Management of new onset anosmia during the COVID pandemic - BRS Consensus Guidelines

Hopkins, Claire; Alanin, Mikkel Christian; Philpott, Carl; Harries, Philip G.; Whitcroft, Katherine L.; Qureishi, Ali; Anari, Shahram; Ramakrishnan, Yujay; Sama, Anshul; Davies, Elgan; Stew, Benjamin; Gane, Simon; Carrie, Sean; Hathorn, Iain; Bhalla, Raj; Kelly, Christine; Hill, Nina; Boak, Duncan; Kumar, B. Nirmal

doi:10.22541/au.159015263.38072348

Cited by 5 publications

(8 citation statements)

References 4 publications

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“…The Exerscent device might facilitate olfactory research in several ways. First, smell training conducted outside of the lab could be valuable as a therapeutic intervention to counter smell loss, for example, due to coronavirus infection (Gerkin et al, 2020;Hopkins et al, 2020). Here, the Exerscent digital interface will enable more sophisticated data collection and user feedback, and more flexible task designs.…”

Section: Discussionmentioning

confidence: 99%

A Method for Computerized Olfactory Assessment and Training Outside of Laboratory or Clinical Settings

Niedenthal¹,

Nilsson

Jernsäther

et al. 2021

i-Perception

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There are currently few ways to reliably and objectively assess olfaction outside of the research laboratory or clinic. The COVID-19 pandemic has highlighted the need for remote olfactory assessment; in particular, smell training at home is a promising method for olfactory rehabilitation, but further methodological advances might enhance its effectiveness and range of use. Here, we present Exerscent, a portable, low-cost olfactory display designed primarily for uses outside of the laboratory and that can be operated with a personal computer. Exerscent includes Radio Frequency Identification (RFID) tags that are attached to odor stimuli and read with a MFRC522 module RFID reader/antenna that encodes the odor in order to provide adaptive challenges for the user (e.g., an odor identification task). Hardware parts are commercially available or 3D printed. Instructions and code for building the Exerscent are freely available online ( https://osf.io/kwftm/ ). As a proof of concept, we present a case study in which a participant trained daily to identify 54 odors, improving from 81% to 96% accuracy over 16 consecutive days. In addition, results from a laboratory experiment with 11 volunteers indicated a very high level of perceived usability and engagement. Exerscent may be used for olfactory skills development (e.g., perfumery, enology), and rehabilitation purposes (e.g., postviral olfactory loss), but it also allows for other forms of technological interactions such as olfactory-based recreational interactions.

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Section: Discussionmentioning

confidence: 99%

A Method for Computerized Olfactory Assessment and Training Outside of Laboratory or Clinical Settings

Niedenthal¹,

Nilsson

Jernsäther

et al. 2021

i-Perception

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“…We suggest four primary research application areas for the Exerscent device. First, smell training conducted outside of the lab could be valuable as a therapeutic intervention to counter smell loss due to COVID-19 symptoms and other anosmias (Gerkin et al, 2020;Hopkins et al, 2020). Here, the Exerscent digital interface will enable more sophisticated data collection and user feedback, and more flexible task designs.…”

Section: Discussionmentioning

confidence: 99%

“…Prior studies have shown sensory benefits of smell training after postviral olfactory loss (Hummel et al, 2009;Sorokowska et al, 2017). Smell training has been recommended as a means to recover olfaction following COVID-19 (Hopkins et al, 2020). Smell training has also shown to enhance olfactory perception and cognition, and arguably even non-olfactory cognitive abilities, suggesting a wide range of applications (Birte-Antina et al, 2018;Olofsson et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

A method for computerized olfactory assessment and training outside of laboratory or clinical settings

Niedenthal¹,

Nilsson²,

Jernsäther³

et al. 2020

Preprint

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There are currently few ways to reliably and objectively assess olfaction outside of the research laboratory or clinic. Smell training is a promising method for olfactory rehabilitation at home, but further methodological advances might enhance itseffectiveness and range of use. Here we present Exerscent, a portable, low-cost olfactory display designed primarily for uses outside of the laboratory and that can be operated witha personal computer. Exerscent includes RFID tags that are attached to odor stimuli using a sensor box that encodes the odor in order to provide adaptive challenges for the user(e.g. an odor identification task). Hardware parts are commercially available or 3D printed. Instructions and code for building the Exerscent is freely available online(https://osf.io/kwftm/). As a proof of concept, we present a case study in which a participant trained daily to identify 54 odors, improving from 81% to 96% accuracy over 16 consecutive days. Exerscent may be primarily used for olfactory skills development (e.g. perfumery, enology), and rehabilitation purposes (e.g. postviral olfactory loss), butit also allows for other forms of technological interactions such as olfactory-based recreational interactions. We discuss how Exerscent and similar methods might enablewidespread, networked olfactory research in a variety of settings, including homes, elder care facilities and schools.

