2022
DOI: 10.1007/s00125-022-05787-2
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Management of hyperglycaemia in type 2 diabetes, 2022. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Abstract: The American Diabetes Association and the European Association for the Study of Diabetes convened a panel to update the previous consensus statements on the management of hyperglycaemia in type 2 diabetes in adults, published since 2006 and last updated in 2019. The target audience is the full spectrum of the professional healthcare team providing diabetes care in the USA and Europe. A systematic examination of publications since 2018 informed new recommendations. These include additional focus on social deter… Show more

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Cited by 361 publications
(340 citation statements)
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References 334 publications
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“…This is interesting, as there appears to be an increasing focus on treating excess weight in the management of type 2 diabetes, both for remission 53 and potentially reduction in multiple complications 54 . This focus on a need to target excess weight more in type 2 diabetes has also been recognized in the recently updated ADA/EASD recommendations 55 . The work summarized also provide more evidence for a multifactorial approach (targeting not only glycaemia but also blood pressure, excess weight and lipids) to treating type 2 diabetes to prevent complications.…”
Section: Discussionmentioning
confidence: 97%
“…This is interesting, as there appears to be an increasing focus on treating excess weight in the management of type 2 diabetes, both for remission 53 and potentially reduction in multiple complications 54 . This focus on a need to target excess weight more in type 2 diabetes has also been recognized in the recently updated ADA/EASD recommendations 55 . The work summarized also provide more evidence for a multifactorial approach (targeting not only glycaemia but also blood pressure, excess weight and lipids) to treating type 2 diabetes to prevent complications.…”
Section: Discussionmentioning
confidence: 97%
“…Numerous CV trials have reported improvements in CV outcomes in patients treated with GLP-1 RAs. 49,50 GLP-1 has pleiotropic CV effects, including anti-inflammatory effects, cardioprotection in ischemia, and decreased platelet aggregation. 38 In addition, activation of GLP-1R resulted in various anti-atherosclerotic effects, e.g., reversing endothelial dysfunction (stimulates nitric oxide [NO] production and endothelial NO synthase [eNOS] activation, eliciting vasorelaxation in arterial endothelium), improving vascular smooth muscle cell dysfunction, reducing macrophage inflammation and foam cell formation, inhibiting NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) inflammasome and improving cardiomyocyte/cardiac fibroblast dysfunction.…”
Section: Pathophysiology Of Glp-1 Receptor (Glp-1r) Agonism In Cardio...mentioning
confidence: 99%
“…В соответствии с консенсусом Европейской ассоциации по изучению диабета (European Association for the Study of Diabetes, EASD) и Американской диабетологической ассоциации (American Diabetes Association, ADA) 2022 г. пиоглитазон в качестве сахароснижающего препарата в лечении СД2 находится в числе приоритетных у лиц с наличием или высоким риском ассоциированных СС-заболеваний, а также у пациентов, не страдающих СС-заболеваниями, с позиции высокой эффективности гликемического контроля (рис. 2) [67].…”
Section: пиоглитазон атеросклероз и сердечно-сосудистые заболеванияunclassified