Management of leg ulcers with hydrocolloid occlusive dressing

Friedman, S. J.

doi:10.1001/archderm.120.10.1329

Cited by 40 publications

(37 citation statements)

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“…An ideal wound dressing is one, which induces host cells to regenerate, prevent infection, act like an osmotic regulator, 1 providing optimal environment for healing to take place quickly. 2 Although occlusive dressings possess clinical benefit in treatments of wounds, 3,4 they may provide a favorable environment for the microflora of wound to further proliferate and grow. 5 Microbes, entering the wound, delay healing by initiating infection, leading to wound fluid exudation, and have a number of deleterious effects on the healing process.…”

Section: Introductionmentioning

confidence: 99%

Design and delivery of silver sulfadiazine from alginate microspheres‐impregnated collagen scaffold

et al. 2005

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A reconstituted collagen scaffold impregnated with silver sulfadiazine (SSD) loaded alginate microspheres, capable of delivering the drug in a controlled manner has been developed. SSD-loaded alginate microspheres were prepared by modified water-in-oil emulsion technique through interfacial ionic gelation of alginate using CaCl2. The SSD-loaded microspheres were impregnated in pepsin-solubilized collagen, in situ, while inducing fibrillation and cast as thin scaffold. Morphological features of microspheres and microsphere-impregnated collagen were analyzed through SEM. Distribution homogeneity of impregnated microspheres, their in vitro behavior in (Dulbecco's modified minimal essential media) DMEM, and antibacterial efficiency against ATCC pathogens were determined. Initial drug load of 20% (w/w) with respect to alginate and 40% (v/v) of 2% alginate with respect to oil phase were found to produce microspheres of optimum drug entrapment (3%) and required size range (300-370 microm). In vitro drug release studies from the scaffold showed an initial burst release of 47.5% and a controlled release for 72 h with equilibrium concentration of 68.8%. SSD-loaded microspheres exhibited minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) levels of 32 and 40.2 microg/mL to both K. pneumoniae and E. coli respectively. P. aeruginosa showed MIC and MBC levels of 44.8 and 51.2 microg/mL respectively, while Staphylococcus aureus exhibited MIC and MBC at the same concentration range (57.6 microg/mL). The collagen-based scaffold impregnated with SSD-loaded alginate microspheres can deliver SSD in a controlled fashion, can control infection for extended time period with lesser dressing frequencies, and will enable easier assessment of wound.

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Section: Introductionmentioning

confidence: 99%

Design and delivery of silver sulfadiazine from alginate microspheres‐impregnated collagen scaffold

et al. 2005

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“…62 It also occludes the wound, prevents exposure of denuded nerve terminals to air, and, thus, mitigates the tingling characteristic of shallow wounds. 63 • Commercially available HD materials, which are translucent and allow observation of the wound after application, include DuoACTIVE â ET. Visiderm â (a translucent and waterproof polyurethane film using HD in the layer adhering to the skin) and Remois â Pad (a transparent polyurethane film having a 3-layer structure with the layer adhering to the skin being HD compounded with moisture-retaining ceramide 2, supportive layer above it being a polyurethane film, and the outermost layer above it being very slippery nylon knit with a low friction coefficient) may also be used, though they are not medical materials.…”

Section: Pressure Ulcer In the Acute Phase Cq10: What Topical Treatmementioning

confidence: 99%

“…82 It further occludes the wound, prevents exposure of denuded nerve terminals to air, and, thus, reduces the tingling characteristic of shallow wounds. 83…”

Section: Cq13: What Measures Should Be Taken When Dti Is Suspected?mentioning

confidence: 99%

“…296 HD also occludes the wound and prevents exposure of denuded nerve terminals to air, thus, mitigating the tingling characteristic of shallow wounds. 297 • There are three RCT using hydrogel for pressure ulcers in the red-white stages. [283][284][285] No significant difference was observed in the cure rate compared with saline gauze dressing 283,284 or HD.…”

Section: Cq29: What Dressing Materials Should Be Used For Topical Trementioning

confidence: 99%

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The wound/burn guidelines – 2: Guidelines for the diagnosis and treatment for pressure ulcers

Tachibana

Imafuku

Irisawa

et al. 2016

The Journal of Dermatology

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The Wound/Burn Guidelines Committee consists of members commissioned by the Board of Directors of the Japanese Dermatological Association (JDA). It held several meetings and evaluations in writing since October 2008, and drafted five guidelines for the diagnosis and treatment including commentaries on wounds in general and the Guidelines for the Diagnosis and Treatment for Pressure Ulcers by taking opinions of the Scientific Committee and Board of Directors of JDA into consideration.Key words: body position changes, nutritional support, pressure ulcer, reactive erythema, skin care.Correspondence: Hironobu Ihn, M.D., Ph.D., Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan. Email: ihn-der@kumamoto-u.ac.jp This is the secondary English version of the original Japanese manuscript for The wound/burn guidelines -2: Guidelines for the diagnosis and treatment for pressure ulcers published in

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“…One of these dressings is the hydrocolloid dressing. [3][4][5][6][7][8] These opaque, absorbent dressings consist of hydrocolloid granules embedded in an adhesive matrix covered by a polyurethane foam. In the Western world, these dressings are now widely used in the management of (leg) ulcers.…”

Section: Introductionmentioning

confidence: 99%

Tolerability and efficacy of hydrocolloid dressings in the treatment of venous leg ulcers under tropical conditions: an open prospective study

Langenberg

Fat

et al. 2001

Acad Dermatol Venereol

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General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Dermatology, Academic Hospital Paramaribo, Paramaribo, Surinam. * Corresponding author, tel. +31 20 5662587; fax +31 20 6960076; E-mail: j.e.zeegelaar@amc.uva.nl ABSTRACTIn the Western world, hydrocolloid dressings are widely used in wound treatment. However, little is known about their tolerability and efficacy under tropical conditions. The purpose of this study was to assess the tolerability and efficacy of a hydrocolloid dressing in combination with short stretch compressive bandages under tropical conditions. Seventeen patients with venous leg ulcers attending an outpatient clinic in Surinam were enrolled in the study for a period of 6 weeks. Swabs for bacterial cultures were taken at the beginning and end of the study. All ulcers showed a good healing tendency. Percentage of granulation tissue in the ulcers improved from mean 27% at start to 92% at the end. Mean circumference at start was 9.9 cm, at the end 4.9 cm. Exudation diminished from moderate in six and severe in eight ulcers, to moderate in 10 and almost none in two ulcers. In general, the dressing was very well accepted, pain was never reported. Leakage was noticed 39 times in the 164 dressing changes. This study revealed no differences in the rate of bacterial infections or colonization of wounds compared with studies performed in temperate regions. Our data indicate that hydrocolloid dressings can be used under tropical conditions.

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Management of leg ulcers with hydrocolloid occlusive dressing

Cited by 40 publications

References 0 publications

Design and delivery of silver sulfadiazine from alginate microspheres‐impregnated collagen scaffold

Design and delivery of silver sulfadiazine from alginate microspheres‐impregnated collagen scaffold

The wound/burn guidelines – 2: Guidelines for the diagnosis and treatment for pressure ulcers

Tolerability and efficacy of hydrocolloid dressings in the treatment of venous leg ulcers under tropical conditions: an open prospective study

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