Management of Lifestyle Factors in Individuals with Cirrhosis: A Pragmatic Review

Tandon, Puneeta; Berzigotti, Annalisa

doi:10.1055/s-0039-1696639

Cited by 15 publications

(17 citation statements)

References 103 publications

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“…Our study indicated that alcohol use attributed LC deaths doubled from 1990 to 2019, whereas the related ASDR slightly decreased during this period. This discrepancy might be the result of the acceleration of population aging worldwide [21,22]. Globally, alcohol consumption is roughly consistent with the distribution of alcohol use-related LC burden [24].…”

Section: Discussionmentioning

confidence: 66%

Burden of Liver Cancer Attributable to Five Risk Factors by Specific Etiologies in 204 Countries and Territories

Wei

Deng

et al. 2021

Preprint

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Background Liver cancer has caused a serious disease burden worldwide wherein prognostic risk factors may have had a significant role. However, previous studies have focused on liver cancer distributions and trend variations without analyzing the role of risk factors. Methods We assessed liver cancer burden attributable to five recognized risk factors as well as temporal trends from 1990 to 2019 based on the 2019 Global Burden of Disease Study. The risk exposure levels and their contributed burden were estimated by cause, sex, age, and location. Furthermore, the relationship between the risks and social-demographic index (SDI) was investigated. Results The total liver cancer burden attributable to risk factors is still increasing year by year in terms of death and disability-adjusted life years. However, the burden attributable to alcohol use and smoking has shown a downward trend in recent years. Risk-related burden in males was more than three times as that in females, the burden among the middle-aged and elderly was the most serious, and Central Asia, high-income Asia Pacific and East Asia exhibited the highest burden worldwide. The exposure levels of the five recognized risk factors were generally positively correlated with SDI value. However, the risk-related liver cancer burden first increased and then decreased with the SDI value. Conclusion These findings could help in understanding the role of prognostic risk factors in liver cancer burden, in promoting the development of relevant studies, and in proposing better prevention and control policies tailored to local conditions.

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Section: Discussionmentioning

confidence: 66%

Burden of Liver Cancer Attributable to Five Risk Factors by Specific Etiologies in 204 Countries and Territories

Wei

Deng

et al. 2021

Preprint

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“…Currently, there are few therapeutic opportunities for liver fibrosis and the introduction of efficient options needs to be addressed. Suppression of viruses, dietary alterations, decreasing body weight in NAFLD, and induction of fibrosis regression are proposed to stop the disease progression (Kohla et al, 2020;Sheka et al, 2020;Tandon and Berzigotti, 2020). The current clinical trials mostly did not focus on the direct modification of the mechanisms of the disease progressions but investigated other mechanistic approaches such as the causative agents in the underlying liver damage, the received signals from other organs, metabolic pathways, immune system, and cell death processes.…”

Section: Molecular Mechanism Of Liver Fibrosis and Recent Clinical Trialsmentioning

confidence: 99%

The Potential Application of Magnetic Nanoparticles for Liver Fibrosis Theranostics

et al. 2021

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Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic liver damage and leading to cirrhosis, liver cancer, and liver failure. To date, there is no effective and specific therapy for patients with hepatic fibrosis. As a result of their various advantages such as biocompatibility, imaging contrast ability, improved tissue penetration, and superparamagnetic properties, magnetic nanoparticles have a great potential for diagnosis and therapy in various liver diseases including fibrosis. In this review, we focus on the molecular mechanisms and important factors for hepatic fibrosis and on potential magnetic nanoparticles-based therapeutics. New strategies for the diagnosis of liver fibrosis are also discussed, with a summary of the challenges and perspectives in the translational application of magnetic nanoparticles from bench to bedside.

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“…The risk of developing sarcopenia is associated with male gender, ascites, and the degree of renal and hepatic dysfunction[ 9 ]. Overweight and obesity are as frequent as in general population, ranging from 20% to 40% and aggravating prognosis both in compensated and in decompensated cirrhosis[ 11 ]. Sarcopenic obesity (coexistence of sarcopenia and obesity) is present in one-fifth to one-third of patients with cirrhosis.…”

Section: Clinical Significance and Consequences Of Sarcopeniamentioning

confidence: 99%

Muscular abnormalities in liver cirrhosis

Hari

2021

WJG

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Sarcopenia is becoming a well-established player in evaluating patients with chronic liver disease. Data regarding its clinical significance and consequences in the course of liver disease have been growing; many of the data support the idea that it impacts decompensation event frequency, prolonged hospitalization, and mortality, as well as providing the possibility to better prioritize patients on lists awaiting liver transplantation. When assessing the whole clinical scope of the field, which includes malnutrition and frailty, as well as the complete spectrum of muscle mass, strength, and function, it becomes clear that a well-founded approach in everyday clinical practice is essential. In this respect, this article attempts to unveil the most recently published data regarding possible methods and modalities that could be used to diagnose sarcopenia as early as possible, along with the required accuracy and reliability. From the most important field discoveries to data that need further clarification, the merits and weaknesses of the very diverse existing evaluation methods are presented. Finally, a critical overview is given, in an attempt to discern study lines of importance from those that could pose further ambiguity for the theme. The author also poses relevant questions that remain unanswered but are of clinical importance in the field.

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Management of Lifestyle Factors in Individuals with Cirrhosis: A Pragmatic Review

Cited by 15 publications

References 103 publications

Burden of Liver Cancer Attributable to Five Risk Factors by Specific Etiologies in 204 Countries and Territories

Burden of Liver Cancer Attributable to Five Risk Factors by Specific Etiologies in 204 Countries and Territories

The Potential Application of Magnetic Nanoparticles for Liver Fibrosis Theranostics

Muscular abnormalities in liver cirrhosis

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