Management of Hyperuricemia and Gout in CKD

Gaffo, Angelo L.; Saag, Kenneth G.

doi:10.1053/j.ajkd.2008.07.035

Cited by 25 publications

(45 citation statements)

References 121 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the patients who initially had a serum uric acid level of between 7.0 mg/dL and 8.9 mg/dL, the annual incidence rate decreased to 0.5%, and this decreased further to 0.1% in patients who had an original serum uric acid level of below 7.0 mg/dL. 7 This clearly indicates how important hyperuricaemia is as a risk factor for the development of gout. 7 Furthermore, the Rochester Epidemiology Project has revealed that the incidence of gout increased from 45/100 000 between 1977 and 1978 to 63.2/100 000 in the period between 1995 and 1996.…”

Section: Incidence Of Gout In Various Populationsmentioning

confidence: 87%

“…7 This clearly indicates how important hyperuricaemia is as a risk factor for the development of gout. 7 Furthermore, the Rochester Epidemiology Project has revealed that the incidence of gout increased from 45/100 000 between 1977 and 1978 to 63.2/100 000 in the period between 1995 and 1996. 7 Prevalence A 4.1% prevalence of hyperuricaemia was found in a previous study in people older than 75 years.…”

Section: Incidence Of Gout In Various Populationsmentioning

confidence: 97%

“…7 Furthermore, the Rochester Epidemiology Project has revealed that the incidence of gout increased from 45/100 000 between 1977 and 1978 to 63.2/100 000 in the period between 1995 and 1996. 7 Prevalence A 4.1% prevalence of hyperuricaemia was found in a previous study in people older than 75 years. 2 However, care should be taken when comparing prevalence rates of gout in different studies, as there are so many variables to take into consideration.…”

Section: Incidence Of Gout In Various Populationsmentioning

confidence: 99%

“…This causes the body fluids to become supersaturated with uric acid, which means a level of 6.8 mg/dL. 7 In men and postmenopausal women, hyperuricaemia is defined as a serum uric acid level of greater than 7.0 mg/dL. In premenopausal women, hyperuricaemia is characterised by a serum uric acid level that is greater than 6.0 mg/dL.…”

Section: Pathophysiologymentioning

confidence: 99%

“…9 The symptoms of an acute gout attack tend to be most pronounced eight to twelve hours after the start of the attack. 7 The monosodium urate crystals that gather in hyperuricaemic patients activate both the humoral and cellular components of the immune system. These crystals stimulate the recruitment and consequent adhesion of neutrophils, leading to inflammation.…”

Section: Asymptomatic Hyperuricaemiamentioning

confidence: 99%

See 4 more Smart Citations

Hyperuricaemia and gout: A review

Kopke

Greeff

2010

South African Family Practice

View full text Add to dashboard Cite

Gout is a painful, inflammatory disease that affects more men than women. The incidence of gout has increased substantially over the past few decades, as evidenced by information from the Rochester project. Some of the risk factors for the development of gout include: increased ethanol intake, high dietary purine consumption, obesity and the use of certain drugs, such as diuretics. Another important risk factor for the development of gout is hyperuricaemia.Hyperuricaemia results from an imbalance between the rate of production and excretion of uric acid in the body. An excess of uric acid thus builds up in the body, supersaturating body fluids and leading to the formation of monosodium urate crystals. These crystals accumulate in tissue and around joints, leading to an acute gout attack.Gout can be divided into four phases, namely asymptomatic hyperuricaemia, acute gout attacks or recurrent gout, intercritical gout and chronic tophaceous gout. Various treatment options are available for gout, and the treatment for each gout patient is determined by the stage of the disease. Non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, corticotropin and colchicine are used for the treatment of acute gout attacks. Allopurinol and probenecid are used for long-term hypouricaemic therapy, while NSAIDs and colchicine are prescribed for the prophylaxis of future gout attacks.All of these treatments have side effects, ranging from mild to life-threatening in nature. There is a need for novel gout therapies that have fewer side effects but are still as effective.Peer reviewed.

show abstract

Section: Incidence Of Gout In Various Populationsmentioning

confidence: 87%

Section: Incidence Of Gout In Various Populationsmentioning

confidence: 97%

Section: Incidence Of Gout In Various Populationsmentioning

confidence: 99%

Section: Pathophysiologymentioning

confidence: 99%

Section: Asymptomatic Hyperuricaemiamentioning

confidence: 99%

See 3 more Smart Citations

Hyperuricaemia and gout: A review

Kopke

Greeff

2010

South African Family Practice

View full text Add to dashboard Cite

show abstract

My Treatment Approach to Gout

Aslam

Michet

2017

Mayo Clinic Proceedings

View full text Add to dashboard Cite

Gout is the most common form of inflammatory arthritis in the United States. Nevertheless, gout remains misunderstood, misdiagnosed, underdiagnosed, and undertreated. Several new recommendation and guideline documents regarding the management of gout have been published in the past few years. New diagnostic modalities, such as ultrasound and dual-energy computed tomography, are now available. Newer treatment options exist, and older agents and their interactions are now better understood. This review addresses these recent diagnostic and therapeutic developments and describes our management protocol with the aim of providing the clinician with a pragmatic approach to gout management.

show abstract