Management of Cystic Fibrosis during COVID-19: Patient Reported Outcomes based remote follow-up among CF patients in Denmark – A feasibility study

Rodkjær, Lotte Ørneborg; Jeppesen, Majbritt; Schougaard, Liv Marit Valen

doi:10.1016/j.jcf.2021.10.010

Cited by 8 publications

(5 citation statements)

References 17 publications

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“…Although the COVID-19 pandemic was a challenging time for people with CF, it also resulted in some positive effects and conclusions. One of them was raising awareness about the necessity of mental-health-monitoring and promotion amongst not only the patients but also their caregivers and therapeutic teams [ 35 , 49 ]. Although studies show that, during lockdowns, the physical activity of patients was often disturbed and less frequent, it also caused more consistency in their daily respiratory therapies and more adherence to general therapies [ 36 , 40 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

Mental Health of Cystic Fibrosis Patients and the COVID-19 Pandemic in Poland: A Single-Center Comparative Study

Humaj-Grysztar

Rachel

Śmiech-Michalec

et al. 2022

IJERPH

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Research shows that people with cystic fibrosis are more prone to suffer from psychological problems than healthy people; thus, the outbreak of the COVID-19 pandemic in Poland could have had an impact on their mental health. To assess this impact, we examined the mental health of patients before and during the pandemic. Survey participants were asked to fill in questionnaires that consisted of Beck Depression Inventory (BDI), 12-Item General Health Questionnaire (GHQ-12) and Cystic Fibrosis Questionnaire-Revised (CFQ-R; for the purpose of the study, an emotional functioning domain was used) during their hospital visits. A total of 81 patients took part in the study: 39 before the COVID-19 pandemic (BP) and 42 during the COVID-19 pandemic (DP). Patients’ medians were lower for the BDI, GHQ-12 and higher for the emotional domain of CFQ-R during the pandemic (3, 6, 75 vs. 4, 10, 73.33). Fewer patients felt that their mental health had deteriorated during the pandemic (Δχ2 = 7.723; p = 0.005), and GHQ-12 scores were lower in the DP group (Z = −3.044; p = 0.002). No significant differences were found between groups in terms of experiencing depressive symptoms (Δχ2 = 1.036; p = 0.309). It was found that patients with cystic fibrosis from our study group not only maintained but also improved their mental health state during the COVID-19 pandemic.

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Section: Discussionmentioning

confidence: 99%

Mental Health of Cystic Fibrosis Patients and the COVID-19 Pandemic in Poland: A Single-Center Comparative Study

Humaj-Grysztar

Rachel

Śmiech-Michalec

et al. 2022

IJERPH

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“…Initial results were disappointing, as a high proportion of patients reverted to regular physical visits due to technical barriers. Nevertheless, newer experiences from the Aarhus CF Center were more positive [36]. The area remains a priority, as it could save time for patients and reduce the risk of cross‐infection.…”

Section: Principles Of Care In the Danish Cystic Fibrosis Cohortmentioning

confidence: 99%

Close monitoring and early intervention: management principles for cystic fibrosis in Denmark

Qvist,

Nielsen,

Olesen

et al. 2024

APMIS

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Cystic fibrosis (CF) care in Denmark has been characterized by close monitoring and pre‐emptive treatment of lung disease and other CF‐related complications. Continuous evaluation through data collection and commitment to clinical research has incrementally improved outcomes. This approach has been in line with best practices set forth by European Standards of Care but has also gone beyond Society standards particularly pertaining to early treatment with high‐dose combination antimicrobial therapy. Despite a high prevalence of severe CF variants, lung function has been among the best in Europe. In this review, the Danish approach to management of CF prior to the introduction of new CF modulator treatment is explained and benchmarked. Downsides to the Danish approach are discussed and include increased burden of treatment, risk of antimicrobial resistance, side‐effects and costs.

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“…Most of these studies have demonstrated that the majority of people with CF recover fully and maintain their lung function despite COVID-19 infection although some individuals experience more serious disease. [60][61][62][63][64][65][66][67][68] The longer term effects of COVID-19 in people with CF remain unknown. Studies of COVID-19 in CF have consistently identified previous solid organ transplantation as a key risk factor for adverse outcomes including ICU admission and death.…”

Section: Coronavirus Disease 2019 In Cystic Fibrosismentioning

confidence: 99%

“…To supplement remote consultations, digital strategies in the form of electronic monitoring of nebulizer adherence, home spirometers, and continuous blood glucose monitoring systems were utilized by many centers. Reports of patient and carer satisfaction with this widespread shift to telehealth have been mixed; some authors have described a mainly successful implementation, 60 68 74 while others have reported a more balanced effect. 71 Additional impacts of the COVID-19 pandemic relevant to CF care have included limitation of lung transplantation availability and in many cases a delay in transition to adult CF services.…”

Section: Coronavirus Disease 2019 In Cystic Fibrosismentioning

confidence: 99%

Respiratory Viruses and Cystic Fibrosis

Brackenborough

Ellis

Flight

2022

Semin Respir Crit Care Med

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The threat of respiratory virus infection to human health and well-being has been clearly highlighted by the coronavirus disease 2019 (COVID-19) pandemic. For people with cystic fibrosis (CF), the clinical significance of viral infections long predated the emergence of severe acute respiratory syndrome coronavirus 2. This article reviews the epidemiology, diagnosis, and treatment of respiratory virus infection in the context of CF as well as the current understanding of interactions between viruses and other microorganisms in the CF lung. The incidence of respiratory virus infection in CF varies by age with young children typically experiencing more frequent episodes than adolescents and adults. At all ages, respiratory viruses are very common in CF and are associated with pulmonary exacerbations. Respiratory viruses are identified at up to 69% of exacerbations, while viruses are also frequently detected during clinical stability. The full impact of COVID-19 in CF is yet to be established. Early studies found that rates of COVID-19 were lower in CF cohorts than in the general population. The reasons for this are unclear but may be related to the effects of shielding, infection control practices, maintenance CF therapies, or the inflammatory milieu in the CF lung. Observational studies have consistently identified that prior solid organ transplantation is a key risk factor for poor outcomes from COVID-19 in CF. Several key priorities for future research are highlighted. First, the impact of highly effective CFTR modulator therapy on the epidemiology and pathophysiology of viral infections in CF requires investigation. Second, the impact of respiratory viruses on the development and dynamics of the CF lung microbiota is poorly understood and viral infection may have important interactions with bacteria and fungi in the airway. Finally, bacteriophages represent a key focus of future investigation both for their role in transmission of antimicrobial resistance and as a promising treatment modality for multiresistant pathogens.

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Management of Cystic Fibrosis during COVID-19: Patient Reported Outcomes based remote follow-up among CF patients in Denmark – A feasibility study

Cited by 8 publications

References 17 publications

Mental Health of Cystic Fibrosis Patients and the COVID-19 Pandemic in Poland: A Single-Center Comparative Study

Mental Health of Cystic Fibrosis Patients and the COVID-19 Pandemic in Poland: A Single-Center Comparative Study

Close monitoring and early intervention: management principles for cystic fibrosis in Denmark

Respiratory Viruses and Cystic Fibrosis

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