Management of Mild-to-Moderate Hypertriglyceridemia

Pulipati, Vishnu Priya; Brinton, Eliot A.; Hatipoğlu, Betül

doi:10.1016/j.eprac.2022.07.003

Cited by 5 publications

(3 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The treatment of F-HTG focuses on the reduction of low-density lipoprotein (LDL) cholesterol levels, followed by management of non–high-density lipoprotein cholesterol levels; this can be achieved by changes in lifestyle and dietary modifications [ 126 ] or by the administration of statins such as Atorvastatin, Lovastatin, Fluvastatin, Pravastatin Rosuvastatin and Simvastatin [ 127 ]. Fibrates [ 128 ], Niacin [ 129 ] and Fish oil [ 126 , 130 , 131 ], The development of alternatives to statins, which include Evinacumab, the angiotensin-like 2 monoclonal antibody [ 132 ], which has shown adequate safety in trials [ 133 ]. The resurgence of approval for monoclonal antibody treatments for rare disorders [ 134 ] and gene therapy in animal models [ 135 ] will set the direction for the advancement of therapeutics for the management of this emerging disorder.…”

Section: Familial Hypertriglyceridemiamentioning

confidence: 99%

Current Understanding on the Genetic Basis of Key Metabolic Disorders: A Review

Rodrigues

Yong

Bhuiyan

et al. 2022

Biology

View full text Add to dashboard Cite

Advances in data acquisition via high resolution genomic, transcriptomic, proteomic and metabolomic platforms have driven the discovery of the underlying factors associated with metabolic disorders (MD) and led to interventions that target the underlying genetic causes as well as lifestyle changes and dietary regulation. The review focuses on fourteen of the most widely studied inherited MD, which are familial hypercholesterolemia, Gaucher disease, Hunter syndrome, Krabbe disease, Maple syrup urine disease, Metachromatic leukodystrophy, Mitochondrial encephalopathy lactic acidosis stroke-like episodes (MELAS), Niemann-Pick disease, Phenylketonuria (PKU), Porphyria, Tay-Sachs disease, Wilson’s disease, Familial hypertriglyceridemia (F-HTG) and Galactosemia based on genome wide association studies, epigenetic factors, transcript regulation, post-translational genetic modifications and biomarker discovery through metabolomic studies. We will delve into the current approaches being undertaken to analyze metadata using bioinformatic approaches and the emerging interventions using genome editing platforms as applied to animal models.

show abstract

Section: Familial Hypertriglyceridemiamentioning

confidence: 99%

Current Understanding on the Genetic Basis of Key Metabolic Disorders: A Review

Rodrigues

Yong

Bhuiyan

et al. 2022

Biology

View full text Add to dashboard Cite

show abstract

“…Hypertriglyceridemia is a common metabolic condition, with an estimated prevalence of 26% in the US adult population, or 12.3 million people, affecting predominantly white males [ 14 ]. The principal risk factors are obesity, sedentarism and diabetes [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Hypertriglyceridemia-Induced Acute Pancreatitis—The Milky Way Constellation—The Seven-Year Experience of a Large Tertiary Centre

Edu,

Pahomeanu,

Ghiță

et al. 2024

Diagnostics

View full text Add to dashboard Cite

(1) Background: Hypertriglyceridemia (HTG) is a well-known metabolic condition associated with an increased risk of acute pancreatitis. In this study, we tried to establish whether there are any significant disparities concerning recurrence rate, intensive care unit (ICU) admission, hospital (ICU and total) length of stay (LoS), morphology, severity and age between HTG-induced acute pancreatitis and any other known cause of pancreatitis (OAP). (2) Methods: The research was a retrospective unicentric cohort study, using information from the Bucharest Acute Pancreatitis Index (BUC-API) registry, a database of 1855 consecutive cases of acute pancreatitis. (3) Results: We found a weak association between HTG-AP and recurrence. The HTG-AP patients were younger, with a median of 44.5 years, and had a longer ICU stay than the OAP patients. In addition, we identified that the HTG-AP patients were more likely to develop acute peripancreatic fluid collection (APFC), to be admitted in ICU, to have a more severe course of disease and to be cared for in a gastroenterology ward. (4) Conclusions: Hypertriglyceridemia-induced APs have a more severe course. The typical patient with HTG-AP is a middle-aged male, with previous episodes of AP, admitted in the gastroenterology ward, with a longer ICU stay and longer length of hospitalization, more likely to evolve in a severe acute pancreatitis (SAP) and with a higher probability of developing APFC.

show abstract

“…therapy, aimed at caloric and fat intake restriction, and pharmacological therapy are used to prevent the onset of acute pancreatitis [19][20][21], especially in severe HTG. However, the threshold of TG levels that increase the risk of developing acute pancreatitis, TG levels requiring aggressive therapeutic intervention, and target therapeutic levels remain unclear.…”

mentioning

confidence: 99%

Characterization of patients with acute idiopathic pancreatitis using an administrative claims database in Japan

Imura

Katada

2023

Preprint

View full text Add to dashboard Cite

Background: Hypertriglyceridemia is one of the causes of idiopathic acute pancreatitis and atherosclerotic cardiovascular diseases. Most guidelines define fasting triglyceride levels greater than 150 mg/dL as hypertriglyceridemia; however the triglyceride level of patients with acute pancreatitis is not clear, nor is it known how much triglyceride level reduction can reduce cardiovascular events. This study aimed to characterize patients with acute idiopathic pancreatitis and especially focused on triglyceride levels, patient characteristics, pharmaceutical treatment, and prognosis. Methods: In this retrospective analysis of an administrative claims database, patients hospitalized due to acute pancreatitis were selected, and idiopathic pancreatitis was identified using specific pre-determined ICD-10 codes. A Wilcoxon rank sum test was performed for the comparison of the means of the two cohorts, and Fisher's exact test was used to compare proportions between the cohorts. The comparison between idiopathic and non-idiopathic pancreatitis was performed using a log-rank test. Results: Between April 1, 2008, and July 31, 2021, 44,005 patients were hospitalized for the treatment of pancreatitis; among them, 30,814 cases (70.0%) were categorized as idiopathic. The mean age of patients with idiopathic pancreatitis was 62.7±18.8 years, 68.8% of the patients were male, and the mean triglyceride levels within 3 days after hospitalization were 293.1±816.6 mg/dL. Rehospitalization due to recurrent pancreatitis and the incidence rates of cardiovascular events were 39.5% and 3.3%, respectively. Conclusions: Patients with idiopathic pancreatitis had elevated triglyceride levels at admission. Even if triglyceride levels are not extremely high, hypertriglyceridemia might cause idiopathic pancreatitis. Therefore, there is a need for intervention in terms of triglyceride levels in patients with hypertriglyceridemia, not only to prevent cardiovascular disease, but also to prevent the onset and recurrence of acute pancreatitis. Trial registration: Not applicable

show abstract

Management of Mild-to-Moderate Hypertriglyceridemia

Cited by 5 publications

References 64 publications

Current Understanding on the Genetic Basis of Key Metabolic Disorders: A Review

Current Understanding on the Genetic Basis of Key Metabolic Disorders: A Review

Hypertriglyceridemia-Induced Acute Pancreatitis—The Milky Way Constellation—The Seven-Year Experience of a Large Tertiary Centre

Characterization of patients with acute idiopathic pancreatitis using an administrative claims database in Japan

Contact Info

Product

Resources

About