The laryngeal cancer is the second most frequent neoplasm of the upper aerodigestive tract. In these patients, the incidence of difficult airway is very high, and sometimes the anatomy can be modified because of the previous treatments like radiotherapy, making difficult intubation and difficult mask ventilation. To prevent an emergency, it is a priority to make an approach plan, appropriate preoperative assessment, have the necessary tools, and work together with the surgical team.