Management of fluorescent organic/inorganic nanohybrids for biomedical applications in the NIR-II region

Li, Benhao; Zhao, Mengyao; Lin, Jing; Huang, Peng; Chen, Xiaoyuan

doi:10.1039/d2cs00131d

Cited by 62 publications

(34 citation statements)

References 111 publications

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“…The positrons emitted by the accumulated radionuclides in living subjects are annihilated and detected [ 196 ]. PET scanners detect isotopes in deep tissues at picomolar concentrations [ 197 ]. This unique sensitivity can be used to obtain quantitative information from drugs that have accumulated at target sites [ 198 ].…”

Section: Nanozymes For Molecular Imagingmentioning

confidence: 99%

“…The joint development of PET and nanotechnology has mutual benefits [ 201 ]. The application of nanozymes in PET is expected to become unprecedented thanks to their unique physical and chemical properties [ 197 ]. Furthermore, PET is an excellent choice for scientists to optimize the pharmacokinetics, intratumoral penetration, tumor bioavailability, and cargo-delivery mechanisms of nanoparticulate agents [ 202 , 203 ].…”

Section: Nanozymes For Molecular Imagingmentioning

confidence: 99%

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Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges

et al. 2023

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New nanotechnologies for imaging molecules are widely being applied to visualize the expression of specific molecules (e.g., ions, biomarkers) for disease diagnosis. Among various nanoplatforms, nanozymes, which exhibit enzyme-like catalytic activities in vivo, have gained tremendously increasing attention in molecular imaging due to their unique properties such as diverse enzyme-mimicking activities, excellent biocompatibility, ease of surface tenability, and low cost. In addition, by integrating different nanoparticles with superparamagnetic, photoacoustic, fluorescence, and photothermal properties, the nanoenzymes are able to increase the imaging sensitivity and accuracy for better understanding the complexity and the biological process of disease. Moreover, these functions encourage the utilization of nanozymes as therapeutic agents to assist in treatment. In this review, we focus on the applications of nanozymes in molecular imaging and discuss the use of peroxidase (POD), oxidase (OXD), catalase (CAT), and superoxide dismutase (SOD) with different imaging modalities. Further, the applications of nanozymes for cancer treatment, bacterial infection, and inflammation image-guided therapy are discussed. Overall, this review aims to provide a complete reference for research in the interdisciplinary fields of nanotechnology and molecular imaging to promote the advancement and clinical translation of novel biomimetic nanozymes.

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Section: Nanozymes For Molecular Imagingmentioning

confidence: 99%

Section: Nanozymes For Molecular Imagingmentioning

confidence: 99%

Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges

et al. 2023

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“…In response to growing demands for reliability and practicality of imaging sensing, organic/inorganic nanohybrids were developed [ 106 ]. Through rational design of the structural parameters regarding composition, morphology and size, a variety of optical properties and biological functions can be achieved [ 107 ]. Recently, Habuchi et al [ 108 ] obtained a series of shortwave infrared-emitting PDs with different sizes by nano-precipitating a saturated solution of conjugated polymers in tetrahydrofuran and changing the mixing volume ratio of the organic to aqueous phase.…”

Section: Ultrasensitive Bioanalysis By Different Ospi Techniquesmentioning

confidence: 99%

Single-Particle Optical Imaging for Ultrasensitive Bioanalysis

Liu

et al. 2022

Biosensors

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The quantitative detection of critical biomolecules and in particular low-abundance biomarkers in biofluids is crucial for early-stage diagnosis and management but remains a challenge largely owing to the insufficient sensitivity of existing ensemble-sensing methods. The single-particle imaging technique has emerged as an important tool to analyze ultralow-abundance biomolecules by engineering and exploiting the distinct physical and chemical property of individual luminescent particles. In this review, we focus and survey the latest advances in single-particle optical imaging (OSPI) for ultrasensitive bioanalysis pertaining to basic biological studies and clinical applications. We first introduce state-of-the-art OSPI techniques, including fluorescence, surface-enhanced Raman scattering, electrochemiluminescence, and dark-field scattering, with emphasis on the contributions of various metal and nonmetal nano-labels to the improvement of the signal-to-noise ratio. During the discussion of individual techniques, we also highlight their applications in spatial–temporal measurement of key biomarkers such as proteins, nucleic acids and extracellular vesicles with single-entity sensitivity. To that end, we discuss the current challenges and prospective trends of single-particle optical-imaging-based bioanalysis.

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“…However, it causes huge distress to cancer patients and risks tumor cell migration [ 16 ]. As a systemic treatment, chemotherapy can kill local or distant metastatic tumors, but serious side effects on the body are inevitable [ 17 , 18 ]. Due to the limitations and side effects of these three traditional therapies, exploring new strategies for cancer therapy is urgently needed [ 19 , 20 , 21 , 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Pillararene-Based Supramolecular Polymers for Cancer Therapy

Yan

Zhou

2023

Molecules

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Supramolecular polymers have attracted considerable interest due to their intriguing features and functions. The dynamic reversibility of noncovalent interactions endows supramolecular polymers with tunable physicochemical properties, self-healing, and externally stimulated responses. Among them, pillararene-based supramolecular polymers show great potential for biomedical applications due to their fascinating host–guest interactions and easy modification. Herein, we summarize the state of the art of pillararene-based supramolecular polymers for cancer therapy and illustrate its developmental trend and future perspective.

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Management of fluorescent organic/inorganic nanohybrids for biomedical applications in the NIR-II region

Abstract: This paper reviews organic and inorganic species as building blocks and various design strategies of NIR-II nanohybrids for intensity-based and lifetime-based bioimaging and biosensing.

Cited by 62 publications

References 111 publications

Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges

Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges

Single-Particle Optical Imaging for Ultrasensitive Bioanalysis

Pillararene-Based Supramolecular Polymers for Cancer Therapy

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