Management of eosinophilic granuloma localized in the pelvis and extremities

Abstract

Aim: Given the benign biology, and clinical course of eosinophilic granuloma and its higher incidence in pediatric patient group, a successful treatment plan with lower risk for complications is desired. In this study, we aimed to evaluate clinical characteristics, treatment, and outcomes of patients diagnosed with eosinophilic granuloma localized in the pelvis and extremities. Material and Method: Clinical findings, treatment methods, clinical outcomes and treatment failures were evaluated in a total of 19 patients (6 males, 13 females, mean age: 16.5 years, range: 1-37 years) diagnosed with eosinophilic granuloma localized in the pelvis and extremities between 2002 and 2016. Results: The most common mass localization was acetabulum (15%, n = 3). The mean tumor size was 3,7 cm (range: 1-8 cm). All patients presented with pain and had primary tumor. All patients in the study had solitary bone lesion. The mean duration of postoperative follow-up was 46 months (range: 24-95 months). Three patients underwent biopsy alone, and followed-up with adjuvant therapies. In 14 patients, curettage of the lesion was performed at single session during biopsy, and grafting was applied in six of these patients. Two patients underwent excision of the lesion. None of the patients developed recurrence, while a new lesion was detected in the cervical vertebra in one patient after treatment of acetabulum localized lesion. Discussion: The management of eosinophilic granuloma localized in the pelvis and extremities takes place in a wide spectrum varying from observation alone, to lesion curettage, chemotherapy and radiotherapy applications, and prophylactic administration, and treatment tailored for each patient should be planned with a multidisciplinary approach.