Management of Hypertension with Female Sexual Dysfunction

Zhong, Qing; Anderson, Yuri Kamihagi

doi:10.3390/medicina58050637

Cited by 7 publications

(12 citation statements)

References 40 publications

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“…The main symptoms of female sexual dysfunction include pain during sexual intercourse or unpleasurable sex, lack of orgasm, low sexual desire, lack of arousal or decreased libido, and difficulty with vaginal lubrication. 16 , 24 , 27 Moreover, although it has been established that hypertension is associated with sexual dysfunction in men, this phenomenon has been poorly studied in women. However, the few available studies indicate that women with hypertension also experience sexual dysfunction, affecting all domains, such as sexual desire, arousal, lubrication, orgasm, satisfaction, and pain.…”

Section: Resultsmentioning

confidence: 99%

“…High blood pressure can worsen fibrosis in female genital tissue and cause damage to endothelial cells due to oxidation and inflammation related to hypertension. 11 , 27 …”

Section: Resultsmentioning

confidence: 99%

“…Blood pressure control is key when treating female sexual dysfunction in the presence of hypertension, and the administration of angiotensin receptor blockers is preferred. 27 …”

Section: Resultsmentioning

confidence: 99%

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Relationship Between Hypertension, Antihypertensive Drugs and Sexual Dysfunction in Men and Women: A Literature Review

Lou,

Chen,

Ali

et al. 2023

VHRM

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Sexual dysfunction pertains to any issue that hinders an individual from attaining sexual contentment. This health issue can have a significant impact on the quality of life and psychological health of affected individuals. Sexual dysfunction can generate stress, anxiety, depression, and low self-esteem, which can lead to a reduction in overall life satisfaction and the quality of interpersonal relationships. Sexual dysfunction can manifest as erectile dysfunction in men or lack of sexual desire in women. Although both sexes can experience sexual problems, there are some significant differences in the manifestation of sexual dysfunction between men and women. In men, sexual dysfunction is usually physical and associated with problems such as erectile dysfunction, while in women, sexual dysfunction is usually related to psychological factors. Additionally, there was an association between hypertension and sexual dysfunction in both the sexes. In men, hypertension can cause erection problems, whereas in women, it can cause vaginal dryness and a decrease in sexual desire. Furthermore, antihypertensive drugs can negatively impact sexual function, which can decrease adherence to drug treatment. However, nebivolol, an antihypertensive drug, has beneficial effects on erectile dysfunction in men. This is believed to be because nebivolol improves blood flow to the penis by producing nitric oxide, which can help improve erections.

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Section: Resultsmentioning

confidence: 99%

“…High blood pressure can worsen fibrosis in female genital tissue and cause damage to endothelial cells due to oxidation and inflammation related to hypertension. 11 , 27 …”

Section: Resultsmentioning

confidence: 99%

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Relationship Between Hypertension, Antihypertensive Drugs and Sexual Dysfunction in Men and Women: A Literature Review

Lou,

Chen,

Ali

et al. 2023

VHRM

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“…Furthermore, some, 12 but not all, 13 studies have suggested that FSD improves with antihypertensive treatment. In contrast, however, beta‐blockers have been shown to worsen sexual function in women 14 …”

Section: Introductionmentioning

confidence: 99%

“…In contrast, however, beta-blockers have been shown to worsen sexual function in women. 14 Only a few studies have examined the relationship between atherosclerosis and FSD. Atherosclerosis is a lipid-driven chronic inflammatory process that leads to plaque build-up inside arteries, reducing arterial blood flow.…”

Section: Introductionmentioning

confidence: 99%

Associations between arterial health and sexual function in women aged 60–64 years

