Management of Muscle Invasive Bladder Cancer with Bladder Preservation in Russia: a Survey-Based Analysis of Current Practice and the Impact of an Educational Workshop on Clinical Expertise

Mitin, Timur; Dengina, Natalia; Черных, М. В.; Usychkin, Sergey; Gladkov, Oleg; Degnin, Catherine; Chen, Yiyi; Nosov, Dmitry; Tsimafeyeu, Ilya; Thomas, Charles R.; Tjulandin, Sergei

doi:10.1007/s13187-020-01728-y

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…Опрос относительно различных аспектов органосохраняющего лечения МИРМП в России был осуществлен в рамках ежегодного конгресса Российского общества клинической онкологии (RUSSCO) в 2018 г. [59]. Он показал, что 78,3 % респондентов считают оправданным назначение НХТ перед ТМТ у пациентов с местно-распространенными формами РМП (Т3N0M0 и более).…”

Section: рис 1 варианты взаимоотношений опухолевого процесса устья и ...unclassified

Guideline on trimodal therapy of bladder cancer (Nevskiy consensus 2021)

Novikov

Новиков

et al. 2022

Onkourologiâ

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The aim of this work was to clarify and extend the existing clinical guidelines on organ-sparing treatment of muscleinvasive bladder cancer. The standard protocol of radical conservative treatment for muscle-invasive bladder cancer includes transurethral resection of the bladder, external beam radiotherapy with simultaneous chemotherapy (radiosensitization), which is usually referred to as trimodal therapy. The implementation of trimodal therapy into routine practice in Russia is limited due to the lack of distinct criteria for each of the stages. The involvement of surgeons, radiation oncologists, and chemotherapists, on the one hand, provides the required multidisciplinary approach to cancer treatment; on the other hand, it might impede the entire algorithm. To address this problem, specialists from the Department of Radiology (project moderators), Department of Cancer Urology, and Department of Chemotherapy of N.N. Petrov National Medical Research Center of Oncology under the auspices of Saint Petersburg Oncological Research Society formed a group of experts, including radiation oncologists, urologists, and chemotherapists from federal and local cancer (educational) institutions of Saint Petersburg who had an experience of treating muscle-invasive bladder cancer. The guideline was developed with the consideration of available guidelines published by leading professional associations of radiotherapy and oncology (urological), research articles, and own experience.

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Section: рис 1 варианты взаимоотношений опухолевого процесса устья и ...unclassified

Guideline on trimodal therapy of bladder cancer (Nevskiy consensus 2021)

Novikov

Новиков

et al. 2022

Onkourologiâ

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“… 3 Unfortunately, sexual dysfunction and treatment options following RC are rarely discussed with the patients. 4 , 5 Additionally, high-quality prospective research concerning sexual health and its impact on QoL following RC in the treatment of BC is rare and urgently needed. 6–12 The data situation in special patient groups, such as elderly patients and women, is even worse.…”

Section: Introductionmentioning

confidence: 99%

Prospective evaluation of sexual health following radical cystectomy due to bladder cancer

