Management of Lacrimal Gland Carcinoma

Woo, Kyung In; Yeom, Arim; Esmaeli, Bita

doi:10.1097/iop.0000000000000531

Cited by 40 publications

(39 citation statements)

References 38 publications

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“…The most common benign tumor of the lacrimal gland is the pleomorphic adenoma, while the adenoid cystic carcinoma (ACC) is the most common malignant tumor[7,9,11]. Therefore, most studies on epithelial tumors of the lacrimal gland have been predominantly on ACC[12,13]. The subtypes of lacrimal gland carcinoma, other than ACC, are very rare and sebaceous carcinoma is one of the rarest tumor among them[12].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, most studies on epithelial tumors of the lacrimal gland have been predominantly on ACC[12,13]. The subtypes of lacrimal gland carcinoma, other than ACC, are very rare and sebaceous carcinoma is one of the rarest tumor among them[12]. It has been studied only through several case series.…”

Section: Discussionmentioning

confidence: 99%

“…The optimal treatment of SCLG is difficult to study due to its rare incidence[12]. SCLG has so far been treated by surgical excision[3].…”

Section: Discussionmentioning

confidence: 99%

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Primary sebaceous carcinoma of lacrimal gland: A case report and review of literature

Park

Choi

2018

WJCC

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BACKGROUNDPrimary sebaceous carcinoma of lacrimal gland (SCLG) is extremely rare. Due to its clinical characteristics, it is often misdiagnosed. It is known to be aggressive so delay in diagnosis can increase the chance of local recurrence and metastasis. We report a case of primary SCLG.CASE SUMMARYA 75-year-old man was referred with a painful swelling in the right eyelid. Computed tomography scan demonstrates a 2.6 cm mass in upper outer quadrant of right orbit. After the incisional biopsy of the mass, he was diagnosed with squamous cell carcinoma of lacrimal gland. A right orbital exenteration, cervical lymph node dissection was performed. There was no involvement of the overlying periorbital skin, eyelid, or conjunctiva. Histological examination of the exenteration specimen showed tumor arising from the lacrimal gland, which had been entirely replaced by sebaceous carcinoma with sarcomatous and squamous differentiation. Neoplastic cells which were large and contained prominent nucleoli. Focal tumor remained in the posterior resection margin. Patient underwent adjuvant radiotherapy, total dose of 56 Gy with dose-per-fraction 2 Gy to primary lesion. There has been no sign of recurrence until 2-years follow-up.CONCLUSIONWe report a rare case of sebaceous carcinoma arising from the lacrimal gland. Accurate diagnosis of SCLG is important for appropriate treatment and prognosis prediction.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary sebaceous carcinoma of lacrimal gland: A case report and review of literature

Park

Choi

2018

WJCC

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“…The primary treatment for benign lacrimal gland tumors is surgical resection, whereas malignant tumors are generally removed surgically followed by radiotherapy and/or chemotherapy [8]. Hadron beam therapy has also been considered a nonsurgical treatment option for patients not suitable for surgical treatment [9]. However, there is some controversy surrounding therapeutic options, particularly for malignant tumors.…”

Section: Introductionmentioning

confidence: 99%

Loss of BRCA1 Spontaneously Induces the Tumorigenesis in Lacrimal Gland

Kim

Baek

Park

et al. 2018

Analytical Cellular Pathology

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Environmental and genetic factors exert important influences on lifespan and neoplastic transformation. We have previously shown that spontaneous tumors form frequently in mice homozygous for a full-length Brca1 deletion. In general, mutations of BRCA1 are closely associated with induction of breast and ovarian cancers but are also known to contribute to the incidence of other cancers at a low frequency. Female Brca1-mutant mice (Brca1co/coMMTV-cre) were generated by crossing Brca1 conditional knockout mice and MMTV-cre mice, and the occurrence of lacrimal gland abnormalities and tumors was followed until mice reached 18 months of age. Lacrimal gland tumors, which occur at a very low frequency in the human population (1 per 1,000,000 per year), were detected in 7 cases of Brca1co/coMMTV-cre mice (2.75%) older than 9 months of age. None of seven mice exhibited any abnormality in the mammary gland including neoplasia, suggesting lacrimal gland tumor is spontaneously and independently formed. These tumors, which were detected in seven mutant mice that displayed exophthalmoses, were malignant, originated from epithelial cells, and were identified as acinic cell carcinoma by pathological analysis. Further analysis revealed that tumorigenesis was accompanied by the accumulation of cyclin D1 and decreased expression of the cellular oncogenes, c-Myc, c-Jun, and c-Raf. Tumors also exhibited rearrangement of cytoskeletal proteins, including β-catenin, keratin 5, and vimentin, depending on tumor progression. These results suggest that BRCA1 is involved in genetic stability of the lacrimal gland, providing new insight into genomic instability in organism maintenance and tumorigenesis of the lacrimal gland.

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“…As compared to other lacrimal gland carcinomas, patients with ACC of the lacrimal gland are typically diagnosed at younger ages, report earlier and more frequent periocular pain, and experience local recurrence or distant metastasis even after long quiescent periods [3]. The difficulties in localized control and the high tendency for regional recurrences in ACC are attributed to perineural infiltration and bone invasion [4]. Distant metastasis is seen in up to 50% of patients with ACC, with the lungs, bone, and liver reported as the most commonly affected sites [1,5,6,7].…”

Section: Introductionmentioning

confidence: 99%

Incidentally Discovered Adenoid Cystic Carcinoma of the Lacrimal Gland with Isolated Liver Metastases

Maamari¹,

Custer²,

Harocopos³

2017

Ocul Oncol Pathol

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Aim: To report a rare presentation of adenoid cystic carcinoma (ACC) of the lacrimal gland. Method: This is a case report presenting clinical, radiographic, and histopathologic findings. Results: A 72-year-old female with no reported ocular symptoms was found to have an incidental right orbital mass on imaging. Additional studies revealed multiple liver lesions, which were biopsied and found to be consistent with ACC. She was then referred to the ophthalmology service, where ocular examination demonstrated 2.5 mm of right proptosis with elevation and abduction deficits. Diplopia could be elicited in extreme upgaze and right lateral gaze. An excisional biopsy of the orbital mass was performed, with histopathology confirming the diagnosis of primary ACC of the lacrimal gland, thereby also supporting the initial suspicion that the hepatic ACC lesions represented metastases. Conclusion: The authors describe a rare presentation of ACC of the lacrimal gland, initially asymptomatic, with metastatic lesions restricted to the liver at the time of diagnosis. Three previous cases of ACC with isolated metastatic hepatic lesions at the time of diagnosis have been reported; all of these cases localized the primary tumor to the salivary glands.

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Management of Lacrimal Gland Carcinoma

Abstract: Given the rarity of lacrimal gland carcinoma, multi-institutional studies and consistent reporting of size and histologic type of tumors in the literature may be prudent. Particularly, multimodality globe-sparing treatment strategies should be studied further.

Cited by 40 publications

References 38 publications

Primary sebaceous carcinoma of lacrimal gland: A case report and review of literature

Primary sebaceous carcinoma of lacrimal gland: A case report and review of literature

Loss of BRCA1 Spontaneously Induces the Tumorigenesis in Lacrimal Gland

Incidentally Discovered Adenoid Cystic Carcinoma of the Lacrimal Gland with Isolated Liver Metastases

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