Management of extremity soft tissue sarcomas

Abstract

Soft-tissue sarcomas are a rare and heterogeneous group of tumors. The last few decades have seen rapid strides in surgery with function preserving alternatives for local control in these lesions becoming the norm without compromising on overall disease survival. Good functional and oncological results can be achieved with a combination of excision of the tumor, and where required, suitable adjuvant therapies. These lesions are best managed at specialty centres where the requisite multidisciplinary care can be offered to the patient to optimise results. This overview is intended as a review of current understanding and the multimodality management of these challenging tumors.

Optimization of the Therapeutic Approach to Patients with Sarcoma: Delphi Consensus

“…Finally, the factors influencing the recommendation of perioperative chemotherapy in patients with high-risk extremity or truncal STS are as follows: comorbidities, the presence of which has a very negative impact on the patient's prognosis [19]; histological subtype, since chemosensitivity varies very significantly according to the histology of the tumor [20,21]; and age, as the effectiveness of chemotherapy with or without surgery and/or radiation therapy decreases progressively with age [22]. On this point, the consensus panel identified comorbidities, histological subtype, and age as factors to be evaluated prior to the administration of perioperative chemotherapy in high-risk STS and agreed it is not recommended for the treatment of patients over the age of 75.…”

Multimodality Management of Extremity Soft Tissue Sarcomas—An Indian Perspective

“…Based on our experience we have proposed a suitable algorithm for the management of these lesions (Fig. 4) [30].…”

Clinicopathological pattern of soft tissue sarcoma in a tertiary health institution in North Western Nigeria

“…8 A similar finding was seen in another study where the extremities was the commonest site which was closely followed by the trunk but the retroperitoneum constituted 15%, while the head and neck region was 9%. 18,19 The performance status of cancer patients at presentation affects the prognosis of the disease as patients with poor performance status have worse survival, due to poor tolerance to treatment. 20,21 There is an increasing number of soft tissue sarcoma in our environment, though breast and cervical cancer comprises the greatest proportion of cancer patients, soft tissue sarcoma consists of a significant number of patients seen in Nigeria.…”