Management of melanotic neuroectodermal tumor of infancy

Oliveira, Márcia Gaiger de; Thompson, Lester D.�R.; Chaves, Anna Cecília Moraes; Rados, Pantelis Varvaki; Lauxen, Isabel da Silva; Filho, Manoel Sant’Ana

doi:10.1053/j.anndiagpath.2004.04.003

Cited by 49 publications

(60 citation statements)

References 19 publications

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“…This tumor usually appears in children under the age of 1 year [4,5], with an approximately equal distribution between the sexes [4,6]. Normally it arises in the head and neck region, mainly affecting the maxilla, although other sites, such as the brain, epididymis [7], mediastinum, femur and ovary [8,9] may be affected.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, no tissue similar to that of the sclera was identified, and the eyes of these patients are generally normal. Therefore, the majority of authors believe that the tumor originates from neural crest cells [1,3,5,[8][9][10].…”

Section: Discussionmentioning

confidence: 99%

“…In patients with elevated levels, the vanillylmandelic acid levels generally return to normal after the tumor is excised, which provided more support for this theory [15]. Additional support for the neuroectodermal derivation is the expression of melanotransferrin in MNTI [9,22]. Microscopically, MNTIs are biphasic tumors composed of small-cell and large-cell components, arranged in nestlike or alveolar formations embedded within a well-vascularized fibrous stroma.…”

Section: Discussionmentioning

confidence: 99%

“…The neuroectodermal melanocytic tumor of infancy is a benign neoplasm, but in 7 % of the cases reported, metastatic appearances were located in various anatomic points of the human body, generally under the definition of recurrent disease [9,24,25]. Clinical and histological risk factors and the interval between initial treatment and development of metastatic disease were not characterized in the literature [25].…”

Section: Discussionmentioning

confidence: 99%

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Extensive Melanotic Neuroectodermal Tumor of Infancy

Albuquerque

Cunha

Avelar

et al. 2015

Head and Neck Pathol

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The melanotic neuroectodermal tumor of infancy (MNTI) is a rare childhood neoplasm with an alarming but classical clinical presentation. We present the case of a 2-month-old male infant treated with surgery for an aggressive MNTI on the alveolar process of the maxilla. Radiographic examination showed a diffuse osteolytic radiolucent lesion in the right maxilla, and displacement and dysmorphic changes in the developing primary tooth buds. The patient remained well without evidence of recurrence for 6 months after surgery. We discussed clinicopathological features, management alternatives, and outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Extensive Melanotic Neuroectodermal Tumor of Infancy

Albuquerque

Cunha

Avelar

et al. 2015

Head and Neck Pathol

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“…Melanotic neuroectodermal tumor of infancy (MNTI) is a rare neoplasm of neural crest origin, which is composed of relatively primitive pigment-producing cells and usually arises in infants within the first year of life [2,7]. No gender predilection has been described [4,7].…”

Section: Introductionmentioning

confidence: 99%

Melanotic neuroectodermal tumor of infancy: a case report

2008

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Melanotic neuroectodermal tumor of infancy (MNTI) is a rare pigmented tumor generally occurring in the head and neck region in children 12 months of age or younger. Approximately 380 instances of this tumor are reported in the medical literature. We presented a case of MNTI that occurred in the left temporal bone of a 2-month old female infant. And, the clinical assessment, histologic diagnosis, and management is reviewed.

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