Management of Feline Hyperthyroidism and the Need to Prevent Oxidative Stress: What Can We Learn from Human Research?

Candellone, Alessia; Saettone, Vittorio; Badino, P.; Girolami, Flavia; Radice, Elisabetta; Bergero, Domenico; Odore, R.; Meineri, Giorgia

doi:10.3390/antiox10091496

Cited by 5 publications

(4 citation statements)

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“…Oxidative damage and the generation of reactive oxygen species (ROS) in the mitochondria are increased in hyperthyroidism. 39,42,43 Our research also showed that hypothyroidism leads to elevated indicators of oxidative stress in the body, but capsiates can improve oxidative stress in the PCG and NCG groups.…”

Section: Discussionsupporting

confidence: 54%

“…Additionally, our study shown that although capsiates can reduce oxidative stress in the PCG and NCG groups, hypothyroidism raises oxidative stress markers in the body. Oxidative damage and the generation of reactive oxygen species (ROS) in the mitochondria are increased in hyperthyroidism 39,42,43 . Our research also showed that hypothyroidism leads to elevated indicators of oxidative stress in the body, but capsiates can improve oxidative stress in the PCG and NCG groups.…”

Section: Discussionmentioning

confidence: 60%

“…One important factor in the pathophysiology of hyperthyroidism is oxidative stress. Given that oxidative stress in humans and animals has been linked to both hyperthyroidism and hypothyroidism, 39,40 thyroid hormones are especially important in maintaining the antioxidant equilibrium. As shown in vitro and in animals on a diet high in iodide, oxidative stress can also harm the thyroid gland, especially in situations of iodine overload 41 .…”

Section: Discussionmentioning

confidence: 99%

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Capsiate ameliorates secondary hyperparathyroidism by improving insulin sensitivity and inhibiting angiogenesis

Li,

Zhou,

Wang

et al. 2024

J Cellular Molecular Medi

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Secondary hyperparathyroidism has a significant impact on the overall well‐being of the body. Capsiates, known for their antioxidant and metabolic properties, have emerged as a promising alternative treatment for secondary hyperparathyroidism. This study aims to evaluate the effects and mechanisms of capsiates in the treatment of secondary hyperparathyroidism. To achieve our research objectives, we conducted a study on patients' serum and examined changes in metabolic markers using serum metabolomics. We induced secondary hyperparathyroidism in rat through dietary intervention and divided them into four groups. The first group, referred to as the Parathyroid Hormone (PTH) group, received a low‐calcium and high‐phosphate diet (0.2% calcium, 1.2% phosphorus). The second group served as the control group, receiving a standard phosphate and calcium diet (0.6% calcium, 0.6% phosphorus). The third group, called the capsiates group, consisted of rat from the control group treated with capsiates (intraperitoneal injection of 2 mg/kg capsiates for 2 weeks after 2 weeks of dietary intervention). The fourth group was the capsiates‐treated PTH group. Subsequently, we conducted ribose nucleic acid (RNA) sequencing on parathyroid gland cells and evaluated serum thyroxine levels, oxidative stress, expression of proteins associated with vascular neogenesis, measurement of SOD, GSH and 3‐nitrotyrosine, micro‐CT and histological staining. The serum metabolomic data revealed a significant decrease in capsiate levels in the secondary hyperparathyroidism group. Administration of capsiates to PTH rat resulted in increased calcium levels compared to the PTH group. Additionally, the PTH + Capsiates group showed significantly lower levels of PTH and phosphate compared to the PTH group. The PTH group exhibited a notable increase in the quantity and size of mitochondria compared to the control group. Following capsiates administration to the PTH group, there was a significant reduction in the number of mitochondria and length of microvilli, but an increase in the size of mitochondria compared to the PTH group. Sequencing analysis revealed that vascular endothelial growth factor (VEGF) and Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) play crucial roles in this process. Vascular‐related variables and downstream signalling were significantly elevated in hyperthyroidism and were alleviated with capsaicin treatment. Finally, combining capsiates with the PTH group improved bone mineral density, Tb.N, BV.TV, Cs.Th, Tt.Ar, OPG, Ob.TV and Oc.TV, as well as the mineral apposition rate, but significantly decreased Tb.Sp and Receptor Activator for Nuclear Factor‐κ B Ligand (RANKL) compared to the PTH group. The findings suggest that capsiates can improve secondary hyperparathyroidism and ameliorated osteoporosis outcomes by inhibiting angiogenesis and reducing oxidative stress.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