Virkkunen,

Kero,

Koivisto

et al. 2024

Acta Obstet Gynecol Scand

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IntroductionFemale sexual dysfunction is very common, but its determinants remain under‐investigated. Vasculogenic impairments are suggested to be related to female sexual dysfunction, but previous literature regarding the association is scarce. This study aims to study the association between arterial health and female sexual function in women in their 60s.Material and methodsThe sample for this cross‐sectional study comprised 117 women (aged 60–64 years) who participated in the Finnish Retirement and Aging study. Arterial health was measured according to the participants' pulse wave velocity, ankle–brachial index, blood pressure, and pulse pressure. Sexual function was measured using the Female Sexual Function Index, which resulted in a total score and six sub‐scores. Associations were examined using multivariable regression analyses, which were adjusted for age, relationship happiness, systemic menopausal hormone therapy and/or local estrogen, smoking, alcohol risk use, body mass index, and depressive symptoms.ResultsHigher diastolic blood pressure was associated with a higher total Female Sexual Function Index score (β = 0.24, 95% confidence interval [CI] 0.07–0.41) and with higher desire (β = 0.02, 95% CI 0.01–0.04), arousal (β = 0.04, 95% CI 0.01–0.08), lubrication (β = 0.04, 95% CI 0.002–0.08), satisfaction (β = 0.03, 95% CI 0.003–0.05), and pain (β = 0.06, 95% CI 0.02–0.10) sub‐scores. Also, higher ankle–brachial index was associated with higher satisfaction sub‐score (β = 2.10, 95% CI 0.44–3.73) and lower pulse pressure was associated with higher orgasm sub‐score (β = 0.03, 95% CI 0.0002–0.06). Other associations between ankle–brachial index and Female Sexual Function Index scores were statistically insignificant, but considering the magnitude the findings may imply clinical significance. Systolic blood pressure and pulse wave velocity were not associated with sexual function.ConclusionsThis study suggested a plausible association between higher diastolic blood pressure and female sexual function, but considering clinical significance our findings suggest an association between higher ankle–brachial index and good sexual function in women in their 60s.

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Association between cardiovascular disease and risk of female sexual dysfunction: a systematic review and meta-analysis

Dilixiati,

Cao,

Mao

et al. 2024

European Journal of Preventive Cardiology

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Aim Female sexual dysfunction (FSD) is a considerably underestimated condition. It has been repeatedly reported that patients with cardiovascular diseases (CVD) may suffer from an increased risk of FSD. However, there is still a lack of comprehensive and systematic evaluation of various CVD and FSD. We aimed to elucidate the association between CVD and FSD through a comprehensive literature review and meta-analysis. Methods and result The PubMed, Scopus, Embase, and Cochrane Library databases were systematically searched from inception to February 28, 2023. We identified all relevant studies reporting the risk of FSD in subjects with or without CVD. The associations between CVD and the risk of FSD were assessed by calculating pooled ORs (cross-sectional studies) and RRs (longitudinal studies) with 95% CIs. We employed random-effects models to account for potential heterogeneity, and the quality of the included studies was assessed using the Newcastle-Ottawa Scale (NOS). Fifty-four articles with 148,946 individuals were included in our meta-analysis. Compared with control subjects, subjects with CVD had a 1.51-fold increased risk of FSD (OR 1.51 95% CI, 1.34-1.69, P < .001, heterogeneity I2 = 91.4%, P < .001). Subgroup analyses indicated that the association between CVD and FSD remained significant in longitudinal studies (RR 1.50 95% CI, 1.21-1.86, P < .001, heterogeneity I2 = 86.7%, P < .001). Particularly, hypertension (OR 1.41 95% CI, 1.23-1.62, P < .001, heterogeneity I2 = 82.7%, P < .001), stroke (OR 1.81 95% CI, 1.54-2.12, P < .001, heterogeneity I2 = 0%, P < .423), and myocardial infarction (OR 2.07 95% CI, 1.60-2.67, P < .001 heterogeneity I2 = 82.4%, P < .001) were significantly associated with FSD. Meta-regression revealed that the primary sources of heterogeneity in FSD are attributable to adjustments for covariates, study design, and study population. Conclusion Our meta-analysis indicated that patients with CVD suffer from a greater risk of developing FSD. Meanwhile, we validated these findings in longitudinal queues. Notably, conditions such as hypertension, stroke, and myocardial infarction demonstrated a significant association with the incidence of FSD.

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Management of Hypertension with Female Sexual Dysfunction

Cited by 7 publications

References 40 publications

Relationship Between Hypertension, Antihypertensive Drugs and Sexual Dysfunction in Men and Women: A Literature Review

Relationship Between Hypertension, Antihypertensive Drugs and Sexual Dysfunction in Men and Women: A Literature Review

Associations between arterial health and sexual function in women aged 60–64 years

Association between cardiovascular disease and risk of female sexual dysfunction: a systematic review and meta-analysis

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