Abstract:Multiple myeloma is a neoplastic proliferation of a plasma cell clone that produces a monoclonal immunoglobulin. It is one of the most common haematological malignancies and the incidence increases with age, with a median age at diagnosis of 65-70 years. The diagnosis of multiple myeloma requires the presence of ࣙ10% plasma cells in the bone marrow and an M-protein in serum and/or urine. Cytogenetic status, serum β 2 -microglobulin and response to therapy are the key prognostic factors. Treatment is necessary … Show more
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