Management of Human Ulcerative Colitis by SaturexTM: A Randomized Controlled Trial

Rastegarpa, Mansoor; Omidzohour, Nagluneh; Vahedi, Homayoon; Malekzadeh, Reza; Hashemian, Farnaz; Safarnavad, Tahereh; Abdollahi, Mohammad

doi:10.3923/ijp.2011.516.521

Cited by 12 publications

(3 citation statements)

References 29 publications

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“…Therefore, we focused our attention onto the existing studies on humans (250-500 mg/individual/day) and various other animal species. These included rabbits (250 mg/kg/day), rats (500-5000 mg/kg/day), and broiler chicks (100-400 mg/kg/day) [32,[62][63][64][65][66]. In the present study, the elected dose of S. hortensis powders was 100 mg/kg bw/day, administered under the same protocol as for marigold.…”

Section: Discussionmentioning

confidence: 99%

Satureja hortensis L. and Calendula officinalis L., Two Romanian Plants, with In Vivo Antiparasitic Potential against Digestive Parasites of Swine

Băieş,

Cotuţiu,

Spînu

et al. 2023

Microorganisms

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Internal parasitic diseases of swine constitute a major welfare and health concern in low-input livestock farming. Due to an increase in chemical resistance, phytotherapeutic remedies have become an alternative for the prophylaxis and therapy of digestive parasitosis, albeit few remedies have been subjected to scientific validation. Low-input swine farming in Romania has adopted the traditional use of phytotherapy for controlling pathogens in livestock. The current study aimed to assess the antiparasitic potential of Calendula officinalis and Satureja hortensis against digestive parasites of swine in two low-input farms. The fecal samples were collected from sows, fatteners, and weaners, and were tested using the following coproparasitological methods: centrifugal sedimentation, flotation (Willis, McMaster egg counting technique), Ziehl–Neelsen stain modified by Henricksen, modified Blagg method, and in vitro nematode larvae/protozoan oocyst cultures. Six species of digestive parasites were diagnosed, namely Ascaris suum, Trichuris suis, Oesophagostomum spp., Balantioides coli, Eimeria spp., and Cryptosporidium spp., in various combinations, dependent on the swine category. A dose of 140 mg/kg bw/day of C. officinalis and 100 mg/kg bw/day of S. hortensis powders administered for 10 consecutive days revealed a strong antiprotozoal and anthelmintic activity on the aforementioned parasites. The curative efficacy can be attributed to the presence of polyphenols, sterols, tocopherols, and methoxylated flavones. In conclusion, our results indicate that S. hortensis and C. officinalis are promising alternatives to the commercially available antiparasitics, enabling their use as natural antiparasitic products against gastrointestinal parasites in pigs.

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Section: Discussionmentioning

confidence: 99%

Satureja hortensis L. and Calendula officinalis L., Two Romanian Plants, with In Vivo Antiparasitic Potential against Digestive Parasites of Swine

Băieş,

Cotuţiu,

Spînu

et al. 2023

Microorganisms

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“…Additionally, both macroscopical and histological signs of colon inflammation were decreased in animals administered with Summer Savory extract compared to colitis animals. Surprisingly, even though no preclinical animal study was published until now that evaluated the beneficial effects of Summer Savory in experimental IBD, there is one publication reporting the results of a small clinical trial studying the administration of a commercial preparation of Summer Savory in Ulcerative Colitis patients [53]. This trial was a randomized, double-blind, placebo-controlled study that assessed the clinical benefit of commercial tablets of dried leaves of Summer Savory (500 mg daily) in Ulcerative Colitis.…”

