Management of nontuberculous mycobacterial infection in the elderly

Mirsaeidi, Mehdi; Farshidpour, Maham; Ebrahimi, Golnaz; Aliberti, Stefano; Falkinham, Joseph O.

doi:10.1016/j.ejim.2014.03.008

Cited by 50 publications

(41 citation statements)

References 110 publications

(113 reference statements)

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“…Immunocompromised patients are particularly vulnerable and develop disseminated disease. Other known risk factors include cystic fibrosis, chronic obstructive pulmonary disease (COPD), silicosis, and alpha-1 antitrypsin deficiency [7-12]. Recent studies have also found an association between non-CF bronchiectasis and non-tuberculous mycobacterial infections [13].…”

Section: Introductionmentioning

confidence: 99%

Gender susceptibility to mycobacterial infections in patients with non-CF bronchiectasis

Mirsaeidi

Sadikot

2015

International Journal of Mycobacteriology

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Non-tuberculous mycobacteria (NTM) are environmental microbes that cause a variety of diseases both in immunocompromised and immunocompetent patients. Epidemiologic data indicate that there has been a global rise in the incidence of NTM infections. It has also been noted that NTM infections have a predilection to occur in postmenopausal women. In a recent study, it was demonstrated that in patients with non-CF bronchiectasis the probability of NTM isolation was significantly higher in elderly female patients and in those with a low body mass index. However, the mechanisms of causality of these gender differences and morpho-phenotypes remain enigmatic. The present study reviews the data and plausible mechanisms which might provide clues to this gender susceptibility and morphophenotypes of patients with bronchiectasis and NTM.

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Section: Introductionmentioning

confidence: 99%

Gender susceptibility to mycobacterial infections in patients with non-CF bronchiectasis

Mirsaeidi

Sadikot

2015

International Journal of Mycobacteriology

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“…In the analysis of clinical data, we found that patients with the Type II genotype tended to be younger than those with the Type I genotype. Evidence that increasing age is one of the most important risk factors of NTM infections (25)(26)(27)(28), supports the higher virulence potential of the Type II genotype over Type I. Generally, a pronounced difference is found in treatment success between M. abscessus subspecies, particularly between M. abscessus and M. massiliense.…”

Section: Discussionmentioning

confidence: 85%

Mycobacterium massiliense Type II genotype leads to higher level of colony forming units and TNF‐α secretion from human monocytes than Type I genotype

Kim

Shim

et al. 2015

APMIS

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Recently, we introduced a novel Mycobacterium massiliense Type II genotype from Korean patients, in which all isolates showed only a rough (R) colony morphotype. In this study, we sought to compare clinical factors and virulence potentials of two genotypes of M. massiliense, Type I and Type II. Patients infected with Type II tend to be younger at infection than those infected with Type I (56.7 vs 62.3, p = 0.051). Type II was more significantly related to R colony type than Type I (34.1% vs 94.1%, p < 0.001). The Type II strain showed significantly more colony forming units (CFUs) and higher levels of TNF-α secretion in infection of human monocytes than the Type I strain. The challenge of extracted glycopeptidolipid (GPL) into human monocytes indicated that the loss of GPL from the cell wall of the Type II genotype led to a higher level of TNF-α secretion in a toll-like receptor 2(TLR2)-dependent manner. Taken together, our data suggest that the M. massiliense Type II genotype shows higher virulence than Type I, which may be due to the induction of TNF-α via the loss of GPL from the Type II cell wall.

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“…The incidence of infections resulting in significant mortality and morbidity rates has increased over the past decade (3). Moreover, their incidence is expected to increase until 2050, given the growing geriatric population and higher prevalence of nontuberculous mycobacterial infections among this population (4).…”

Section: Introductionmentioning

confidence: 99%

Nontuberculous Mycobacterial Infection in a Patient Diagnosed with Ankylosing Spondylitis

Dirican¹,

Pinar²,

Erturk³

et al. 2016

Erciyes Med J

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Nontuberculous mycobacteria are common microorganisms in nature and are particularly found in soil and water. They cause pulmonary infections, lymphadenitis, disseminated infections, localized skin and soft tissue infections, tendon-bone-articular infections, and catheter infections. Mycobacterium xenopi is categorized as a slow-growing mycobacterium. Pulmonary infections caused by M. xenopi have been found to be associated with chronic obstructive pulmonary disease (COPD), underlying diseases such as bronchiectasis, and immunosuppression. This article aims to present an atypical mycobacterial infection in a patient in whom anti-tumor necrosis factor alpha therapy was being planned and who was followed up with diagnoses of ankylosing spondylitis and COPD.

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Management of nontuberculous mycobacterial infection in the elderly

Cited by 50 publications

References 110 publications

Gender susceptibility to mycobacterial infections in patients with non-CF bronchiectasis

Gender susceptibility to mycobacterial infections in patients with non-CF bronchiectasis

Mycobacterium massiliense Type II genotype leads to higher level of colony forming units and TNF‐α secretion from human monocytes than Type I genotype

Nontuberculous Mycobacterial Infection in a Patient Diagnosed with Ankylosing Spondylitis

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