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Capsiate ameliorates secondary hyperparathyroidism by improving insulin sensitivity and inhibiting angiogenesis

Li,

Zhou,

Wang

et al. 2024

J Cellular Molecular Medi

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“…Авторы показали, что восстановление эутиреоза на фоне приема метимазола у пациентов с гипертиреозом Грейвса на 10-25 % снижает нагрузку системного окислительного стресса. Однако появляются современные данные о том, что фенотип повышенной базальной продукции митохондриальных АФК в эутиреоидную фазу болезни Грейвса может быть связан и с токсическим эффектом длительного лечения метимазолом, усиливающего окислительно-восстановительный дисбаланс [12,13].…”

Section: таблица 3 зимозан-индуцированная хемилюминесценция нейтрофил...unclassified

The level of blood neutrophils primary reactive oxygen species production in Graves’ disease patients undergoing conservative therapy with thiamazole.

Dudina,

Dogadin,

Savchenko

et al. 2024

jour

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Background. Conservative therapy with thiamazole in Graves’ disease helps to reduce the level of oxidative stress by restoring euthyroidism and the total reactive antioxidant potential of plasma. However, until now, in patients with Graves’ disease, the radical-producing ability of neutrophils remains unexplored at the initial stage of free radical conversion at different durations of drug-induced euthyroidism, which seems significant in revealing the mechanisms of disease recurrence. The aim is to study the level of production of primary reactive oxygen species in peripheral blood neutrophils depending on the duration of drug — induced euthyroidism in patients with Graves’ disease. Materials and methods. A single-center, prospective, controlled study was conducted with the participation of patients with laboratory-confirmed Graves’ disease. Subgroups of patients with Graves’ disease were formed depending on the duration of achieved drug-induced euthyroidism with continuous conservative therapy with thiamazole. The level of ROS production in peripheral blood neutrophils was determined by chemiluminescence. The assessment of spontaneous and zymosan-induced chemiluminescence was carried out for 90 minutes on a 36-channel chemiluminescence analyzer BLM-3607 (Medbiotech LLC, Krasnoyarsk). Results. The study included 102 Graves’ disease women with an average age of 47.54 ± 15.47 years. Of these, 75 (73.5 %) with relapse and 27 (26.47 %) with newly diagnosed disease. The total synthesis of (S) primary ROS increased statistically significantly relative to the control values in the examined patients with a duration of the euthyroid state of 5–8 and 9–12 months. It was found that in patients with Graves’ disease with stable drug-induced euthyroidism for 5–8 and 9–12 months, the S index of zymosan-induced lucigenin-dependent chemiluminescence of neutrophils increased statistically significantly, respectively, by 10.7 and 7.4 times relative to the control values. Conclusion. The restoration and maintenance of drug-induced euthyroidism for more than 12 months against the background of conservative thiamazole therapy in patients with Graves’ disease reduces the load of systemic oxidative stress on the immune system. However, the high total production of primary ROS in neutrophils of patients with Graves’ disease in a state of drug-induced euthyroidism with conservative thiamazole therapy may play a significant role in disconnecting the functioning of the NADPH oxidase complex and determine the functional capabilities of neutrophils in case of disease recurrence.

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Elucidating the role of phytocompounds from Brassica oleracea var. italic (Broccoli) on hyperthyroidism: an in-silico approach

Daniel,

Shanmugasundaram,

Chandra Mohan

et al. 2024

In Silico Pharmacol.

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Management of Feline Hyperthyroidism and the Need to Prevent Oxidative Stress: What Can We Learn from Human Research?

Cited by 5 publications

References 61 publications

Capsiate ameliorates secondary hyperparathyroidism by improving insulin sensitivity and inhibiting angiogenesis

Capsiate ameliorates secondary hyperparathyroidism by improving insulin sensitivity and inhibiting angiogenesis

The level of blood neutrophils primary reactive oxygen species production in Graves’ disease patients undergoing conservative therapy with thiamazole.

Elucidating the role of phytocompounds from Brassica oleracea var. italic (Broccoli) on hyperthyroidism: an in-silico approach

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