Management of Nail Unit Melanoma

Zhang, Junqian; Yun, Sook Jung; McMurray, Stacy L.; Miller, Christopher J.

doi:10.1016/j.det.2020.12.006

Cited by 23 publications

(23 citation statements)

References 60 publications

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“…Diversos autores apresentaram bons resultados terapêuticos e ausência de recidivas. Estudos demonstram que não foram observadas diferenças estatísticas na taxa de recorrência local dos melanomas subungueais in situ quando submetidos à cirurgia funcional comparado às amputações (ZHANG, et al, 2021).…”

Section: Discussionunclassified

Interrelações Da Violência, Transtornos Mentais Comuns E Ideação Suicida

Sales¹,

Macena²

2022

Medicina: Campo Teórico, Métodos E Geração De Conhecimento 5

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Direitos para esta edição cedidos à Atena Editora pelos autores. Open access publication by Atena Editora Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação com base em critérios de neutralidade e imparcialidade acadêmica.A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação, evitando plágio, dados ou resultados fraudulentos e impedindo que interesses financeiros comprometam os padrões éticos da publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

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Section: Discussionunclassified

Interrelações Da Violência, Transtornos Mentais Comuns E Ideação Suicida

Sales¹,

Macena²

2022

Medicina: Campo Teórico, Métodos E Geração De Conhecimento 5

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“…The amputation of a digit at the MCPJ level reportedly resulted in 40% (thumb), 20% (index or middle finger), and 10% (ring or little finger) impairment of hand function, whereas loss at the DIPJ level led to only half of the functional impairment of that at the MCPJ level 76 . Therefore, non‐amputation functional surgery (FS) has become the standard of care for NMIS or shallow‐depth NM since sparing the phalanx during amputation preserves limb function and leads to improved cosmetic outcomes without decreasing survival rates 3,4,77–80 …”

Section: Managementmentioning

confidence: 99%

“…76 Therefore, non-amputation functional surgery (FS) has become the standard of care for NMIS or shallow-depth NM since sparing the phalanx during amputation preserves limb function and leads to improved cosmetic outcomes without decreasing survival rates. 3,4,[77][78][79][80] Nail melanoma invasion depth should guide the surgical approach. FS is the treatment of choice for the NMIS (Fig.…”

Section: Managementmentioning

confidence: 99%

Diagnosis and treatment of nail melanoma: a review of the clinicopathologic, dermoscopic, and genetic characteristics

Darmawan

Ohn

Mun

et al. 2022

Acad Dermatol Venereol

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Nail melanoma (NM) is an important differential diagnosis in patients with longitudinal melanonychia. However, diagnosis is often challenging as it is difficult to differentiate from other pigmented nail disorders. The main challenge for diagnosis is obtaining adequate nail matrix biopsy specimens for histopathological assessment. Furthermore, the histopathological changes in the early stages of NM are subtle and contribute to a delay in diagnosis and care. Therefore, the integration of clinical and histopathological analyses is essential. Clinical and dermoscopic features, such as a broadened width of asymmetric bands in an irregular pattern, with multicolour pigmentation, periungual pigmentation, and continuous growth, are features that support the diagnosis of NM. The essential histological features that must be assessed are cellular morphology, architectural features, melanocyte density, and inflammatory changes. The reported mutations in NMs were BRAF (0–43%), NRAS (0–31%), KIT (0–50%), NF1 (0–50%), and GNAQ (0–25%). Surgery is the primary treatment for NM. The recommended treatment for in situ or minimally invasive NM is functional surgery, but cases with suspected bone invasion should be treated with amputation. Targeted therapy and immunotherapy are indicated for advanced stages of NM. This review summarizes the updated guidelines for the diagnosis and treatment of NM.

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“…The introduction of immune checkpoint inhibitors has changed the management of metastatic melanoma. However, lower response rates to immune checkpoint blockades have been observed in acral melanoma and nail unit melanoma, which may be due to smaller numbers of tumor-infiltrating lymphocytes, lower PD-L1 expression, and a lower mutational burden in acral melanoma compared with other subtypes of melanoma [ 71 ].…”

Section: Acral Melanomamentioning

confidence: 99%

Acral Melanocytic Neoplasms: A Comprehensive Review of Acral Nevus and Acral Melanoma in Asian Perspective

Park

Yun

2022

Dermatopathology

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Acral melanocytic neoplasms, including acral melanocytic nevus and acral melanoma, are common melanocytic lesions in Asian populations. Both lesions occur on the volar surface of the hands and feet, and on nail units. Acral melanocytic nevi occur on the arch area of the sole, whereas acral melanomas frequently occur on weight-bearing areas of the sole, and on the fingernails. Therefore, the development of acral melanoma may be associated with chronic pressure, physical stress, or trauma. Dermoscopy is a useful adjunctive diagnostic tool for differential diagnosis. Acral melanocytic nevus is characterized by a parallel furrow pattern, whereas acral melanoma has a parallel ridge pattern. Genetic alterations are also different between the two types of lesion. BRAF and NRAS mutations are common in acral melanocytic nevus, whereas acral melanoma shows lower rates of KIT, NF1, BRAF, and NRAS mutations and remarkable copy number variations in genes such as CCND1, CDK4, hTERT, PAK1, and GAB2. Sentinel lymph node biopsy is important for staging and prognosis. Contemporary treatments for melanoma include targeted therapy for mutations and immunotherapy, such as anti-PD1 inhibitors.

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Management of Nail Unit Melanoma

Cited by 23 publications

References 60 publications

Interrelações Da Violência, Transtornos Mentais Comuns E Ideação Suicida

Interrelações Da Violência, Transtornos Mentais Comuns E Ideação Suicida

Diagnosis and treatment of nail melanoma: a review of the clinicopathologic, dermoscopic, and genetic characteristics

Acral Melanocytic Neoplasms: A Comprehensive Review of Acral Nevus and Acral Melanoma in Asian Perspective

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