“…A common question raised with respect to performing breast-conserving therapy after neoadjuvant chemotherapy is the volume of breast tissue that should be resected. To evaluate this, Boughey et al studied [4] whether preoperative chemotherapy was able to reduce the volume of tissue excised and the number of breast operations performed and reported that in patients with T2 or T3 tumors, significantly less tissue was resected when patients received neoadjuvant chemotherapy (P < .004 for volume of tissue resected). At a median followup time of 33 months there were only two cases of ipsilateral breast recurrence, one in the neoadjuvant group, and one in the adjuvant group, leading them to conclude that it is not necessary to excise the entire pre NACT volume of tissue.…”