Management of intracranial haemorrhage in a newborn with inherited factor VII deficiency with the use of rFVIIa aliquots

Désage, Stéphanie; Chamouard, Valérie; Meunier, Sandrine; Enjolras, Nathalie; Sobas, Frédéric; Négrier, Claude; Quellec, Sandra Le

doi:10.1111/hae.14199

Cited by 2 publications

(1 citation statement)

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“…1 For major bleedings in patients with FVII <20 IU/dL, rFVIIa, 15-30 μg/kg, may be repeated every 4-6 h on day 1 (Grade 2B), and then every 8-12 h. At least three injections are recommended to control bleeding (Grade 2B). 26,27 FVII and rFVIIa concentrates can also considered with target FVII levels between 20 and 50 IU/dL depending on the severity and intensity of the bleeding.…”

Section: Management Of Acute Haemorrhagesmentioning

confidence: 99%

Management of rare inherited bleeding disorders: Proposals of the French Reference Centre on Haemophilia and Rare Coagulation Disorders

Trossaërt¹,

Chamouard

Biron‐Andréani

et al. 2023

European J of Haematology

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Introduction: The rare coagulation disorders may present significant difficulties in diagnosis and management. In addition, considerable inter-individual variation in bleeding phenotype is observed amongst affected individuals, making the bleeding risk difficult to assess in affected individuals. The last international recommendations on rare inherited bleeding disorders (RIBDs) were published by the United Kingdom Haemophilia Centre Doctors' Organisation in 2014. Since then, new drugs have been marketed, news studies on surgery management in patients with RIBD have been published, and new orphan diseases have been described. Aim: Therefore, the two main objectives of this review, based on the recent recommendations published by the French Reference Centre on Haemophilia and Rare Bleeding Disorders, are: (i) to briefly describe RIBD (clinical presentation and diagnostic work-up) to help physicians in patient screening for the early detection of such disorders; and (ii) to focus on the current management of acute haemorrhages and long term prophylaxis, surgical interventions, and pregnancy/delivery in patients with RIBD.

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Section: Management Of Acute Haemorrhagesmentioning

confidence: 99%