Management of oral mucositis during local radiation and systemic chemotherapy: A study of 98 patients

Clinical application of Chamomilla recutita in phlebitis: dose response curve study

“…With regard to the clinical phase, research subjects in all groups were comparable, as the main confounding Other clinical trials have confirmed the antiinflammatory effect of C. recutita in radiation dermatitis, through the use of ointments with chamomile extract (Kamilosan ® ) (18) , in mucositis, through oral solution (Kamilosan ® Solução Oral) (19) , in contact dermatitis and eczema, through ethanolic extract (20)(21) , showing even superior efficacy results when compared with steroidal and non-steroidal anti-inflammatory drugs (21) .…”

Dietary Supplement Use in Cancer Care: Help or Harm

“…Utility of chamomile extract mouthwashes was supported in some but not all of the trials. In an uncontrolled case series, a heterogeneous group of chemotherapy and radiation therapy subjects, treated with a commercial chamomile extract (Kamillosan), were reported to develop less mucositis if treated prophylactically and to heal faster if treated after symptoms developed [129]. A case report of a patient with severe mucositis following a methotrexate overdose reported resolution after rinsing with chamomile tea instead of using conventional treatments [130].…”

“…Lower incidence of new disease, new metastases, or death; increased time to relapse [102,103] Probiotics in biliary cancer patients undergoing surgery; colorectal cancer patients undergoing chemotherapy; patients receiving abdominal and pelvic radiation Lower postoperative infection rates; decreased gastrointestinal toxicity (diarrhea) with less hospital care and less reduction in chemotherapy; decreased incidence of diarrhea [106,[143][144][145][146] Glutamine in variety of cancer patients undergoing chemotherapy and radiation Decreased rates and severity of mucositis, neuropathy, and intestinal toxicity; decreased use of pain medication in stomatitis patients; improved nutrition in stomatitis patients; improved ADL in neuropathy patients [112-119, 137-139, 148-150] Vitamin E topically in children undergoing bone marrow transplant; in adults undergoing chemotherapy or radiation to head and neck area Improved stomatitis [122,124,125] Zinc in head and neck patients during radiation therapy Improved stomatitis [126,127] (continued on next page) Chamomile extract as mouthwash in chemotherapy and radiation Improved stomatits sometimes [129,130] Homeopathic remedy including Arnica montana in chemotherapy Improved stomatitis [132] Proteolytic enzymes in head and neck patients with radiation…”

Toxicidad y tratamientos de soporte en oncología radioterápica: toxicidad en el área de O.R.L. Prevención y tratamiento

“…Para su prevención se recomienda una meticulosa valoración previa al tratamiento y correcta higiene bucodental 4 , aunque las soluciones que mezclan antibióticos y antifúngi-cos no han demostrado eficacia 5 ; los enjuagues con agua salina bicarbonatada alivian más que el agua oxigenada diluida que puede ser perjudicial 4 ; el agua de manzanilla parece ser útil en un estudio no controlado (6). El sulfato de zinc, agente cicatrizante que estimula el crecimiento del epitelio y neutraliza los radicales libres hidroxilo, a una dosis de 50 mgrs/8h consiguió reducir la severidad de la mucositis en un ensayo aleatorio y prospectivo 7 .…”