Section: Discussionmentioning

confidence: 99%

Attenuation of Colonic Injury and Inflammation by Administration of a Phenolic Extract of Summer Savory (Satureja hortensis L.) in Experimental Inflammatory Bowel Disease in Mice

et al. 2020

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Summer Savory (Satureja hortensis L.) is a plant traditionally used as a food spice in the Mediterranean region. Surprisingly, not much is known about the health beneficial effects of its phenolic-rich extracts. The majority of publications have always focused on the properties of their essential oil. One of the main phenolic compounds of Summer Savory is rosmarinic acid, which has demonstrated anti-inflammatory outcomes in several animal models of inflammatory-mediated diseases. Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease, in addition to Ulcerative Colitis and Crohn’s Disease, frequently related with increased morbidity and even mortality due to the complications associated, including colorectal cancer. Our work has shown, to our knowledge, for the first time, that administration of a phenolic extract of Summer Savory in a mouse model of Ulcerative Colitis led to the reduction of several markers for intestinal injury, including reduction of inducible nitric oxide synthase (iNOS) and Cyclooxygenase-2 (COX-2 or prostaglandin-endoperoxide synthase) expression, two well-known mediators of tissue inflammation and progression to cancer and led also to a reduction of the mortality. Given the chemical constitution found in the extract and the preclinical evidence of a beneficial effect of polyphenols in inflammatory processes, an opportunity arises for pharmacological modulation of pathways relevant for IBD and progression to cancer with phenolic-rich extracts.

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“…Recently a broad range of biological activities of S. khuzestanica extracts and essential oil were investigated, and found to have antibacterial (Seghatoleslami et al, 2009; Shahab et al, 2011; Hadian et al, 2012; Motaharinia et al, 2012), antifungal (Sadeghi-Nejad et al, 2010; Zarrin et al, 2010), anti-parasitic (Kheirandish et al, 2011; Sadeghi-Nejad et al, 2011; Zibaei et al, 2012), antioxidant (Abdollahi et al, 2003; Rezvanfar et al, 2008, 2010; Ahmadvand et al, 2012; Hashemi et al, 2012; Saei-Dehkordi et al, 2012), anti-diabetic (Abdollahi et al, 2003; Saadat et al, 2004; Nazari et al, 2005; Basiri et al, 2007; Vosough-Ghanbari et al, 2008; Shahsavari et al, 2009; Tavafi et al, 2011; Kaeidi et al, 2013), anti-inflammatory (Amanlou et al, 2005; Ghazanfari et al, 2006; Rezvanfar et al, 2010; Rastegarpanah et al, 2011; Shahab et al, 2011), anti-coagulant, and antihyperlipidemic (Nazari et al, 2005) properties. Carvacrol was identified as the main constituent of the essential oil (Sefidkon & Ahmadi, 2000; Farsam et al, 2004; Hadian et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Characterization ofSatureja khuzestanicaLeaf as a Herbal Medicine

et al. 2014

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Dried leaves of Satureja khuzestanica Jamzad are a popular herbal medicine and dental anesthetic among the nomadic inhabitants of southwestern Iran. The present study establishes criteria for identification of S. khuzestanica dried whole, fragmented and powdered leaves for specification as a herbal substance using macroscopic and microscopic characterization. Quantitative microscopy techniques were also considered. Macroscopically leaves exhibit a grayish-green color, are broadly ovate in shape with an acute apex, attenuate base, and ciliate margin and have a surface covered by an indumentum of glandular and non-glandular trichomes. Microscopically leaves have an isobilateral amphistomatic structure containing peltate glandular trichomes consisting of a multiseriate stalk (five cells) and an enlarged secretory head composed of 12 cells, capitate glandular trichomes of variable morphology together with two types of non-glandular trichomes. Oval-shaped hygromorphic diacytic stomata with an adaxial stomatal index of 13.54, collateral vascular bundles consisting of xylem, and three layers of sclerenchymatous tissue close to phloem together with cluster, prismatic and raphide calcium oxalate crystals were also identified as useful pharmacognostic parameters for identification of S. khuzestanica dried leaves.

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Management of Human Ulcerative Colitis by SaturexTM: A Randomized Controlled Trial

Cited by 12 publications

References 29 publications

Satureja hortensis L. and Calendula officinalis L., Two Romanian Plants, with In Vivo Antiparasitic Potential against Digestive Parasites of Swine

Satureja hortensis L. and Calendula officinalis L., Two Romanian Plants, with In Vivo Antiparasitic Potential against Digestive Parasites of Swine

Attenuation of Colonic Injury and Inflammation by Administration of a Phenolic Extract of Summer Savory (Satureja hortensis L.) in Experimental Inflammatory Bowel Disease in Mice

Characterization ofSatureja khuzestanicaLeaf as a Herbal Medicine

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