Management of new-onset epilepsy in the elderly

Arain, Amir; Abou‐Khalil, Bassel

doi:10.1038/nrneurol.2009.74

Cited by 38 publications

(30 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[20] Tedavide eski kuşak antiepileptiklerden difenilhidantoin, karbamazepin ve sodyum valproat; yeni kuşak antiepileptiklerden ise gabapentin, levetirasetam, lamotrijin, okskarbazepin, topiramat, zonizamid tercih edilmektedir. [21,22] Antiepileptik tedavi kullanımları açısından olgular incelendiğinde en sık kullanılan tedavinin difenilhidantoin (%44) ve karbamazepin (%32) olduğu, bunları sırasıyla okskarbazepin (%16), lamotrijin (%8), levetirasetam (%16), gabapentin (%8) ve valproatın (%25) izlediği görülmüştür.…”

Section: Discussionunclassified

Experiences in an Epilepsy Polyclinic: Epilepsy in the Elderly

Özkan¹

2015

Epilepsi

View full text Add to dashboard Cite

SummaryObjectives: Epilepsy is one of the most common serious neurological disorders in the elderly. In this study the demographic and clinical features, etiological factors, seizure types and response ratios to treatment are presented for a group of patients aged 60 years and over diagnosed with epilepsy.Results: Twenty-five patients aged 60 years and over who applied to the epilepsy polyclinic were retrospectively investigated.Results: Average patient age was 75.0±7.1 years and average disease duration was 2.32±1.8 years. Sixteen patients were male and 9 female. Among the patients, cerebrovascular disease (17 patients), brain tumor (1 patient), arachnoid cyst (1 patient), aneurysm (1 patient) and myocardial infarction (1 patient) were considered as the underlying factors in seizure development. In the remaining 4 cases, no etiological cause was determined. Seizure types were; secondary generalized tonic-clonic seizure (20 patients), simple partial seizure (2 patients), status epilepticus seizure (2 patients), and complex partial seizure (1 patient). EEG findings were abnormal in 32% of the patients (n=8). When evaluated for treatment, 18 patients received monotherapy; 6 patients used double, and 1 patient used triple drugs. The follow-up period in 21 cases was without seizure. Conclusion:In the study, the most common etiological cause of epilepsy seen in the elderly was cerebrovascular disease. Seizure type was mainly secondary generalized tonic-clonic. The patients responded well to monotherapy and prognosis was improved.

show abstract

Section: Discussionunclassified

Experiences in an Epilepsy Polyclinic: Epilepsy in the Elderly

Özkan¹

2015

Epilepsi

View full text Add to dashboard Cite

show abstract

“…It is also necessary, in consultation with a physician before conception begin taking folic acid, to the first weeks of pregnancy reduce the harmful effects of antiepileptic drugs [6,7,8].…”

Section: Discussionmentioning

confidence: 99%

Congenital Malformations in Newborns of Mothers Affected by Epilepsy

Jovandaric¹

2015

Clinics Mother Child Health

View full text Add to dashboard Cite

Aim: To examine the effects of anti-epileptic drugs (AED) used during pregnancy on the frequency and the type of congenital malformations in newborns. Methods:The study included 96 newborns, born by mothers affected by epilepsy (before the pregnancy). The control group consisted of 96 healthy newborns delivered by mothers.Results: Almost all of the pregnant women used AED (98%) during the pregnancy. Monotherapy (Phenobarbiton) was used in 80% of women and 18% was used polytherapy, respectively. The pregnancy ended vaginal delivery in 54.4% of women, and in 45.5% of women, it is ended by cesarean section. Congenital malformations (palatoshisis and ventricular septal defect-VSD) were observed after births in 3 of newborn by means of detailed clinical and ehosonographic survey. Both pregnant women were on polytherapy (Phenobarbiton and Karbamazepin). Congenital malformations were not observed in the control group of newborns delivered by healthy mothers. Conclusion:The use of AED in the form of monotherapy and avoiding of AED that have the teratogenic effect are recommended during the pregnancy. Mothers with epilepsy are free to continue with the breast feeding their newborns.

show abstract

“…[1,2] Yaşlı hastalarda epilepsiler etiyolojik faktörler açısından da genç hastalardan daha farklıdır ve yaşlılarda eşlik eden hastalıklar nedeniyle farmakolojik etkileşimler de önemlidir. [3,4] Bu çalışmada, kliniğimiz epilepsi polikliniğinde takip edilen epilepsi hastaları içinde yaşları 65 üzerinde olanlar çalışma-ya alındı ve nöbet tipi, etiyoloji, tedavi ve prognoz açısından incelendi.…”

Section: Introductionunclassified

Epilepsy profile in elderly patients

Mısırli¹,

Erdoğan²,

Tunali³

et al. 2014

Epilepsi

View full text Add to dashboard Cite

SummaryObjectives: The incidence of epilepsy is high among elderly patients and rises up as the population gets older. The seizure semiology is different than the younger adults and difficult to recognize. In this study, we investigated the specialities of the epileptic seizures in the patients older than 65 years old. Methods: We analyzed retrospectively 196 patients who are older than 65 years old and were followed in the outpatient epilepsy clinic for at least two years. Results: In 196 patients, 80 had focal seizures, 102 had jeneralized seizures and 14 had undefined seizures. Post-stroke seizures in 112 patients were at the first line in etiology. Seizures were responsive to treatment as monotherapy in 148 patients and as politherapy in 48 patients. Conclusion: Instead of recognizing difficultly the seizures in the elderly, the treatment control is not hard and monotherapy is enough for many patients.Key words: Epilepsy; seizure type; treatment; elderly patients. ÖzetAmaç: Yaşlı hastalarda epilepsi insidansı nüfusun yaşlanmasıyla birlikte gittikçe artmaktadır. Genç erişkinlere göre nöbet semiyolojisi daha farklıdır ve nöbetlerin tanınması zordur. Bu çalışmada 65 yaş üzerindeki epilepsi nöbetlerinin özellikleri araştırıldı. Gereç ve Yöntem:Epilepsi polikliniğine başvuran ve yaşları 65 üstünde olan, en az iki yıldır izlenen 196 hasta geriye dönük olarak araştırıldı.Bulgular: Yüz doksan altı hastanın 80'i fokal, 102'si jeneralize, 14'ü belirlenemeyen tipte nöbeti vardı. Etiyolojide ilk sırayı 112 hasta ile inme sonrası nöbetler aldı. Yüz kırk sekiz hastada monoterapi, 48 hastada politerapi ile nöbetler kontrol altında idi. Sonuç:Yaşlı hastalarda nöbetler zor tanınmasına rağmen uygun tedavi ile kontrolleri zor değildir ve çoğu monoterapi ile iyi seyrederler.

show abstract

Management of new-onset epilepsy in the elderly

Cited by 38 publications

References 82 publications

Experiences in an Epilepsy Polyclinic: Epilepsy in the Elderly

Experiences in an Epilepsy Polyclinic: Epilepsy in the Elderly

Congenital Malformations in Newborns of Mothers Affected by Epilepsy

Epilepsy profile in elderly patients

Contact Info

Product

Resources

About