Management of Late Relapses After Chemotherapy in Testicular Cancer: Optimal Outcomes with Dose-intense Salvage Chemotherapy and Surgery

Alifrangis, Constantine; Lucas, Olivia; Benafif, Sarah; Ansell, Wendy; Greenwood, Michelle; Smith, Shievon; Wilson, Peter; Thomas, Benjamin; Mazhar, Danish; Berney, Dan; Shamash, Jonathan

doi:10.1016/j.euf.2020.04.001

Cited by 7 publications

(2 citation statements)

References 19 publications

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“…Tumours originate from germinal tissue to rate 90%-95%. 9 Although most germ-cell tumours are highly curable, it is stated that a small proportion of patients usually experience relapse within 2 years 10,11 and the late relapse rate is between 1.4% and 3.2%. 10 TC, which is the most common type of cancer seen among young men in western countries, is one of the most treatable tumours in terms of 10-year survival rates (90%-95%).…”

Section: Introductionmentioning

confidence: 99%

Beliefs and behaviours of students in health‐related faculties regarding testicular self‐examination

Karazeybek

Özdemir

Temür

et al. 2021

Int J of Uro Nursing

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What are the beliefs and behaviours of men students attending health-related faculties at a university regarding testicular self-examination? This study was conducted with the aim of identifying the approaches of men students attending health-related faculties at a university towards testicular self-examination, determining their levels of awareness of testicular self-examination and contributing to early diagnosis of testicular tumours. Testicular cancer is a disease that can result in death if not diagnosed early, but high treatment success rates can be achieved if diagnosed early. Lack of knowledge related to the risks created by testicular cancer and to testicular selfexamination, which is very important for early diagnosis in young men, is revealed to be among the reasons for delay in diagnosis and treatment. The study was conducted between September and November 2019 in health-related faculties of a state university in southern Turkey. The study universe consisted of a total of 370 men students studying in fourth grade in health-related faculties nursing, medicine and dentistry. A 'Descriptive Characteristics Form' and 'Champion's Health Belief Model Scale' were used as data collection tools. Percentage, Levene's test, one-way analysis of variance (ANOVA), chi-square and eta squared were used to evaluate the data. While 59.6% of students in the nursing faculty stated that they had previously received information related to testicular self-examination, 72% of students in the medical faculty and 67.7% of students in the dentistry faculty stated that they had not previously received information about this issue. Among students in the nursing faculty who had received information, it was determined that 75.0% had learnt about it in lessons and that 45.9% had performed testicular self-examination. Regarding the arithmetic means of the sub-dimension scores of the Champion's Health Belief Model Scale according to faculty attended, there was a significant difference in the benefits (F (2,168) = 4.915; p = 0.08), barriers (F(2,168) = 4.831; p = 0.09) and self-efficacy/ confident (F(2,168) = 5.816; p = 0.04) sub-dimensions. The study revealed that testicular self-examination implementation rates and attitudes towards testicular selfexamination among university students studying at health-related faculties were low.

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Section: Introductionmentioning

confidence: 99%

Beliefs and behaviours of students in health‐related faculties regarding testicular self‐examination

Karazeybek

Özdemir

Temür

et al. 2021

Int J of Uro Nursing

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“…In late relapse cases, where relapse occurs after two years of disease-free, most of it was recognized by the increase in AFP serum level. 35 Only 10% of patients with NSGCTs have a rise in β-hCG serum level whereby 76 to 52 per cent others dominate in elevation of AFP level. These values can be explained by the discovery of which the most frequent germ cell tumors in patients with relapse are yolk sac tumour.…”

Section: Application Of Tumor Markers In Testicular Neoplasm Relapse Detectionmentioning

confidence: 99%

The key application of serum tumor markers in testicular cancer: a review and update

et al. 2021

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Testicular neoplasm is the most common solid tumor in male. The recent advancement in the medical field has made it possible to become one of the most highly treatable neoplasms. Testicular neoplasm is mainly classified into two main groups: non-seminomatous germ cell tumor and seminomatous germ cell tumor. In this review article, we analyzed the current role of serum biomarkers in diagnosis, prognosis, staging, measurement of response to therapy and early detection of relapse of testicular neoplasm. The commonly used tumor markers are alpha-fetoprotein (AFP), beta-human chorionic gonadotrophins and lactate dehydrogenase. Apart from them, a new set of tumor biomarkers like placentallike alkaline phosphatase, gammaglutamyltranspeptidase, miRNA, mitochondrial DNA and serum trace elements are also proven to be potentially helpful in the management of testicular neoplasm. Progressive elevation of serum tumor markers often indicates the presence of testicular cancer and aids in histological classifications. According to an additional category, the rate of elevation of respective biomarkers is advantageous to appropriately stage testicular neoplasm (S) in the tumor nodes metastases (TNM) staging classification. Besides, it is found that higher elevation of serum tumor markers is associated with a poorer prognosis. Post-treatment assessment where there is a rate of reduction of serum tumour biomarkers suggests the effectiveness of initial management of testicular neoplasm.

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Antibody Drug Conjugates in Urological Cancers: A Review of the Current Landscape

Ghose,

Lapitan,

Apte

et al. 2024

Curr Oncol Rep

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Management of Late Relapses After Chemotherapy in Testicular Cancer: Optimal Outcomes with Dose-intense Salvage Chemotherapy and Surgery

Cited by 7 publications

References 19 publications

Beliefs and behaviours of students in health‐related faculties regarding testicular self‐examination

Beliefs and behaviours of students in health‐related faculties regarding testicular self‐examination

The key application of serum tumor markers in testicular cancer: a review and update

Antibody Drug Conjugates in Urological Cancers: A Review of the Current Landscape

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