Management of cystic diseases of the pancreas

Şentürk, Hakan

doi:10.5152/tjg.2014.0001

Cited by 2 publications

(1 citation statement)

References 67 publications

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“…Given the malignant potential of MCNs (10%–39%) and IPMNs (36%–100%), routine monitoring is mandatory [ 3 ]. However, there is no single criterion or follow-up model for mucinous PCLs [ 4 ]. We aimed to analyze the role of cyst fluid carcinoembryonic antigen (CEA) level in differentiating MCNs from IPMNs as well as low-risk (LR)- versus high-risk (HR)-IPMNs.…”

Section: Introductionmentioning

confidence: 99%

Cyst Fluid Carcinoembryonic Antigen Level Difference between Mucinous Cystic Neoplasms and Intraductal Papillary Mucinous Neoplasms

Köker¹,

Ünver

Malya

et al. 2021

Clin Endosc

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Background/Aims The role of cyst fluid carcinoembryonic antigen (CEA) level in differentiating mucinous pancreatic cystic lesions (PCLs) is controversial. We investigated the role of cyst fluid CEA in differentiating low-risk (LR)-intraductal papillary mucinous neoplasms (IPMNs) from high-risk (HR)-IPMNs and LR-mucinous cystic neoplasms (MCNs). Methods This was a retrospective study of 466 patients with PCLs who underwent endoscopic ultrasound-guided fine-needleaspiration over a 7-year period. On histology, low-grade dysplasia and intermediate-grade dysplasia were considered LR, whereas high-grade dysplasia and invasive carcinoma were considered HR. Results Data on cyst fluid CEA levels were available for 50/102 mucinous PCLs with definitive diagnoses. The median CEA (range) levels were significantly higher in HR cysts than in LR cysts (2,624 [0.5–266,510] ng/mL vs. 100 [16.8–53,445]ng/mL, p =0.0012). The area under the receiver operating characteristic curve (AUROC) was 0.930 (95% confidence interval [CI], 0.5–0.8; p <0.001) for differentiating LR-IPMNs from LR-MCNs. The AUROC was 0.921 (95% CI, 0.823–1.000; p <0.001) for differentiating LR-IPMNs from HR-IPMNs. Both had a CEA cutoff level of >100ng/mL, with a negative predictive value (NPV) of 100%. Conclusions Cyst fluid CEA levels significantly vary between LR-IPMNs, LR-MCNs, and HR-IPMNs. A CEA cutoff level of >100ng/mL had a 100% NPV in differentiating LR-IPMNs from LR-MCNs and HR-IPMNs.

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Section: Introductionmentioning

confidence: 99%