Management of infantile hemangiomas—experience of a tertiary hospital

Gomes, Rita; Salazar, Luís; Fraga, Carolina; Correia, Mário Rui; Barbosa-Sequeira, Joana; Fernandes, Alexandre; Álvares, Sílvia; Leitão, José Banquart; Coelho, Margarida Paiva

doi:10.1007/s00431-023-04827-2

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…Following the proliferative phase, IHs typically enter a spontaneous involution phase that starts around the first year and can last for several years (Bauland et al, 2011;Baselga et al, 2016). However, about 70% of infants experience residual effects, such as telangiectasia, excessive fibrofatty tissue, and skin laxity, and roughly 10% face complications including obstruction, functional impairment, ulceration, and disfigurement (Léauté-Labrèze et al, 2017;Gomes et al, 2023). These situations necessitate early expert consultation and intervention to prevent IHs progression.…”

Section: Introductionmentioning

confidence: 99%

Historical and contemporary management of infantile hemangiomas: a single-center experience

Zou,

Wu,

Jin

et al. 2024

Front. Pharmacol.

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Objective: This study explores the 22-year evolution of Infantile Hemangiomas (IHs) treatment strategies at a single-center hospital, aiming to establish an individualized IHs management protocol.Methods: Retrospective review of IHs infants 2000–2022 at the Department of Plastic Surgery, Jiangxi Provincial Children’s Hospital.Results: In our study of 27,513 IHs cases, 72.2% were female, with the median age at first hospital visit being 25 days. The majority of cases had localized and superficial lesions primarily on the head, face, and neck (67.5%). Ulceration rates fell from 21.1% to 12.6% with the introduction of propranolol. Management strategies have shifted over time, with the proportion of cases undergoing expectant management dropping from 32.9% to 12.4%. Since 2008, 26.1% of patients were treated with oral propranolol, largely replacing corticosteroids. Topical β-blockers have been used in 12.1% of cases, leading to a reduction in local injection therapy from 20.8% to 13.2%. Laser therapy, introduced in 2016, has been used in 13.8% of cases, while surgical excision has dropped from 25.0% to 8.5% due to alternative treatment options. Combination therapy was used in 8.8% of cases post-2015, indicating a rising trend. Drawing from the evolution of IHs management strategies, an individualized protocol for the management of IHs was successfully established.Conclusion: Treatment for IHs has evolved over recent decades, with less invasive medical interventions increasingly replacing more invasive methods. Furthermore, a personalized treatment protocol established in this study could boost the cure rate of IHs while minimizing potential side effects and complications.

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Section: Introductionmentioning

confidence: 99%

Historical and contemporary management of infantile hemangiomas: a single-center experience

Zou,

Wu,

Jin

et al. 2024

Front. Pharmacol.

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Clinical and morphological characteristics and diagnosis of external haemangiomas in children

Toktosunova,

Toktosunov,

Sharshenov

2023

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Background. The relevance lies in the increasing occurrence of haemangiomas in children under 1 year old when diagnosis confirmation through morphological methods is necessary. The purpose of the research is to characterise the histological initial and final changes of cutaneous haemangiomas and to present the main clinical manifestations of haemangiomas in children. Materials and methods. Several clinical (for detailed diagnosis of the disease), morphological (histological examination of the material) and statistical methods were used in the work. The object of the research was 98 children with haemangiomas of the facial skin aged 6 months to 16 years. Results. The morphological study demonstrated that in 49 cases (50 %), the typical simple capillary structure of haemangioma was identified, in 35 cases (35.7 %) — cavernous type of neoplasm. Only 18.3 % of the children had combined haemangiomas. Capillary-type haemangiomas contain many small capillaries with a narrow lumen, covered by adhering fleshy epithelium. Conclusions. During the phase of the active growth of haemangiomas, there is a predominance of massive endothelial cells, suggesting that the vascular component, particularly proliferating epithelium-lined capillaries, makes up the main and largest part of the hyperplasia.

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Management of infantile hemangiomas—experience of a tertiary hospital

Cited by 2 publications

References 41 publications

Historical and contemporary management of infantile hemangiomas: a single-center experience

Historical and contemporary management of infantile hemangiomas: a single-center experience

Clinical and morphological characteristics and diagnosis of external haemangiomas in children

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