Management of Intracranial Metastatic Disease With Laser Interstitial Thermal Therapy

Salehi, Afshin; Kamath, Ashwin A.; Leuthardt, Eric C.; Kim, Albert H.

doi:10.3389/fonc.2018.00499

Cited by 40 publications

(28 citation statements)

References 22 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Salehi et al [40] in a study with 25 patients with BM treated with LITT established a cutoff volume of 5.62 cm 3 where patients with equal or smaller lesions had longer PFS. On a univariate analysis, the authors also reported that patients with coverage equal to 97% or lower had a significantly shorter PFS when compared to patients with greater than 97% of lesion coverage.…”

Section: The Use Of Litt To Treat Brain Metastasesmentioning

confidence: 99%

The use of laser interstitial thermal therapy in the treatment of brain metastases: a literature review

Bastos

Fuentes

Traylor

et al. 2020

International Journal of Hyperthermia

View full text Add to dashboard Cite

The aim of this paper is to discuss the current evidence for Laser Interstitial Thermal Therapy (LITT) in the treatment of brain metastases, our current recommendations for patient selection and the future perspectives for this therapy. We have also touched upon the possible complications and role of systemic therapy coupled with LITT for the treatment of brain metastases Material and Methods: Two authors carried out the literature search using two databases independently, including PubMed, and Web of Science. The review included prospective and retrospective studies using LITT to treat brain metastases. Results: Twenty-two original articles were analyzed in this review, particularly clinical outcomes and complications. We have also provided our institutional experience in the use of LITT to treat brain metastases and addressed future perspectives for the use of this technology. Conclusions: The current literature supports LITT as a safe and effective therapy for patients with brain metastases that have failed SRS. Larger studies are still required to better evaluate the use of systemic therapy in concomitance with LITT. New images modalities may enable optimized treatment and outcomes.

show abstract

Section: The Use Of Litt To Treat Brain Metastasesmentioning

confidence: 99%

The use of laser interstitial thermal therapy in the treatment of brain metastases: a literature review

Bastos

Fuentes

Traylor

et al. 2020

International Journal of Hyperthermia

View full text Add to dashboard Cite

show abstract

“…There are two different systems on the market, both of which provide visual representations of temperature over a certain time to induce cell death, usually 43°C for 10 min. 8 …”

Section: Principles Of Littmentioning

confidence: 99%

“… 3 Ideally the complete lesion would be covered by the thermal damage threshold (TDT) lines, although the presence of eloquent areas or heat sinks such as ventricles and blood vessels can limit lesion coverage. 8 The size of the lesion also limits ablation. Four cases of malignant cerebral edema requiring hemicraniectomy have been described after LITT, with the volumes ranging from 29 to 70 cm 3 .…”

Section: Principles Of Littmentioning

confidence: 99%

“…Furthermore, tumor size was found to be a significant predictor of PFS; patients with tumors larger than 5.62 cm 3 , the median volume of the lesions in this cohort, had a shorter PFS. 8 For metastatic brain tumors, it appears that degree of ablation is associated with significantly longer PFS. The significance of tumor size on PFS still remains in question given the limited data.…”

Section: Treatment Outcomesmentioning

confidence: 99%

See 1 more Smart Citation

Laser interstitial thermal therapy

Holste

Orringer

2019

Neuro-Oncology Advances

View full text Add to dashboard Cite

Background Laser interstitial thermal therapy (LITT) is becoming an increasingly popular technique for the treatment of brain lesions. More minimally invasive that open craniotomy for lesion resection, LITT may be more appropriate for lesions that are harder to access through an open approach, deeper lesions, and for patients who may not tolerate open surgery. Methods A search of the current primary literature on LITT for brain lesions on PubMed was performed. These studies were reviewed and updates on the radiological, pathological, and long-term outcomes after LITT for brain metastases, primary brain tumors, and radiation necrosis as well as common complications are included. Results Larger extent of ablation and LITT as frontline treatment were potential predictors of favorable progression-free and overall survival for primary brain tumors. In brain metastases, larger extent of ablation was more significantly associated with survival benefit, whereas tumor size was a possible predictor. The most common complications after LITT are transient and permanent weakness, cerebral edema, hemorrhage, seizures, and hyponatremia. Conclusions Although the current literature is limited by small sample sizes and primarily retrospective studies, LITT is a safe and effective treatment for brain lesions in the correct patient population.

show abstract

“…Laser interstitial thermal therapy (LITT) has become a frequently used treatment for CNS lesions in the past decade, with recent evidence suggesting that LITT may create local disruption of the BBB and BTB [10]. LITT is a stereotactic, minimally invasive, cytoreductive technique that can be used to create targeted and conformal thermal injury to treat a wide array of CNS lesions [11][12][13]. The technique was first described in 1983 but only recently gained traction, primarily due to technological advances, such as MRI thermometry and improved laser probe design [14,15].…”

Section: Introductionmentioning

confidence: 99%

The effect of thermal therapy on the blood-brain barrier and blood-tumor barrier

Patel

Yang

Kim

2020

International Journal of Hyperthermia

Self Cite

View full text Add to dashboard Cite

The blood-brain and blood-tumor barriers represent highly specialized structures responsible for tight regulation of molecular transit into the central nervous system. Under normal circumstances, the relative impermeability of the blood-brain barrier (BBB) protects the brain from circulating toxins and contributes to a brain microenvironment necessary for optimal neuronal function. However, in the context of tumors and other diseases of central nervous system, the BBB and the more recently appreciated blood-tumor barrier (BTB) represent barriers that prevent effective drug delivery. Overcoming both barriers to optimize treatment of central nervous system diseases remains the subject of intense scientific investigation. Although many newer technologies have been developed to overcome these barriers, thermal therapy, which dates back to the 1890 s, has been known to disrupt the BBB since at least the early 1980s. Recently, as a result of several technological advances, laser interstitial thermal therapy (LITT), a method of delivering targeted thermal therapy, has gained widespread use as a surgical technique to ablate brain tumors. In addition, accumulating evidence indicates that laser ablation may also increase local BBB/BTB permeability after treatment. We herein review the structure and function of the BBB and BTB and the impact of thermal injury, including LITT, on barrier function.

show abstract

Management of Intracranial Metastatic Disease With Laser Interstitial Thermal Therapy

Cited by 40 publications

References 22 publications

The use of laser interstitial thermal therapy in the treatment of brain metastases: a literature review

The use of laser interstitial thermal therapy in the treatment of brain metastases: a literature review

Laser interstitial thermal therapy

The effect of thermal therapy on the blood-brain barrier and blood-tumor barrier

Contact Info

Product

Resources

About