Management of High‐Grade Intraepithelial Neoplasia in Barrett's Esophagus

Bergman, Jacques J.G.H.M.; Fockens, Paul

doi:10.1002/9780470987513.ch25

Cited by 2 publications

(2 citation statements)

References 55 publications

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“…8 All of these methods ablate tissue without the benefit of histological specimen retrieval. [9][10][11][12][13] Their aim is to destroy the metaplastic/ dysplastic epithelium, which will then be replaced, in non-acid environments, by squamous epithelium. 14 The interest in ablation techniques was revived by the development of radiofrequency ablation (RFA) devices.…”

Section: Introductionmentioning

confidence: 99%

Sixteen‐year follow‐up of Barrett's esophagus, endoscopically treated with argon plasma coagulation

et al. 2014

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Objective: The thermal destruction of non-dysplastic Barrett's esophagus (BE) and its replacement by squamous epithelium is an attractive, but unproven strategy to avoid further development of dysplasia or cancer. The goal of this study was to estimate the persistence of restoration of squamous epithelium and the risk of cancer in BE that was eradicated using argon plasma coagulation (APC) in the absence of high-grade dysplasia, 16 years after its application. Design: We followed 32 patients with BE who underwent eradication of metaplastic epithelium using APC, up to 16 years later. Results: At the end of the initial treatment, 25 of 32 patients (78%) had complete endoscopic eradication, there was partial squamous re-epithelialization in four patients (13%) and it was absent in three patients (9%). We observed buried metaplastic glands under new squamous epithelium in 6 of the 25 patients who had complete endoscopic eradication. At followup, sustained complete endoscopic eradication was observed in 16 of 32 patients (50%), partial eradication in 11 of 32 patients (35%); there were two patients (6%) lost to follow-up and three patients (9%) developed esophageal adenocarcinoma. Two of the latest cases arose from the buried glands under neosquamous epithelium after complete eradication and one arose from a small remaining Barrett's segment. Conclusions: We observed long-term re-epithelialization in the majority of patients who had previously had complete eradication of Barrett's esophagus. This did not provide protection against cancer development, as the incidence of cancers arising from buried glands or from residual Barrett's esophagus was similar to that observed in patients undergoing no specific treatment.

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Section: Introductionmentioning

confidence: 99%

Sixteen‐year follow‐up of Barrett's esophagus, endoscopically treated with argon plasma coagulation

et al. 2014

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“…It has been suggested that patients with HGD should have a thorough work-up in a tertiary referral centre that see high volume cases with multi-disciplinary expertise. 22 In patients who are unfit or decline surgical treatment, endoscopic mucosal resection or ablation should be considered. Some patients may opt for a wait and watch policy and defer any intervention until definite cancer is detected.…”

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confidence: 99%