Management of fatigue in children and adolescents with cancer and in paediatric recipients of haemopoietic stem-cell transplants: a clinical practice guideline

Robinson, Paula D.; Oberoi, Sapna; Tomlinson, Deborah; Duong, Nathan; Davis, Hailey; Cataudella, Danielle; Culos-Reed, S. Nicole; Gibson, Faith; Götte, Miriam; Hinds, Pamela S.; Nijhof, Sanne L.; Torre, Patrick van der; Cabral, Sandra; Dupuis, L. Lee; Sung, Lillian

doi:10.1016/s2352-4642(18)30059-2

Cited by 50 publications

(54 citation statements)

References 34 publications

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“…CBT has been proven to reduce fatigue in adolescents with CFS and in fatigued adults with various chronic diseases 26–28. Other promising interventions include education, exercise or relaxation or are designed to improve one’s self-efficacy or sleep pattern 4 29 30. Whether children and adolescents with fatigue and a chronic disease respond to CBT and other interventions in the same way as adolescents with CFS is of interest for future studies.…”

Section: Discussionmentioning

confidence: 99%

Fatigue in childhood chronic disease

et al. 2019

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Background and objectivesRecently, in adults, the incidence and severity of fatigue was found to exist rather independently from the somatic diagnosis. Since fatigue is distressing when growing up with a chronic disease, we aim to investigate: (1) the prevalence and extent of fatigue among various paediatric chronic diseases and (2) the effect of fatigue on health-related quality of life (HRQoL).Design and settingCross-sectional study in two children’s hospitals.PatientsChildren and adolescents 2–18 years of age with cystic fibrosis, an autoimmune disease or postcancer treatment visiting the outpatient clinic.Outcome measuresFatigue and HRQoL were assessed using the Pediatric Quality of Life Inventory (PedsQL) multidimensional fatigue scale (with lower scores indicating more fatigue) and PedsQL generic core scales, respectively. Linear regression analysis and analysis of covariance were used to compare fatigue scores across disease groups and against two control groups. The effect of fatigue on HRQoL was calculated. Data were adjusted for age, sex and reporting method.Results481 children and adolescents were assessed (60% participation rate, mean age 10.7±4.9, 42% men). Children and adolescents with chronic disease reported more fatigue than the general population (mean difference −6.6, 95% CI −8.9 to –4.3 (range 0–100)), with a prevalence of severe fatigue of 21.2%. Fatigue scores did not differ significantly between disease groups on any fatigue domain. Fatigue was associated with lower HRQoL on all domains.ConclusionsFatigue in childhood chronic disease is a common symptom that presents across disease, age and sex groups. Fatigue affects HRQoL. Our findings underscore the need to systematically assess fatigue. Future studies should determine possible biological and psychosocial treatment targets.

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Section: Discussionmentioning

confidence: 99%

Fatigue in childhood chronic disease

et al. 2019

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“…A prevalent and distressing symptom in children and adolescents with cancer, and in those who have undergone HSCT, is fatigue. A multidisciplinary group of experts in paediatric oncology and fatigue, developed a clinical practice guideline for management of fatigue with the focus on physical activity, relaxation and mindfulness [45].…”

Section: Lifestyle and Risky Health Behaviour Of Cancer Survivorsmentioning

confidence: 99%

Comprehensive assessments and related interventions to enhance the long-term outcomes of child, adolescent and young adult cancer survivors – presentation of the CARE for CAYA-Program study protocol and associated literature review

et al. 2020

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Background: Improved, multimodal treatment strategies have been shown to increase cure rates in cancer patients. Those who survive cancer as a child, adolescent or young adult (CAYA), are at a higher risk for therapy-, or diseaserelated, late or long-term effects. The CARE for CAYA-Program has been developed to comprehensively assess any potential future problems, to offer need-based preventative interventions and thus to improve long-term outcomes in this particularly vulnerable population.

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“…However, in the case where recommendations were based on evidence obtained from adult literature only, the piece was downgraded due to its indirectness ( Figure S2) in agreement with other authors. 19 A 3-day PoE meeting was organized in October 2018, where each subgroup produced the first draft of 15 recommendations and 51 statements. Any common recommendations between groups were unified and a rewording edited by the PoE was discussed in a plenary meeting.…”

Section: Appraisal Of the Evidence And Building Recommendationsmentioning

confidence: 99%