Nolting,

Nitzsche,

Kiss

et al. 2024

Sexual Medicine

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Background There is a lack of data concerning sexual health following open radical cystectomy (RC), especially in elderly patients and women. Aim To describe sexual health and its impact on general health as well as survival in patients undergoing standard open RC for the treatment of bladder cancer (BC). Due to limited data, subgroup analysis for elderly patients and women was performed. Methods A prospective noninterventional clinical study was performed evaluating sexual health in RC with any kind of urinary diversion due to BC with a follow-up of 12 months after RC. The study was approved by the local ethics review board (A 2021-0175) and was registered at the German Clinical Trial Register (DRKS00026255). Assessment of sexual health was done with the following validated questionnaires: EORTC QLQ-C30 (for quality of life; European Organisation for Research and Treatment of Cancer), EORTC SH22 (for sexual health), and IIEF-5 (5-item International Index of Erectile Function). Outcomes The standard measurements of EORTC QLQ-C30, EORTC SH22, and IIEF-5 as well as overall survival. Results Thirty-two patients participated in the study with a mean age of 71.5 years (SD, 9.7): 25 (78.1%) were male and 7 (21.9%) were female. Overall there is a heterogenic picture for sexual health in the study population, but sexual satisfaction is significantly higher prior to surgery while the importance of a sex life stays high and stable. Interestingly, the general health score is significantly correlated to sexual satisfaction (Pearson’s correlation; r = 0.522, P = .002) preoperatively but not following surgery: r = 0.103 (P = .665) after 3 months, r = 0.478 (P = .052) after 6 months, r = 0.276 (P = .302) after 9 months, and r = 0.337 (P = .202) after 12 months. The importance of a sex life is still essential for the patients, especially when recovering from RC; nearly the same can be reported for elderly patients. Unfortunately, the data for women are too limited to report robust results. Clinical Implications Evaluation, advice, and monitoring of sexual health must be integrated into clinical practice, particularly in women. Strengths and Limitations At least to our knowledge, this is the first systematic prospective evaluation of sexual health in patients with BC receiving RC. Due to the small sample size, there is a risk of selection bias. Conclusion Sexual health is important for patients with BC receiving RC, and it is an essential part of quality of life, especially in elderly patients.

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“…For patients that are medically unsuitable for RC, or those who prefer non-surgical alternatives, RT and concurrent chemotherapy are currently the most effective treatments. For suitable surgical candidates, bladder conservation can maintain function and result in similar oncologic outcomes to RC ( 7 ). However, the resistance of cancer cells to radiation often limits the effectiveness of RT.…”

Section: Introductionmentioning

confidence: 99%

STAT3 enhances radiation-induced tumor migration, invasion and stem-like properties of bladder cancer

Wang

Mao

et al. 2020

Mol Med Rep

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Bladder cancer (BCa) is the most common cancer of the human urinary system, and is associated with poor patient prognosis and a high recurrence rate. Cancer stem cells (CSCs) are the primary cause of tumor recurrence and metastasis, possessing self-renewal properties and resistance to radiation therapy. Our previous studies indicated that phosphorylated signal transduction and transcription activator 3 (STAT3) may be a potential biomarker to predict radiation tolerance and tumor recurrence in patients with BCa, following conventional radiotherapy. The aim of the present study was to investigate the underlying mechanism of STAT3 in the radio-resistance of BCa cells. It was found that fractionated irradiation promoted the activation of two STAT3-associated CSCs signaling pathways in BCa cells, namely suppressor of variegation 3-9 homolog 1/GATA binding protein 3/STAT3 and Janus kinase 2/STAT3. Surviving cells exhibited elevated migratory and invasive abilities, enhanced CSC-like characteristics and radio-resistance. Furthermore, knockdown of STAT3 expression or inhibition of STAT3 activation markedly decreased the self-renewal ability and tumorigenicity of radiation-resistant BCa cells. Kaplan-Meier analysis revealed that decreased STAT3 mRNA levels were associated with increased overall survival times in patients with BCa. Taken together, these data indicated that STAT3 may be an effective therapeutic target for inhibiting the progression, metastasis and recurrence of BCa in patients receiving radiotherapy.

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Management of Muscle Invasive Bladder Cancer with Bladder Preservation in Russia: a Survey-Based Analysis of Current Practice and the Impact of an Educational Workshop on Clinical Expertise

Cited by 5 publications

References 24 publications

Guideline on trimodal therapy of bladder cancer (Nevskiy consensus 2021)

Guideline on trimodal therapy of bladder cancer (Nevskiy consensus 2021)

Prospective evaluation of sexual health following radical cystectomy due to bladder cancer

STAT3 enhances radiation-induced tumor migration, invasion and stem-like properties of bladder cancer

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