Management of dementia with a cerebrovascular component

Bocti, Christian; Black, Sandra E.; Frank, Chris

doi:10.1016/j.jalz.2007.07.009

Cited by 24 publications

(26 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Further research will be needed to assess the prognosis and progression of aMCI with a heavy vascular burden. Finally, those results further emphasize the importance of treating vascular risk factors and diseases in MCI and AD when possible [43][44][45] . They suggest that by controlling for vascular risk factors and diseases, it might be possible to prevent or attenuate the executive deficit among aMCI.…”

Section: Discussionmentioning

confidence: 81%

Impact of Vascular Risk Factors and Diseases on Cognition in Persons with Mild Cognitive Impairment

Villeneuve

Belleville

Massoud

et al. 2009

Dement Geriatr Cogn Disord

Self Cite

View full text Add to dashboard Cite

Background/Aim: To investigate the impact of vascular burden (assessed by the number of vascular risk factors and diseases) on the cognition of persons with amnestic mild cognitive impairment (aMCI). Methods: This study included 145 participants; 68 meeting criteria for amnesic single-domain or multiple-domain MCI and 77 matched controls. Four cognitive domains were assessed: executive functions, processing speed, episodic memory and general cognitive functioning. Results: A larger vascular burden among aMCI is correlated with lower performance in the executive domain. In addition, persons with aMCI with high vascular burden were more frequently of the multiple domain subtype, whereas persons with no vascular burden were more frequently of the single domain subtype. Conclusion: Our findings suggest that the combined effect of multiple vascular risk factors and diseases increases the amount of executive impairment in persons with aMCI. Vascular burden may play an important role in the heterogeneity of aMCI by impairing cognitive functions other than memory.

show abstract

Section: Discussionmentioning

confidence: 81%

Impact of Vascular Risk Factors and Diseases on Cognition in Persons with Mild Cognitive Impairment

Villeneuve

Belleville

Massoud

et al. 2009

Dement Geriatr Cogn Disord

Self Cite

View full text Add to dashboard Cite

show abstract

“…The MoCA was designed to detect mild cognitive impairment [17] and may be appropriate for vascular cognitive impairment screening given its sampling of executive functions, visuospatial abilities, language, memory and abstract reasoning [8,18]. The Mini-Mental State Examination (MMSE) remains widely used in the medical community, despite poor sensitivity in patients with cerebrovascular disease, especially with milder cognitive deficits [19].…”

Section: Introductionmentioning

confidence: 99%

Vascular Cognitive Impairment: Most Useful Subtests of the Montreal Cognitive Assessment in Minor Stroke and Transient Ischemic Attack

Bocti

Legault

Leblanc

et al. 2013

Dement Geriatr Cogn Disord

Self Cite

View full text Add to dashboard Cite

Background/Aims: Cognitive impairment is frequent in cerebrovascular disease but often remains undetected. The Montreal Cognitive Assessment (MoCA) has been proposed in this context. Our aim was to evaluate the MoCA and its subtests in cerebrovascular disease. Methods: We assessed 386 consecutive patients with minor stroke (National Institutes of Health Stroke Score <4) or transient ischemic attack at 3 months. The MoCA and the modified Rankin Scale (mRS) were administered. Computed tomography (CT) scans were assessed for stroke and white matter changes. An unfavorable functional outcome was defined as mRS >1. Results: The prevalence of cognitive impairment (cutoff of 26) was 55% using the MoCA and 13% using the MMSE. In a multivariate analysis, MoCA <26 was associated with the outcome (OR 3.00, CI 1.78-5.03), as were remote lacunar stroke on CT and white matter changes of at least moderate severity. Five subtests (5-word recall, word list generation, trail-making, abstract reasoning and cube copy) formed an optimal short MoCA with 6/10 or less showing a sensitivity of 91% and a specificity of 83%. Conclusion: This study extends the utility of the MoCA to milder forms of cerebrovascular disease. The MoCA is associated with the 3-month functional outcome. Five subtests may constitute an optimal brief tool in vascular cognitive impairment.

show abstract

“…Briefl y, the consensus conference adhered to the methods of the AGREE collaboration [9]. For this update, the working group reviewed the previous pharmacological recommen dations from each working group of CCCDTD3 [10][11][12][13][14]. A literature search was conducted with PubMed and Embase, examining articles published from January 2006 until April 2012.…”

Section: Methodsmentioning

confidence: 99%

Pharmacological recommendations for the symptomatic treatment of dementia: the Canadian Consensus Conference on the Diagnosis and Treatment of Dementia 2012

Herrmann

Lanctôt

Hogan

2013

Alzheimers Res Ther

View full text Add to dashboard Cite

Management of dementia with a cerebrovascular component

Abstract: A more pro-active stance towards cognitive decline of vascular etiology is warranted, with some evidence supporting both prevention and symptomatic therapy.

Cited by 24 publications

References 46 publications

Impact of Vascular Risk Factors and Diseases on Cognition in Persons with Mild Cognitive Impairment

Impact of Vascular Risk Factors and Diseases on Cognition in Persons with Mild Cognitive Impairment

Vascular Cognitive Impairment: Most Useful Subtests of the Montreal Cognitive Assessment in Minor Stroke and Transient Ischemic Attack

Pharmacological recommendations for the symptomatic treatment of dementia: the Canadian Consensus Conference on the Diagnosis and Treatment of Dementia 2012

Contact Info

Product

Resources

About