pain after abdominal surgery: dipyrone compared with pethidine.

Cited by 32 publications

References 7 publications

Efficacy and safety of dipyrone versus tramadol in the management of pain after hysterectomy: A randomized, double-blind, multicenter study

Efficacy and safety of dipyrone versus tramadol in the management of pain after hysterectomy: A randomized, double-blind, multicenter study

Metamizole: A Review Profile of a Well-Known “Forgotten” Drug. Part II: Clinical Profile

Analysis of the Analgesic Effect of Metamizole Sodium in Patients Operated on for Goitre

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