Management of grade III giant cell tumors of bones

Abstract

Our results suggest that surgical curettage with various adjuvant modalities might be considered as the first choice for treatment of high-grade GCTs in weight-bearing areas, especially in young patients, to avoid unnecessary endoprosthesis.

Clinical Outcomes of Grade 3 Giant Cell Tumor of Bone After Extended Intralesional Curettage

“…Though, it has not reported clinically significant differences in both groups [24]. The average MSTS score at last follow-up was 84-93% [23]. In our study, it was 89.36%.…”

Which Treatment is the Best for Giant Cell Tumors of the Distal Radius? A Meta-analysis

“…Extension of curettage has been achieved using a highspeed burr combined with adjuvant to preserve joint function, and this method has been associated with a low rate of recurrence (4%-14%) [5,6,12,13,23,25,27,36,44,48,52,53,56]. Therefore, our objective was to identify cases of GCTs of the distal radius to determine whether curettage is associated with lower rates of recurrences and fewer major complications compared with en bloc excision, and whether recurrence rates differed with the use of PMMA versus bone graft in patients treated with curettage.…”

Treating Giant Cell Tumours with Curettage, Electrocautery, Burring, Phenol Irrigation, and Cementation

“…About 2 to 10% of patients developed distant metastasis, usually in the lung. 5 The local recurrence rate is high after conservative treatment. The rate decreases to <10% after curettage and adjuvant treatments.…”

“…Methotrexate-loaded bone cement (rather than simple cement) minimises the amount of tumour-induced osteolysis and is useful for treating pathologic fractures. 5 The histological grade of tumour has little value in predicting treatment outcome. 8,11 The rate of local recurrence correlates more with the treatment method.…”

“…High-dose (>40 G) radiation therapy is effective, but about 2% of radiated GCTs become malignant. 4,5 Treatment options depend on the stage and location of the tumour and the age of the patient. Radical surgery is recommended, as local recurrence is common after conservative surgery (such as simple curettage and bone grafting).…”