Management of hyperlipidemias: An update

Ranjan, Nitin

doi:10.4103/0378-6323.55387

Cited by 7 publications

(5 citation statements)

References 57 publications

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“…This change could be considered beneficial in relation to its effect on cardiovascular disease (Blaha et al . 2008; Ranjan 2009).…”

Section: Resultsmentioning

confidence: 99%

“…Table 4 indicates the effect of the diets given to the different study groups, showing a significant decrease in LDLcholesterol concentration of diet 4 group and a slight but definite increase in HDL-cholesterol concentration. This change could be considered beneficial in relation to its effect on cardiovascular disease (Blaha et al 2008;Ranjan 2009).…”

Section: Biological Evaluationmentioning

confidence: 99%

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EVALUATION OF THE NUTRITIONAL QUALITY OF NONTOXIC KERNEL FLOUR FROM JATROPHA CURCAS L. IN RATS

Herrera

Jiménez‐Martínez²,

Ayala

et al. 2012

Journal of Food Quality

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The origin of Jatropha curcas L. is in Central America, probably Mexico, although it is also distributed in South America, Africa and Asia. In Mexico, it grows as nontoxic and toxic J. curcas genotypes. In this work, the protein quality including protein efficiency ratio (PER), net protein ratio (NPR) and true digestibility (TD) of nontoxic genotype defatted flour was assessed using Wistar rats. The probed diets contained flour (3), flour‐lysine, 1% (4), flour‐phytase, 500 FTU (5) and two control diets: nitrogen‐free (1) and casein (2). The rats were fed for 28 days. The PER (1.37, 1.77 and 1.61) and NPR (1.80, 2.29 and 2.12) obtained values for diets (3.4 and 5) were lower than those obtained for casein (2.07 and 2.46), respectively. No statistical differences were found in TD. PRACTICAL APPLICATIONS Jatropha curcas defatted flour may be used in the food industry for the development of diets for human and animal consumption. Besides achieving fortification of foods that are made from wheat, which has a low protein content, with the addition of Jatropha meal, these foods will improve the protein quality of many food products.

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“…This change could be considered beneficial in relation to its effect on cardiovascular disease (Blaha et al . 2008; Ranjan 2009).…”

Section: Resultsmentioning

confidence: 99%

Section: Biological Evaluationmentioning

confidence: 99%

EVALUATION OF THE NUTRITIONAL QUALITY OF NONTOXIC KERNEL FLOUR FROM JATROPHA CURCAS L. IN RATS

Herrera

Jiménez‐Martínez²,

Ayala

et al. 2012

Journal of Food Quality

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“…Ezetimibe reduces cholesterol by blocking the uptake of cholesterol into jejunal enterocytes. [ 2 ] STs are drugs of first choice for the patients with hypercholesterolemia, especially in those at high cardiovascular risk, however some of these patients are intolerant to STs. [ 3 ] Dietary ingredients include vitamins, minerals, amino acids, and herbs or botanicals, as well as other substances that can be used to supplement the diet.…”

Section: Introductionmentioning

confidence: 99%

Cholesterol esterase inhibitory activity of bioactives from leaves of Mangifera indica L

Gururaja

Mundkinajeddu²,

Dethe³

et al. 2015

Phcog Res

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Background:In the earlier studies, methanolic extract of Mangifera indica L leaf was exhibited hypocholesterol activity. However, the bioactive compounds responsible for the same are not reported so far.Objective:To isolate the bioactive compounds with hypocholesterol activity from the leaf extract using cholesterol esterase inhibition assay which can be used for the standardization of extract.Materials and Methods:The leaf methanolic extract of M. indica (Sindoora variety) was partitioned with ethyl acetate and chromatographed on silica gel to yield twelve fractions and the activity was monitored by using cholesterol esterase inhibition assay. Active fractions were re-chromatographed to yield individual compounds.Results and Discussion:A major compound mangiferin present in the extract was screened along with other varieties of mango leaves for cholesterol esterase inhibition assay. However, the result indicates that compounds other than mangiferin may be active in the extract. Invitro pancreatic cholesterol esterase inhibition assay was used for bioactivity guided fractionation (BAGF) to yield bioactive compound for standardization of extract. Bioactivity guided fractionation afford the active fraction containing 3b-taraxerol with an IC50 value of 0.86μg/ml.Conclusion:This study demonstrates that M. indica methanol extract of leaf have significant hypocholesterol activity which is standardized with 3b-taraxerol, a standardized extract for hypocholesterol activity resulted in development of dietary supplement from leaves of Mangifera indica.

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“…Cholesterol, a greasy substance, the main constituent of steroid hormones, bile salts and vitamin D. It is a constituent of cell membranes as well. It is both derived from the diet and synthesized within the body, specifically in the liver [7]. Raised serum cholesterol level predisposes to the risk of heart disease and stroke.…”

Section: Introductionmentioning

confidence: 99%

Evaluation Hypolipidemic Activity of Arogyavardhini and Zpter Tablet in Cholesterol-Rich High Fat Diet (Hfd) Induced Hyperlipidemia in Wistar Rats

Ghadigaonkar¹,

Chawda²,

Thakur³

et al. 2019

Int J Pharm Pharm Sci

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Objective:The present research work aims to evaluate the hypolipidemic activity of arogyavardhini and zpter tablet in high fat diet (HFD) induced hyperlipidemia in wistar rats. Methods:Wistar rats were divided in 5 groups. The normal control group received standard pellet diet. The HFD group received HFD rich in cholesterol. The HFD+Arogyavardhini group received HFD rich in cholesterol along with Arogyavardhini treatment. The HFD+zpter group received HFD rich in cholesterol along with zpter treatment. The standard Control group received HFD rich in cholesterol and treatment with Atorvastatin. Serum Lipid profile estimation and histopathological estimations done at end treatment. Group means were compared with Analysis of Variance (ANOVA) followed by Tukey's post-hoc analysis (P<0.05).Result: HFD group shows significant (P<0.05) increase in total cholesterol (TC) levels (207.15 mg/dl) and triglyceride (TG) levels (223.83 mg/dl) when compared with standard pellet fed rats (TC=151.05 mg/dl and TG=164.67 mg/dl). Treatment with Arogyavardhini significantly (P<0.05) reduces the increased levels of TC (160.123 mg/dl) and TG (189.5 mg/dl) in hyperlipedimic rats. Treatment with Zpter significantly (P<0.05) reduces the increased levels of TC (163.89 mg/dl) and TG (193.167 mg/dl) in hyperlipedimic rats, which is comparable to standard treatment atorvastatin (TC= 155.81 mg/dl, TG=180.33 mg/dl). Conclusion:The observations in this study suggest that, herbal formulations arogyavardhini and zpter have the potential to overcome hyperlipidemia.

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Management of hyperlipidemias: An update

Cited by 7 publications

References 57 publications

EVALUATION OF THE NUTRITIONAL QUALITY OF NONTOXIC KERNEL FLOUR FROM JATROPHA CURCAS L. IN RATS

EVALUATION OF THE NUTRITIONAL QUALITY OF NONTOXIC KERNEL FLOUR FROM JATROPHA CURCAS L. IN RATS

Cholesterol esterase inhibitory activity of bioactives from leaves of Mangifera indica L

Evaluation Hypolipidemic Activity of Arogyavardhini and Zpter Tablet in Cholesterol-Rich High Fat Diet (Hfd) Induced Hyperlipidemia in Wistar Rats

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