Management of osteoporosis and associated quality of life in post menopausal women

Cortet, Bernard; Blotman, F; Debiais, Françoise; Huas, Dominique; Mercier, Florence; Rousseaux, Chantal; Berger, Véronique; Gaudin, Anne-Françoise; Cotté, François-Emery

doi:10.1186/1471-2474-12-7

Cited by 26 publications

(19 citation statements)

References 18 publications

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“…At present there is no 'consensus conference' about the management of osteoporotic vertebral fractures (OVF) (1,2). The duration and indications for proceeding beyond conservative treatment of OVF remain unclear, and the surgical criteria are not distinctly defined.…”

Section: Introductionmentioning

confidence: 99%

“…In the past, a conservative treatment for at least one month was deemed inappropriate for the majority of the vertebral fractures. However, when pain persisted after conservative treatment, it was necessary to consider surgical solutions including: vertebroplasty for vertebral fractures with height loss less than 30% and kyphoplasty for height loss greater than 30% (1,2). Currently, a treatment of this type is not feasible because it results in a poor quality of life, does not stop the domino effect and is associated with poor results.…”

Section: Introductionmentioning

confidence: 99%

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Third-generation percutaneous vertebral augmentation systems

Vanni¹,

Galzio²,

Казакова³

et al. 2016

J. Spine Surg.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Third-generation percutaneous vertebral augmentation systems

Vanni¹,

Galzio²,

Казакова³

et al. 2016

J. Spine Surg.

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“…This could have impacted physician's prescribing pattern. 10,11 In our study, the mean age group of presenting patients was 56.2±6.6 years. The mean duration since menopause among these patients was 8.2±5.1 years.…”

Section: Discussionmentioning

confidence: 55%

Evaluation of prescription pattern and quality of life in postmenopausal osteoporosis: a cross sectional study

Agrawal¹,

Patel²,

Malhotra³

et al. 2019

Int J Basic Clin Pharmacol

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Background: Osteoporosis (OP) is a silently progressing metabolic bone disease that results in loss of mineralized bone and subsequent fractures with minor trauma. Fracture related pain and physical inability to perform activities of daily living can lead to psychological consequences that impair Quality of Life (QoF). However, much less is known about Indian scenario. Hence, our study becomes imperative. Aim of this study to the drug utilization pattern and to analyze Quality of life of postmenopausal women suffering from osteoporosis.Methods: An analytical cross-sectional study was done on 91 post-menopausal osteoporotic women. Drug utilization pattern was evaluated. Pre-validated QUALEFFO-31 questionnaire was administered to each patient to record patient’s perceived QoL. Scores were calculated according to the algorithm. Higher scores indicated poor QoL. The collected data was analyzed with SPSS software (version 23)and p value ≤0.05 was considered as statistically significant.Results: The mean age group of presenting patients was 56.2±6.6 years. All the patients received Calcium and vitamin D supplements and non-steroidal anti-inflammatory drugs for pain relief. But only 33% of the patients received any one of the bisphosphonates (BP). For analysis, patients were grouped into Group-1(n=60) who did not and Group-2 (n=31) who did receive a BP. QOL analysis showed that pain domain was affected the most. Also, patients in Group 2 reported worse score in all the domains in comparison to Group 1 (P<0.05). It is likely that BP might need more time to show considerable effect or because it was added only to those patients who already had more complaints and could afford the high cost.Conclusion: BP in spite of being the drug of choice for OP is used less commonly in India. OP causes pain and physical debilitation with detrimental effect on mental health. Longer duration prospective studies are needed to study the association of QoL and use of BP in OP patients.

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“…Therefore, the incidence of fracture is higher in women than in men. 14 Estrogen plays an important part in maintaining bone strength because it helps keep bone remodeling rates low. There are two lines of cells for bone remodeling, the bone-eating cells (osteoclasts) and the bone-forming cells (osteoblasts).…”

Section: Discussionmentioning

confidence: 99%

The perioperative enhancing factors that might help the postmenopausal women tolerate the spinal implants

Awadalla¹,

Assar

Mustafa³

et al. 2014

Egyptian Spine Journal

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Background Data: Osteoporosis is a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration, with a consequent increase in bone fragility. Moreover, it is a condition that is both preventable and treatable if caught in time. Purpose: Evaluation the different perioperative enhancing factors available that might increase spinal fixation success rate in low bone density postmenopausal women. Study Design: retrospective analysis of a case series. Patients and Methods: Between May 2011 and May 2013, twenty four low bone density post-menopausal women were included in this retrospective study. All of them were admitted at KSMH-Hospital-Tabouk. During that period, they had either thoracic or lumbar implants for two major indications, osteoporotic vertebral compression fractures and osteodegenerative spondylolisthesis. Different techniques and precautions were followed to maximize the outcome. Pre-and postoperative bone densitometry, radiograph, pain and functional outcome assessment were documented. All patients were followed up for at least 12 months. Results: The mean age of the ladies was fifty eight years. 62.5% of the patients were classified as osteoporotic, with a further 37.5%, being osteopenia. Ten surgical fractures and fourteen cases of spondylolisthesis had implants. In densitometry, little postoperative change happened in the fracture series. However, Remarkable improvement was obvious in the spondylolisthesis series. Based on postoperative radiograph control and follow up, no reported cases of implant failures, loosening, pull-out screws or pseudoarthrosis necessitated re-surgery in one hundred twenty inserted screws. Three cases of severely osteoporotic spondylolisthesis were supported with rhBMP-2 that showed adequate fusion before expected. Out Egy Spine J -Volume 10 -April 2014 THE PERIOPERATIVE ENHANCING FACTORS THAT MIGHT HELP THE POSTM E N O PAUS A L WO M E N of twenty two cement injected screws in four spondylolisthesis cases, one screw showed silent extra vertebral leakage and failure of injection in another one. In the fracture series: The Beck's index mean pre-and postoperative was (0.44 versus 0.67, P=0.013). The kyphotic angle mean pre-and postoperative was (13 ∘ versus 8 ∘ , P=0.007). In the spondylolisthesis series: The total pre-and postoperative score of disc height narrowing was (77 versus73, P=0.95). No change in the osteophyte score pre-and postoperatively. Vacuum Sign was positive in 40% of fracture series and 57% of spondylolisthesis series. It did not show any change in the former. However, the latter showed an improvement in 37.5% cases completely and 25% partially. The lumbar lordosis angle mean pre-and postoperative was (25 ∘ versus 29 ∘ , P=0.01). 40% in the fracture series with marked paraparesis and 7% in the spondylolisthesis regained the full power by the end of the year. Pre-and postoperative mean of low back pain rating scale were (115 versus 23, P=0.001). pre-and postoperative mean of walking distance in meters were (22 versus 448, P=0.0...

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Management of osteoporosis and associated quality of life in post menopausal women

Cited by 26 publications

References 18 publications

Third-generation percutaneous vertebral augmentation systems

Third-generation percutaneous vertebral augmentation systems

Evaluation of prescription pattern and quality of life in postmenopausal osteoporosis: a cross sectional study

The perioperative enhancing factors that might help the postmenopausal women tolerate the spinal implants

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