Management of Erectile Dysfunction in Patients with Sickle Cell Disease (CME)

Gani, Johan; Radomski, Sidney B.

doi:10.1111/j.1743-6109.2011.02399.x

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…In SCD patients who suffer from recurrent episodes of priapism, erectile dysfunction is not uncommon [185], and the mechanism of priapism in SCD correlates with endothelial dysfunction and NO bioavailability as discussed above [186e189]. We are unaware of any study that has examined the contributing effect of SDB to the erectile dysfunction occurring in SCD, although clearly such relation is plausible.…”

Section: Erectile Dysfunctionmentioning

confidence: 95%

Hemoglobinopathies and sleep – The road less traveled

Gileles‐Hillel

Kheirandish‐Gozal

Gozal

2015

Sleep Medicine Reviews

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Section: Erectile Dysfunctionmentioning

confidence: 95%

Hemoglobinopathies and sleep – The road less traveled

Gileles‐Hillel

Kheirandish‐Gozal

Gozal

2015

Sleep Medicine Reviews

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“…After a major priapism episode that could last from several hours to several days, the normal corporal tissue is replaced with a dense fibrous scar that could render the patient impotent. 6 ED management differs according to patient characteristics, severity of disease, and etiology. It ranges from lifestyle modifications such as diet control, exercise, and weight loss to surgical intervention with a penile prosthesis.…”

Section: Introductionmentioning

confidence: 99%

Case Series of Lipid Accumulation in the Human Corpus Cavernosum

Alwaal

Wang²,

Zaid³

et al. 2015

Medicine

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Erectile dysfunction is a prevalent problem affecting millions of men in the United States and around the world. There have been no reports of the presence of lipids within the human penile corporal bodies, whether in normal or diseased states. We present here a case series of 9 patients who underwent penile corporal tissue biopsy during penile prosthesis insertion with severe intracorporal fibrosis and difficulties during insertion.Oil Red O staining was done to identify lipids; LipidTOX and phalloidin double staining was used to identify lipid location within the corpora, and Masson's trichrome staining was done to assess fibrosis.We identified lipid accumulation in those 9 corporal tissue samples, and further analysis showed the distribution to be 10% intramyocellular lipids and 90% extramyocellular lipids. These 9 specimens contained increased amount of collagen when compared with controls. In addition, we analyzed corporal samples from 10 random erectile dysfunction patients presenting for penile prosthesis insertion and identified no lipid accumulation in those control patients.This is the first report of lipid accumulation in the human corpus cavernosum. Possible mechanisms of lipid accumulation include androgen deficiency and dedifferentiation of corpus smooth muscle cells into other phenotypes; however, the exact mechanism is unknown and further research is needed.

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Sleep in Sickle Cell Disease

Gileles‐Hillel

2021

Pediatric Sleep Medicine

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Management of Erectile Dysfunction in Patients with Sickle Cell Disease (CME)

Cited by 3 publications

References 26 publications

Hemoglobinopathies and sleep – The road less traveled

Hemoglobinopathies and sleep – The road less traveled

Case Series of Lipid Accumulation in the Human Corpus Cavernosum

Sleep in Sickle Cell Disease

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