Management of neural tube defects in a Sub-Saharan African country: The situation in Yaounde, Cameroon

Djientcheu, Vincent de Paul; Njamnshi, Alfred K.; Wonkam, Ambroise; Njiki, Julie; Guemse, Mohamadou; Mbu, Robinson Enow; Obama, Marie-Thérèse; Takongmo, S.; Kago, I.; Ekoe, Tetanye; Tietche, F

doi:10.1016/j.jns.2008.07.003

Cited by 38 publications

(38 citation statements)

References 9 publications

(28 reference statements)

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“…These results are similar to those obtained by Njamnshi et al [9] who found that MMC represented 68.11% of cases. Similarly, Alatise et al [7] in 2006 reported that myelomeningocele was the most common clinical type (86.8%).…”

Section: Clinical Types Of Neural Tube Defectssupporting

confidence: 92%

“…No case of anencephaly was found during this period. This rarity of anencephaly as also reported by Njamnshi KA and his collaborators in a cross-sectional retrospective study at the neonatology unit of the mother and child center-Yaounde, [9] does not necessarily reflect its true incidence since a large proportion of anencephalic babies are aborted spontaneously or die immediately after birth. Moreover, anencephalic babies born in other health care institutions may not have been referred to the Douala General Hospital for management since it is known that, this particular type of neural tube defect is incompatible with life.…”

Section: Clinical Types Of Neural Tube Defectsmentioning

confidence: 71%

“…Out the 49 patients enrolled, there were 29 (59.2%) males and 20 (48.8%) females with a male-to-female ratio of 1.5 in favour of males. Njamnshi KA and his collaborators in a cross-sectional retrospective study at the neonatology unit of the mother and child center-Yaounde in 2008, [9] reported a male predominance (69.57%) in their sample. These results are at variance with those obtained by Sanoussi et al [11], Kabre et al [13].…”

Section: Long Term Clinical Outcome Of the Patientsmentioning

confidence: 99%

“…These results were similar to those obtained by Alatise and his collaborators [7] at the pediatric surgery and neurosurgical units of Obafemi Awolowo university in Nigeria, who reported that the commonest site of the lesions was lumbosacral (55.7%). Many other studies [9] [10] reported that lumbosacral MMC was the commonest clinical type of spina bifida aperta. These figures are in agreement with literature reports.…”

Section: Site Of the Lesionsmentioning

confidence: 99%

“…In Cameroon, the incidence of NTD was 1.99/1000 births in 2008 [9]. A case of tethered cord syndrome (TCS) in an adult was reported in 2014 [10].…”

Section: Introductionmentioning

confidence: 99%

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Pattern and Management of Neural Tube Defect in Cameroon

Motah¹,

Moumi²,

Ndoumbe³

et al. 2017

OJMN

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Objectives: The aim of study was to determine the pattern and management of neural tube defects (NTD). Methodology: It was a hospital based descriptive cross-sectional retrospective study on patients who consulted and/or were admitted at the Douala General hospital for neural tube defects from January 2005 to April 2015. Results: A total of forty-nine (49) patients were enrolled. Males constituted 59.8% and females 40.2% giving a sex ratio of 1.5 in favour of males. Most of the parents of the patients (71.5%) had a low socio-economic status. Myelomeningocele was the most common type (80.4%) followed by 17.4% cases of meningocele and 2.2% cases of lipomeningocele. Three cases (3) of encephaloceles were seen during this period. The commonest site of these defects was the lumbosacral region (47.8%). Other sites included lumbar (19; 41.3%), sacral (3; 6.5%) and thoracolumbar (2; 4.3%) ones. About half of the patients (24; 48.9%) presented with ruptured lesions. Hydrocephalus was also recorded in 65.3% of patients. Talipes equinovarus and talipes calcaneovalgus were the most common associated orthopedic birth defects found. Surgical closure was done for 44 (89.9%) patients. Ventriculoperitoneal shunting was done in 78.1% of those who presented with hydrocephalus. Post-operative complications were more frequent in patients with ruptured lesions (P = 0.001). The most common post-operative complications were wound infections (22; 44.9%) and wound dehiscence (20; 40.8%). Conclusion: Lumbosacral Myelomeningocele was the most common type of NTD in our region. Low socio-economic status was a common risk factor.

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Section: Clinical Types Of Neural Tube Defectssupporting

confidence: 92%

Section: Clinical Types Of Neural Tube Defectsmentioning

confidence: 71%

Section: Long Term Clinical Outcome Of the Patientsmentioning

confidence: 99%

Section: Site Of the Lesionsmentioning

confidence: 99%

“…In Cameroon, the incidence of NTD was 1.99/1000 births in 2008 [9]. A case of tethered cord syndrome (TCS) in an adult was reported in 2014 [10].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Pattern and Management of Neural Tube Defect in Cameroon

Motah¹,

Moumi²,

Ndoumbe³

et al. 2017

OJMN

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Central nervous system congenital malformations in a developing country: issues and challenges against their prevention

2010

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Little or no attention is currently paid to the prevention of CNS congenital anomalies in much of the low- and middle-income countries of the world. There is a great need to regulate the practice of obstetric ultrasonography in Nigeria. There is even a much greater, more fiercely urgent need to ensure periconceptional folic acid supplementation for all women of childbearing age through appropriate food fortification in these societies.

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Hydrocephalus in toddlers: the place of shunts in sub-Sahara African countries

et al. 2011

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Cases of hydrocephalus in toddlers are frequent in our setting. Regardless of the patient's age, the most prevailing aetiologies (infections, haemorrhage, myelomeningocele) and technological conditions (neuroendoscope) are less favourable for ETV. The use of ETV in the treatment of hydrocephalus in sub-Saharan Africa is still marginal and needs to be encouraged in selected cases. The prevention of non-tumoral hydrocephalus is of critical importance.

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Management of neural tube defects in a Sub-Saharan African country: The situation in Yaounde, Cameroon

Cited by 38 publications

References 9 publications

Pattern and Management of Neural Tube Defect in Cameroon

Pattern and Management of Neural Tube Defect in Cameroon

Central nervous system congenital malformations in a developing country: issues and challenges against their prevention

Hydrocephalus in toddlers: the place of shunts in sub-Sahara African countries

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