Management of dyspnea in advanced lung cancer: recent data and emerging concepts

Xue, Dong; Abernethy, Amy P.

doi:10.1097/spc.0b013e328339920d

Cited by 14 publications

(7 citation statements)

References 47 publications

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“…A recent review concluded that few definitive data are available evaluating the effectiveness of dyspnea interventions, and that randomized controlled trials are needed. 59 Other reviews have determined that data are sufficient to make treatment recommendations. 57,60 Pharmacologic interventions include opioids or benzodiazapines.…”

Section: Palliative Care Interventionsmentioning

confidence: 99%

Palliative Care

Lévy¹,

Adolph²,

Back³

et al. 2012

J Natl Compr Canc Netw

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These guidelines were developed and updated by an interdisciplinary group of experts based on clinical experience and available scientific evidence. The goal of these guidelines is to help patients with cancer experience the best quality of life possible throughout the illness trajectory by providing guidance for the primary oncology team for symptom screening, assessment, palliative care interventions, reassessment, and afterdeath care. Palliative care should be initiated by the primary oncology team and augmented by collaboration with an interdisciplinary team of palliative care experts.

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Section: Palliative Care Interventionsmentioning

confidence: 99%

Palliative Care

Lévy¹,

Adolph²,

Back³

et al. 2012

J Natl Compr Canc Netw

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“…(2010), Synthesis of systemic reviews -breathlessness in respiratory illness[8]; B, Roberston-Malt (2010), Synthesis of systematic reviews -asthma[9]; C, Simon et al(2010), Systemic review -benzodiazepines in malignant and nonmalignant disease [11 ]; D, Hunt et al, Systemic review -heliox during exercise in COPD [10]; E, Thomas et al (2010), Systemic review -COPD [12]; F, Alifano et al (2010), Narrative review -COPD [13]; G, Davidson and Currow (2010), Narrative review -refractory dyspnoea multiple diseases [14 ]; H, Gibson et al (2010), Narrative review -acupuncture for respiratory disorders [15]; I, Johnson and Oxenbury (2010), Narrative review -chronic heart failure [16 ]; J, McMurray (2010), Narrative review -systolic heart failure [17]; K, Sajkov et al (2010), Narrative review -pulmonary hypertension [18 ]; L, Shannon (2010), Narrative review -lung cancer [19]; M, Riario-Sforza et al (2010), Narrative review -COPD [20]; N, Ryerson et al (2010), Narrative reviewinterstitial lung disease [21 ]; O. Mahler et al (2010), Consensus statement -advanced lung or heart disease[23 ]; P, Xue and Abernethy (2010), Narrative review -advanced lung cancer[22].…”

mentioning

confidence: 99%

Applicability and generalizability of palliative interventions for dyspnoea: one size fits all, some or none?

Williams¹

2011

Current Opinion in Supportive &Amp; Palliative Care

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Multiple interventions exist for palliation of dyspnoea in different contexts. The majority of studies assessed emotional and behavioural consequences of dyspnoea rather than dyspnoea sensation (intensity, sensory quality, unpleasantness). As a more detailed understanding of the mechanisms leading to perceptions of dyspnoea evolve, a 'back to basics' strategy for clinical assessment might provide a means of determining which interventions can be generalized or are best suited to various forms of dyspnoea.

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“…Dyspnea is a distressing symptom that is highly prevalent among patients with LC 4 - 8 ; mitigating this symptom is a high priority and a clear unmet need. In this pilot study, we demonstrated successful recruitment and retention to a study of acupuncture for dyspnea in LC.…”

Section: Discussionmentioning

confidence: 99%

“… 2 , 3 Dyspnea is present in up to 87% of patients with LC and has a profound impact on quality of life and survival. 4 - 8 The existing literature is sparse on interventions to improve dyspnea for patients with LC. 9 Physicians also appear to treat the dyspnea associated with LC less aggressively than they do dyspnea associated with chronic lung disease.…”

Section: Introductionmentioning

confidence: 99%

Acupuncture for Dyspnea in Lung Cancer

et al. 2016

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Purpose. Dyspnea is a common and distressing symptom for patients with lung cancer (LC) because of disease burden, therapy toxicity, and comorbid illnesses. Acupuncture is a centuries-old therapy with biological plausibility for relief of dyspnea in this setting. This pilot study aimed to evaluate the feasibility and preliminary effectiveness of acupuncture for dyspnea among patients with LC. Methods. Eligible patients had a diagnosis of LC and clinically significant dyspnea without a clear organic cause. The treatment consisted of 10 weekly acupuncture sessions, with a follow-up visit 4 weeks after therapy. The primary outcome was dyspnea severity as measured using a validated Numerical Rating Scale (NRS) of 0 to 10 (10 being “most severe shortness of breath imaginable”). Results. We enrolled 12 patients in the study. The median age was 64.5 years; 66.7% of the patients were female, and 66.7% were Caucasians. Among those enrolled, 10 (83.3%) were able to complete all 10 acupuncture sessions. Acupuncture was well tolerated; adverse events were mild and self-limited. Mean (SD) dyspnea scores on the NRS improved from 6.3 (1.7) at baseline to 3.6 (1.9; P = .003) at the end of treatment and 3.2 (2.3; P = .008) at follow-up. Fatigue and quality of life also improved significantly with acupuncture (P < .05). Conclusion. Among patients with LC, acupuncture was well tolerated and exhibited promising preliminary beneficial effects in the treatment of dyspnea, fatigue, and quality of life. Performing a trial in this population appears feasible.

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Management of dyspnea in advanced lung cancer: recent data and emerging concepts

Abstract: This study reviews several interesting advances in the area of dyspnea with respect to symptom assessment and management.

Cited by 14 publications

References 47 publications

Palliative Care

Palliative Care

Applicability and generalizability of palliative interventions for dyspnoea: one size fits all, some or none?

Acupuncture for Dyspnea in Lung Cancer

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