Management of Eclampsia at AKTH: Before and After Magnesium Sulphate

A systematic review of maternal and infant outcomes following magnesium sulfate for pre-eclampsia/eclampsia in real-world use

“…Similarly, in the other studies [22][23][24][25], women with eclampsia who were treated with magnesium sulfate had a lower risk of death compared with women treated with other anticonvulsants.…”

“…The 6 studies that were included were all cohort studies [4,[22][23][24][25][26]. They included 536 women with eclampsia treated with magnesium sulfate and 698 who were treated with another anticonvulsant [22][23][24][25] (Table 1).…”

“…They included 536 women with eclampsia treated with magnesium sulfate and 698 who were treated with another anticonvulsant [22][23][24][25] (Table 1). In addition, 2 population-based studies from the UK (analyzed as a before-and-after pair) identified 383 (of 774 436) women with eclampsia when no prophylactic anticonvulsant for preeclampsia was common practice [4] and 214 women with eclampsia after magnesium sulfate had become standard care for women with severe pre-eclampsia [26].…”

“…In the other studies, perinatal mortality among women with eclampsia treated with magnesium sulfate compared with women treated with other anticonvulsants was: 30% versus 37% [25]; and 39% versus 56% [23].…”

“…Tukur and Muhammad [25] reported on magnesium toxicity, with a total of 8 cases in 93 women-7 due to renal toxicity and 1 due to respiratory toxicity-although details on treatment or outcome were not included in the manuscript.…”