Management of endometrial cancer with suspected cervical involvement

Mannel, R. S.; Berman, M.; Walker, JL; Manetta, Alberto; Disaia, P

doi:10.1016/0020-7292(91)90263-5

Cited by 14 publications

(9 citation statements)

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“…Endocervical curettage (ECC) has been commonly used to assess cervical involvement, but the accuracy of this procedure remains controversial [7,10,11,[14][15][16][17][18][19]. The aim of this study is to investigate the value of ECC as a diagnostic procedure in the preoperative staging of patients with adenocarcinoma of the endometrium prior to primary surgery.…”

Section: Introductionmentioning

confidence: 99%

Role of endocervical curettage in the preoperative staging of endometrial carcinoma

Bijen

Bock

Hoor

et al. 2009

Gynecologic Oncology

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a b s t r a c t a r t i c l e i n f oObjective. The presence of cervical involvement is important to establish a rational treatment for endometrial cancer patients. We investigated the value of preoperative endocervical curettage (ECC) in predicting cervical involvement.Methods. Preoperative ECC of 290 patients with clinical stage I epithelial endometrial cancer was compared with histopathology of the uterus.Results. Amongst all ECCs, 245 (84.5%) were negative and 45 (15.5%) were positive for endometrial cancer. In the uterine specimen, cervical involvement was found in 20% (58/290). PPV and NPV of ECC were 86.7% and 92.2%. False negative and false positive ECC occurred in 6.6% and 2.1%. Of all patients with positive ECC, 46.7% had FIGO stage II disease and 46.7% had extra uterine tumor spread (FIGO III, IV).Conclusion. ECC is an acceptable diagnostic tool to predict the presence or absence of cervical involvement in early stage endometrial cancer patients.

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Section: Introductionmentioning

confidence: 99%

Role of endocervical curettage in the preoperative staging of endometrial carcinoma

Bijen

Bock

Hoor

et al. 2009

Gynecologic Oncology

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“…Other large series on surgical‐pathologic staging of endometrial carcinoma also have not provided detail on parametrial spread (2,7,8) . Our pathology findings and the cases reported by others (15,16) suggest that it might be appropriate to incorporate parametrial extension into the staging system for this disease.…”

Section: Discussionmentioning

confidence: 61%

“…Para‐aortic lymphadenectomy was not performed and the method of histologic processing, type of cervical extension (glands vs. stroma), adjuvant treatment, and patterns of recurrence were not detailed. Mannel et al (16) . reported parametrial metastasis in only three of 70 (4%) patients with suspected parametrial involvement preoperatively.…”

Section: Discussionmentioning

confidence: 98%

Parametrial spread in patients with endometrial carcinoma undergoing radical hysterectomy

Tamussino

Reich

Güçer

et al. 2000

Int J Gynecol Cancer

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The objective of this paper is to study parametrial involvement in patients with endometrial carcinoma undergoing radical hysterectomy. We reviewed indications for surgery, pathology findings, and outcome of a series of 24 patients with endometrial carcinoma who underwent radical hysterectomy. The uterus, cervix and parametrial tissue were processed as step-serial sections. Histologically, 16 patients (67%) had carcinoma involving the cervix. Two of these patients (8%) had frank histologic parametrial involvement and four (17%) had disease extending to the transitional zone of the cervix. Parametrial involvement was continuous and seen only in patients with involvement of the cervical stroma. Six patients (25%) had pelvic node metastases. With a median follow-up of 53 months (range 2-140), four patients (17%) developed recurrences (all within 24 months). Twelve patients (50%), including one of the two with parametrial invasion, were free of disease for 5 years or longer. We conclude that direct parametrial extension can occur in locally advanced endometrial cancer. Radical hysterectomy with lymphadenectomy can be an adequate operation for such patients.

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“…3,11 Surgical treatment for patients with cervical involvement ranges from simple to radical hysterectomy. 8,10,14,18 Several authors recommend radical hysterectomy, which carries a better survival rate for patients with cervical involvement than does that for patients who undergo simple hysterectomy. 4,6,8,14 Radical hysterectomy is performed on patients with cervical involvement at many institutions.…”

Section: Objective: To Assess the Relationship Of A Cervical Cytologimentioning

confidence: 99%

“…8,10,14,18 Several authors recommend radical hysterectomy, which carries a better survival rate for patients with cervical involvement than does that for patients who undergo simple hysterectomy. 4,6,8,14 Radical hysterectomy is performed on patients with cervical involvement at many institutions. However, radical hysterectomy carries appreciable morbidity, definitely greater than that of less radical hysterectomy.…”

Section: Objective: To Assess the Relationship Of A Cervical Cytologimentioning

confidence: 99%

Diagnosing Endometrial Carcinoma with Cervical Involvement by Cervical Cytology

et al. 2002

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Management of endometrial cancer with suspected cervical involvement

Cited by 14 publications

References 0 publications

Role of endocervical curettage in the preoperative staging of endometrial carcinoma

Role of endocervical curettage in the preoperative staging of endometrial carcinoma

Parametrial spread in patients with endometrial carcinoma undergoing radical hysterectomy

Diagnosing Endometrial Carcinoma with Cervical Involvement by Cervical Cytology

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