Management of Optic Disk Pit–associated Macular Detachment With Tisseel Fibrin Sealant

Sabti, Khalid Al; Kumar, Naveen; Chow, David R.; Kapusta, Michael A.

doi:10.1097/icb.0b013e3180eaa21b

Cited by 25 publications

(21 citation statements)

References 6 publications

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“…There are several reports suggested sealing of the optic disc pit during surgery prevents passage of fluid into the subretinal spaces. Techniques designed to seal the optic disc pit include injection of autologous platelets; covering optic disc pit with ILM inverted flap; tissue glue pit sealing; autologus sclera pit clotting [21,22]. In turn the results of fenestration of internal retina (partial thickness retinotomy) show complete resolution of foveal fluid in 94% of eyes; with significantly improved of visual acuity in 56% of cases [23].…”

Section: Discussionmentioning

confidence: 99%

Subretinal Tissue Glue Injection in Surgery of Macular Detachment Associated With Congenital Optic Disc Pit

Jurowski¹,

Górnik²

2016

J Clin Exp Ophthalmol

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Congenital optic disc pit is a rare finding that develops from incomplete closure of the embryonic choroid fissure. Maculopathy is a major cause of visual deterioration. The treatment of the macular detachments associated with congenital optic disc pits remains controversial however it is emphasized that rerouting fluid from subretinal space may be efficient method. Main drawback of commonly use surgical methods is slow reabsorption of fluid taking weeks or even months. We report a different surgical approach in 2 patients consisting of vitrectomy, subretinal tissue glue injection followed by gas tamponade that allowed achieving very fast functional and anatomic recovery within 1 month.

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Section: Discussionmentioning

confidence: 99%

Subretinal Tissue Glue Injection in Surgery of Macular Detachment Associated With Congenital Optic Disc Pit

Jurowski¹,

Górnik²

2016

J Clin Exp Ophthalmol

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“…110 Another novel method describes drainage of subretinal fluid through the optic disc pit to flatten the macula intraoperatively and then applying Tisseel fibrin sealant on the optic disc to seal it. 111 …”

Section: ' Optic Pitmentioning

confidence: 97%

Congenital Optic Nerve Malformations

Nicholson¹,

Ahmad²,

Sears³

2011

International Ophthalmology Clinics

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“…However, Coleman et al also found that the glue was unable to seal large retinal tears and stressed that the tissue glue alone was not enough to ensure permanent retinal reattachment 82. Al Sabti et al used Tisseel fibrin sealant to seal optic disc pit-associated macular detachment in two out of three patients for at least 3 years 83. This required patients to stay in prone position for 2 weeks postoperatively.…”

Section: Retina Surgerymentioning

confidence: 99%

Surgical adhesives in ophthalmology: history and current trends

et al. 2018

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Tissue adhesives are gaining popularity in ophthalmology, as they could potentially reduce the complications associated with current surgical methods. An ideal tissue adhesive should have superior tensile strength, be non-toxic and anti-inflammatory, improve efficiency and be cost-effective. Both synthetic and biological glues are available. The primary synthetic glues include cyanoacrylate and the recently introduced polyethylene glycol (PEG) derivatives, while most biological glues are composed of fibrin. Cyanoacrylate has a high tensile strength, but rapidly polymerises upon contact with any fluid and has been associated with histotoxicity. Fibrin induces less toxic and inflammatory reactions, and its polymerisation time can be controlled. Tensile strength studies have shown that fibrin is not as strong as cyanoacrylate. While more research is needed, PEG variants currently appear to have the most promise. These glues are non-toxic, strong and time-effective. Through MEDLINE and internet searches, this paper presents a systematic review of the current applications of surgical adhesives to corneal, glaucoma, retinal, cataract and strabismus surgeries. Our review suggests that surgical adhesives have promise to reduce problems in current ophthalmic surgical procedures.

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Management of Optic Disk Pit–associated Macular Detachment With Tisseel Fibrin Sealant

Abstract: Our case series suggest that Tisseel fibrin sealant in conjunction with pars plana vitrectomy can be used successfully for management of optic pit disk-associated macular detachments.

Cited by 25 publications

References 6 publications

Subretinal Tissue Glue Injection in Surgery of Macular Detachment Associated With Congenital Optic Disc Pit

Subretinal Tissue Glue Injection in Surgery of Macular Detachment Associated With Congenital Optic Disc Pit

Congenital Optic Nerve Malformations

Surgical adhesives in ophthalmology: history and current trends

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