MANAGEMENT OF ENDOCRINE DISEASE: Treatment breaks in long-term management of osteoporosis

Langdahl, Bente

doi:10.1530/eje-18-0282

Cited by 5 publications

(3 citation statements)

References 32 publications

(44 reference statements)

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“…Given that bone remodeling can take months to years before it can occur, long-term anti-osteoporotic therapies are, therefore, desirable. These findings are well-supported by previous reviews which highlighted the significance of long-term follow-up data for improving secondary fragility fractures [ 29 , 35 , 85 , 86 ] and osteoporosis in the elderly [ 87 , 88 ].…”

Section: Discussionsupporting

confidence: 87%

Effectiveness of fracture liaison service in reducing the risk of secondary fragility fractures in adults aged 50 and older: a systematic review and meta-analysis

Danazumi,

Lightbody,

Dermody

2024

Osteoporos Int

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To determine and appraise the certainty of fracture liaison service (FLS) in reducing the risk of secondary fragility fractures in older adults aged ≥ 50 years and to examine the nature of the FLS and the roles of various disciplines involved in the delivery of the FLS. Medline, EMBASE, PubMed, CINAHL, SCOPUS, and The Cochrane Library were searched from January 1st, 2010, to May 31st, 2022. Two reviewers independently extracted data. The risk of bias was evaluated using the Newcastle–Ottawa Scale for cohort studies and the PEDro scale for randomized trials, while the GRADE approach established the certainty of the evidence. Thirty-seven studies were identified of which 34 (91.9%) were rated as having a low risk of bias and 22 (59.5%) were meta-analyzed. Clinically important low certainty evidence at 1 year (RR 0.26, CI 0.13 to 0.52, 6 pooled studies) and moderate certainty evidence at ≥ 2 years (RR 0.68, CI 0.55 to 0.83, 13 pooled studies) indicate that the risk of secondary fragility fracture was lower in the FLS intervention compared to the non-FLS intervention. Sensitivity analyses with no observed heterogeneity confirmed these findings. This review found clinically important moderate certainty evidence showing that the risk of secondary fragility fracture was lower in the FLS intervention at ≥ 2 years. More high-quality studies in this field could improve the certainty of the evidence. Review registration: PROSPERO―CRD42021266408. Supplementary Information The online version contains supplementary material available at 10.1007/s00198-024-07052-1.

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Section: Discussionsupporting

confidence: 87%

Effectiveness of fracture liaison service in reducing the risk of secondary fragility fractures in adults aged 50 and older: a systematic review and meta-analysis

Danazumi,

Lightbody,

Dermody

2024

Osteoporos Int

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“…Given the length of most treatments, adherence to medication is a challenge when treating OP patients [67]. Interventions that are crucial for treatment adherence include education, improved communication, cultural respect, improvement in dosing programs, SE consideration, and appointment reminders [68].…”

Section: Treatment Durationmentioning

confidence: 99%

Updated approach for the management of osteoporosis in Turkey: a consensus report

Kirazlı

Çalış

et al. 2020

Arch Osteoporos

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As a result of the current demographics, increased projections of osteoporosis (OP) and prevalence of the disease in Turkey, a panel of multidisciplinary experts developed a thorough review to assist clinicians in identifying OP and associated fracture risk patients, diagnosing the disease with the appropriate available diagnostic methods, classifying the disease, and initiating appropriate treatment. The panel expects to increase the awareness of this prevalent disease, decrease consequences of OP with corresponding cost savings and, ultimately, decrease the overall burden of OP and related fractures in Turkey. Background OP is not officially accepted as a chronic disease in Turkey despite the high prevalence and predicted increase in the following years. However, there are areas where the country is performing well, such as having a country-specific fracture risk assessment model, DXA access, and the uptake of FRAX. Additional efforts are required to decrease the existing treatment gap estimating 75-90% of patients do not receive pharmacological intervention for secondary prevention, and the diagnosis rate is around 25%. Methods A selected panel of Turkish experts in fields related to osteoporosis was provided with a series of relevant questions to address prior to the multi-day conference. Within this conference, each narrative was discussed and edited by the entire group, through numerous drafts and rounds of discussion until a consensus was achieved. Represented in the panel were a number of societies including The Turkish Osteoporosis Society, The Society of Endocrinology and Metabolism of Turkey (SEMT), and The Turkish Society of Physical Medicine and Rehabilitation. Results Standardized general guidelines to identify OP and related fractures and at-risk population in Turkey, which will enable clinicians to accurately and effectively diagnose the disease, treat the appropriate patients with available pharmacological and non-pharmacological treatments and decrease the burden of the disease. Conclusions This manuscript provides a review of the current state of OP and related fractures in Turkey. Moreover, this manuscript reviews current international guidelines and national studies and proposes a number of helpful country-specific classifications that can be used by healthcare providers caring for the at-risk population. Additionally, the panel proposes practical recommendations that should be implemented nationally in order to decrease the burden of OP and related fractures and effectively preventing the burden in future generations.

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“…Poor compliance and other concomitant ageing disorders of the patients make the assessment of long-term efficacy and adverse effects very difficult. This could possibly explain why there are currently limited studies to examine these factors for long periods of treatment and follow-up (9,12) .…”

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confidence: 99%

The effect of table olive wastewater extract administration on the adult ovariectomised rat model of osteoporosis

et al. 2021

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Recent efforts for alternative non-pharmaceutical treatments for postmenopausal osteoporosis are focused on nutritional measures. The aim of this study was to investigate the effect of table olive wastewater extract (OE) administration on bone mineral density (BMD) and biomechanical strength in ovariectomized rats. Thirty mature 9-month-old female Wistar rats were separated into 3 groups of ten; Control, Ovariectomized (OVX) and OVX+OE. BMD was measured before ovariectomy, 3 and 6 months afterwards. At the end of the study, blood, both femurs and tibias, internal organs and abdominal fat were collected. After three months, the percentage changes from baseline of the total and proximal tibial BMD of the OVX+OE group were both higher compared to the OVX group (p<0.005). Similar results were found after six months, when the percentage changes from baseline of the total and proximal tibial BMD of the OVX+OE group were both higher compared to the OVX group (p<0.005). Biomechanical testing of the femurs did not reveal any statistically significant difference between the groups. Body weights throughout the study, organs’ and abdominal fat ratios to final body weight, blood results (alanine aminotransferase; ALT, Gamma-glutamyltransferase; γ-GT, total cholesterol, high-density lipoprotein; HDL-cholesterol, low-density lipoprotein; LDL-cholesterol, calcium, phosphorus) were within normal limits and did not show any significant difference between the treated and untreated groups. As a conclusion, the administration of table olive wastewater extract for 6 months protected tibial BMD loss in comparison to the untreated OVX group without causing adverse effects.

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MANAGEMENT OF ENDOCRINE DISEASE: Treatment breaks in long-term management of osteoporosis

Cited by 5 publications

References 32 publications

Effectiveness of fracture liaison service in reducing the risk of secondary fragility fractures in adults aged 50 and older: a systematic review and meta-analysis

Effectiveness of fracture liaison service in reducing the risk of secondary fragility fractures in adults aged 50 and older: a systematic review and meta-analysis

Updated approach for the management of osteoporosis in Turkey: a consensus report

The effect of table olive wastewater extract administration on the adult ovariectomised rat model of osteoporosis

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