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“…SARS-CoV-2 virusas ne išimtis. Pastarasis infekuoja ląsteles pasinaudodamas angiotenziną I konvertuojančio fermento 2 (AKF2) receptoriais ir ląstelių paviršiaus proteazėmis TMPRSS2 [8]. Kelios studijos teigia, jog nosies kvėpuojamojo epitelio ląstelės pasižymi didesne AKF2 receptorių ir TMPRSS2 genų raiška, nei trachėjoje ar plaučiuose [9], todėl būtent nosies epitelis yra pagrindinis viruso rezervuaras užsikrėtus koronavirusu.…”

Section: Tyrimo Rezultatai Ir Diskusijaunclassified

“…Šios ląstelės tiesiogiai atsakingos už hematoencefalinį barjerą, vietinio kraujagyslių tonuso palaikymą ir neuroimuninį atsaką [12]. Tai leidžia manyti, jog virusas, patekęs į pericitus, gali tiesiogiai (dėl perfuzijos pokyčių) arba netiesiogiai (dėl uždegimo) paveikti chemosensorinį suvokimą smegenyse [8]. Bandant išsiaiškinti, ar CO-VID-19 virusas gali tiesiogiai paveikti CNS neuronus, kyla daug diskusijų, tačiau iš esmės virusas turi galimybę patekti į smegenis net keliais skirtingais būdais per kraujagysles, nervus, kurie inervuoja infekuotus audinius, ir tiesiogiai per nosį (akytąją plokštelę).…”

Section: Vaizdo Tyrimaiunclassified

Uoslės Sutrikimai Ir Covid-19

Liugas¹,

Kindurytė²,

Eitavičiūtė³

et al. 2021

Health Sciences

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Uoslės sutrikimas stipriai paveikia pacientų kasdienio gyvenimo kokybę. Šios patologijos priežastys gali būti įvairios, tačiau pastaraisiais metais pasauliui gyvenant COVID-19 pandemijos sąlygomis, pastebėta, kad nemaža dalis šia infekcija sergančių pacientų skundžiasi uoslės sutrikimu ar visišku jos išnykimu. Tyrimo tikslas − apžvelgti uoslės sutrikimų, atsirandančių sergant COVID-19, epidemiologiją, patofiziologiją, diagnostiką, gydymą bei prognozę. Išplitęs organizme SARS-CoV-2 užkratas paveikia uodžiamojo epitelio ląsteles ir, turima duomenų, jog pažeidžia uodžiamąjį stormenį. Uoslės sutrikimo diagnostikai gali būti naudojami įvairūs objektyvūs ir subjektyvūs testai. Uoslės sutrikimą, pasireiškusį sergančiajam COVID-19 infekcija, reikia diferencijuoti su nosies ir prienosinių ančių, potrauminiu bei neurodegeneraciniu uoslės pažeidimais. Tikėtina, jog bendrosios povirusinių uoslės sutrikimų gydymo metodikos yra naudingos ir tinkamos COVID-19 sukelto uoslės sutrikimo gydymui: aromaterapija, natrio citratas, vietiškai nosyje naudojamas A vitaminas bei teofilinas, sisteminės omega-3 polinesočiosios riebalų rūgštys. Dažniausiai uoslės sutrikimai visiškai atsikuria per kelias savaites, tačiau retais atvejais gali užtrukti iki poros mėnesių po pasveikimo.

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Management of new onset anosmia during the COVID pandemic - BRS Consensus Guidelines

Cited by 5 publications

References 4 publications

A Method for Computerized Olfactory Assessment and Training Outside of Laboratory or Clinical Settings

A Method for Computerized Olfactory Assessment and Training Outside of Laboratory or Clinical Settings

A method for computerized olfactory assessment and training outside of laboratory or clinical settings

Uoslės Sutrikimai Ir Covid-19

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