Management of iron deficiency and anemia after Roux-en-Y gastric bypass surgery: An observational study

Malone, Margaret; Alger-Mayer, Sharon; Lindstrom, Jennifer H.; Bailie, George R.

doi:10.1016/j.soard.2013.01.019

Cited by 25 publications

(23 citation statements)

References 22 publications

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“…Rates have been reported as ranging between 36 and 58 % in obese patients [18][19][20]. Iron deficiency anemia, however, occurs in 35 to 64 % of patients [18,19]. We found a similar rate of iron deficiency (50 %) and a corresponding significant drop of serum ferritin concentration over 24 months but slightly lower rates of anemia (23 %; Table 2).…”

Section: Discussionsupporting

confidence: 67%

“…Despite these high rates of iron deficiency and anemia, only 22 % of our patients received iron supplementation, indicating that the need to recognize and treat iron deficiency and anemia after RYGB has been underestimated, until now. Malone and colleagues reported a similar delay in recognizing and treating clinically relevant iron deficiency [18]. In addition, they and others have found that oral iron supplementation does not adequately resolve iron deficiency, due to reduced intestinal iron absorption [18,20,21].…”

Section: Discussionmentioning

confidence: 94%

“…Rates have been reported as ranging between 36 and 58 % in obese patients [18][19][20]. Iron deficiency anemia, however, occurs in 35 to 64 % of patients [18,19].…”

Section: Discussionmentioning

confidence: 99%

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Risk of Malnutrition, Trace Metal, and Vitamin Deficiency Post Roux-en-Y Gastric Bypass—a Prospective Study of 20 Patients with BMI <35 kg/m2

et al. 2015

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 94%

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Risk of Malnutrition, Trace Metal, and Vitamin Deficiency Post Roux-en-Y Gastric Bypass—a Prospective Study of 20 Patients with BMI <35 kg/m2

et al. 2015

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“…Physiologically, most iron is absorbed in the upper part of the small intestine where the intraluminal pH is relatively low; however, this segment of the small intestine is now excluded from contact with ingested food. It has been reported that up to 50% of RYGB patients may develop iron-deficient anemia if iron is not substituted appropriately (82).…”

Section: Micronutrient Status After Rygb and Rygb Effects On Bone Metmentioning

confidence: 99%

The physiology underlying Roux-en-Y gastric bypass: a status report

Lutz

Bueter

2014

American Journal of Physiology-Regulatory, Integrative and Comp

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Lutz TA, Bueter M. The physiology underlying Roux-en-Y gastric bypass: a status report. Am J Physiol Regul Integr Comp Physiol 307: R1275-R1291, 2014. First published September 24, 2014 doi:10.1152/ajpregu.00185.2014.-Obesity and its related comorbidities can be detrimental for the affected individual and challenge public health systems worldwide. Currently, the only available treatment options leading to clinically significant and maintained body weight loss and reduction in obesity-related morbidity and mortality are based on surgical interventions. This review will focus on two main clinical effects of Roux-en-Y gastric bypass (RYGB), namely body weight loss and change in eating behavior. Animal experiments designed to understand the underlying physiological mechanisms of these post-gastric bypass effects will be discussed. Where appropriate, reference will also be made to vertical sleeve gastrectomy. While caloric malabsorption and mechanical restriction seem not to be major factors in this respect, alterations in gut hormone levels are invariably found after RYGB. However, their causal role in RYGB effects on eating and body weight has recently been challenged. Other potential factors contributing to the RYGB effects include increased bile acid concentrations and an altered composition of gut microbiota. RYGB is further associated with remarkable changes in preference for different dietary components, such as a decrease in the preference for high fat or sugar. It needs to be noted, however, that in many cases, the question about the necessity of these alterations for the success of bariatric surgery procedures remains unanswered.Roux-en-Y gastric bypass; vertical sleeve gastrectomy; gut hormones; restriction; malabsorption; energy expenditure THE OBESITY EPIDEMIC AND ITS related comorbidities constitute a major challenge for both personal health and public health systems worldwide. The enormous increase in knowledge about the physiological mechanisms that control eating and body weight contrasts with the lack of available pharmacological therapies leading to safe, efficient, and long-lasting body weight reductions and amelioration of obesity-related comorbidities. However, recent insights into underlying mechanisms of obesity and bariatric surgery have led to promising perspectives in respect to gut hormone-based strategies against obesity. Nevertheless, best results for maintained weight reduction and improvement of comorbidities are still achieved by surgical means (22,88,121,135,136). This review aims to summarize key findings in respect to underlying physiological mechanisms of the Roux-en-Y gastric bypass (RYGB) procedure, which is the most commonly performed bariatric operation worldwide and thus, by many is considered as the gold standard in bariatric surgery. Sporadic reference will also be made to vertical sleeve gastrectomy (VSG) when appropriate. Both operations reduce eating at least temporarily (19,140,143) and lead to changes in food preferences (20,27,72). The majority of data collected with...

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“…On the other hand, bariatric procedures pose a higher risk of vitamins and minerals deficiencies that necessitates proper monitoring and intake of these substances after surgery [14]. The absorption of orally administered drugs, minerals and vitamins is affected [15].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Bariatric Surgery Patients in Lebanon: A Cross-Sectional Observational Study

Fahs¹,

Akel²,

Rahal³

et al. 2017

J Obes Weight Loss Ther

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Management of iron deficiency and anemia after Roux-en-Y gastric bypass surgery: An observational study

Cited by 25 publications

References 22 publications

Risk of Malnutrition, Trace Metal, and Vitamin Deficiency Post Roux-en-Y Gastric Bypass—a Prospective Study of 20 Patients with BMI <35 kg/m2

Risk of Malnutrition, Trace Metal, and Vitamin Deficiency Post Roux-en-Y Gastric Bypass—a Prospective Study of 20 Patients with BMI <35 kg/m2

The physiology underlying Roux-en-Y gastric bypass: a status report

Assessment of Bariatric Surgery Patients in Lebanon: A Cross-Sectional Observational Study

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